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- W1965576109 abstract "Nitric oxide (NO) has been suggested to have a neurotoxic role in the brain, while transforming growth factor-β (TGF-β) has been considered to be a suppressor of inflammatory cytokine release. The amounts of these modulators that are released by rat brain cultures were measured for tissue obtained from rats of different maturational age groups: weanling (3 weeks), young (3 months), and middle-aged (12 months) rats. Basal levels of brain-derived NO increased with age. This was attributed to brain microglial-derived NO. Culturing of the brain tissue with LPS or PGE2 further increased the amount of NO elaborated from brain cultures of 3-week-old and 3-month-old rats to a level that was similar to the high amounts detected in unstimulated brain cultures from 12-month-old rats. Stimulation of brain cultures from 12-month-old rats did not further enhance NO levels. In contrast to the maturation-associated increase in NO production, levels of brain-derived bioactive TGF-β declined with age. LPS and PGE2 increased the amount of bioactive TGF-β released by brain cultures of each rat age group, but there nevertheless remained an age-related reduction in active TGF-β levels. These results suggest a possible developmental association between an enhancement of brain-derived NO and a concomitant decline in brain TGF-β." @default.
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- W1965576109 date "1995-04-01" @default.
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- W1965576109 title "Production of nitric oxide and transforming growth factor-β in developing and adult rat brain" @default.
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- W1965576109 doi "https://doi.org/10.1016/0047-6374(94)01545-w" @default.
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