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- W1965575645 abstract "In situ end labeling combined with YOYO staining was used to mark apoptotic DNA fragmentation and chromatin condensation respectively in human postmortem brain sections. Increased numbers of apoptotic neuronal nuclei were identified in the Parkinson's disease (PD) nigra compared with age-matched controls. Caspase 3 and Bax showed increased immunoreactivity in melanized neurons of the PD nigra compared with controls. Importantly, GAPDH nuclear accumulation was also observed in the PD nigra, suggesting apoptotic rather than necrotic cell death. Interestingly, both Lewy bodies and the intranuclear Marinesco's bodies were GAPDH immunoreactive in the PD brain." @default.
- W1965575645 created "2016-06-24" @default.
- W1965575645 creator A5059134028 @default.
- W1965575645 date "2000-11-01" @default.
- W1965575645 modified "2023-10-17" @default.
- W1965575645 title "Increased Caspase 3 and Bax Immunoreactivity Accompany Nuclear GAPDH Translocation and Neuronal Apoptosis in Parkinson's Disease" @default.
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- W1965575645 doi "https://doi.org/10.1006/exnr.2000.7489" @default.
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