FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965576979> ?p ?o ?g. }

• W1965576979 endingPage "3608" @default.
• W1965576979 startingPage "3602" @default.
• W1965576979 abstract "Abstract Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T-cell lymphoma/leukemia (ATL). The HTLV-1 envelope gene exhibits limited variability when examined from infected individuals, but has not been tested using infectious clones of the virus in animal models. In vitro assays indicate that HTLV-1 envelope (Env) Ser75Ile, Asn95Asp, and Asn195Asp surface unit (SU) mutants are able to replicate in and immortalize lymphocytes. Herein, we examined the effects of these Env mutants in rabbits inoculated with HTLV-1 immortalized ACH.75, ACH.95, or ACH.195 cell lines (expressing full-length molecular clones with the SU mutations) or the ACH.1 cell line (expressing wild-type SU). All rabbits became infected, and the fidelity of the mutations was maintained throughout the 8-week study. However, SU point mutations resulted in decreased antibody responses to viral group-associated antigen (Gag) and Env antigens. ACH.195 rabbits had a selective decreased antibody response to SU, and one ACH.195 rabbit had an antibody response to both HTLV-1 and HTLV-2 SUs. Some mutant inoculation groups had altered proviral loads. However, peripheral-blood mononuclear cell (PBMC) proviral loads did not correlate with antibody responses. Our data are the first to demonstrate that mutations in critical determinants of HTLV-1 Env SU altered antibody responses and proviral loads, but do not prevent viral replication in vivo." @default.
• W1965576979 created "2016-06-24" @default.
• W1965576979 creator A5040296760 @default.
• W1965576979 creator A5051642123 @default.
• W1965576979 creator A5061423789 @default.
• W1965576979 creator A5068289010 @default.
• W1965576979 creator A5069156105 @default.
• W1965576979 creator A5078184468 @default.
• W1965576979 creator A5084498101 @default.
• W1965576979 date "2005-11-15" @default.
• W1965576979 modified "2023-10-16" @default.
• W1965576979 title "In vivo analysis of replication and immunogenicity of proviral clones of human T-lymphotropic virus type 1 with selective envelope surface-unit mutations" @default.
• W1965576979 cites W1500263965 @default.
• W1965576979 cites W1508993472 @default.
• W1965576979 cites W1585892244 @default.
• W1965576979 cites W1589591642 @default.
• W1965576979 cites W1591641721 @default.
• W1965576979 cites W1797010585 @default.
• W1965576979 cites W1829413738 @default.
• W1965576979 cites W1886710724 @default.
• W1965576979 cites W1938054245 @default.
• W1965576979 cites W1977325814 @default.
• W1965576979 cites W1981906666 @default.
• W1965576979 cites W1991338345 @default.
• W1965576979 cites W1993961716 @default.
• W1965576979 cites W1998900698 @default.
• W1965576979 cites W2016607742 @default.
• W1965576979 cites W2025200528 @default.
• W1965576979 cites W2044693210 @default.
• W1965576979 cites W2045651327 @default.
• W1965576979 cites W2057732582 @default.
• W1965576979 cites W2062418578 @default.
• W1965576979 cites W2068606955 @default.
• W1965576979 cites W2074996399 @default.
• W1965576979 cites W2079964631 @default.
• W1965576979 cites W2094507249 @default.
• W1965576979 cites W2103519631 @default.
• W1965576979 cites W2103798850 @default.
• W1965576979 cites W2117109344 @default.
• W1965576979 cites W2119678477 @default.
• W1965576979 cites W2120998555 @default.
• W1965576979 cites W2121839969 @default.
• W1965576979 cites W2126838772 @default.
• W1965576979 cites W2141928160 @default.
• W1965576979 cites W2144435232 @default.
• W1965576979 cites W2148304159 @default.
• W1965576979 cites W2152458930 @default.
• W1965576979 cites W2153153270 @default.
• W1965576979 cites W2165343463 @default.
• W1965576979 cites W2273376655 @default.
• W1965576979 cites W2279401375 @default.
• W1965576979 cites W29921343 @default.
• W1965576979 cites W312214099 @default.
• W1965576979 cites W93363154 @default.
• W1965576979 doi "https://doi.org/10.1182/blood-2005-03-1076" @default.
• W1965576979 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1895059" @default.
• W1965576979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16046523" @default.
• W1965576979 hasPublicationYear "2005" @default.
• W1965576979 type Work @default.
• W1965576979 sameAs 1965576979 @default.
• W1965576979 citedByCount "10" @default.
• W1965576979 countsByYear W19655769792013 @default.
• W1965576979 countsByYear W19655769792014 @default.
• W1965576979 countsByYear W19655769792016 @default.
• W1965576979 countsByYear W19655769792017 @default.
• W1965576979 crossrefType "journal-article" @default.
• W1965576979 hasAuthorship W1965576979A5040296760 @default.
• W1965576979 hasAuthorship W1965576979A5051642123 @default.
• W1965576979 hasAuthorship W1965576979A5061423789 @default.
• W1965576979 hasAuthorship W1965576979A5068289010 @default.
• W1965576979 hasAuthorship W1965576979A5069156105 @default.
• W1965576979 hasAuthorship W1965576979A5078184468 @default.
• W1965576979 hasAuthorship W1965576979A5084498101 @default.
• W1965576979 hasBestOaLocation W19655769791 @default.
• W1965576979 hasConcept C104317684 @default.
• W1965576979 hasConcept C137061746 @default.
• W1965576979 hasConcept C140704245 @default.
• W1965576979 hasConcept C143065580 @default.
• W1965576979 hasConcept C147483822 @default.
• W1965576979 hasConcept C153911025 @default.
• W1965576979 hasConcept C159047783 @default.
• W1965576979 hasConcept C159654299 @default.
• W1965576979 hasConcept C202751555 @default.
• W1965576979 hasConcept C203014093 @default.
• W1965576979 hasConcept C2522874641 @default.
• W1965576979 hasConcept C2779562191 @default.
• W1965576979 hasConcept C2780868878 @default.
• W1965576979 hasConcept C54355233 @default.
• W1965576979 hasConcept C86803240 @default.
• W1965576979 hasConceptScore W1965576979C104317684 @default.
• W1965576979 hasConceptScore W1965576979C137061746 @default.
• W1965576979 hasConceptScore W1965576979C140704245 @default.
• W1965576979 hasConceptScore W1965576979C143065580 @default.
• W1965576979 hasConceptScore W1965576979C147483822 @default.
• W1965576979 hasConceptScore W1965576979C153911025 @default.
• W1965576979 hasConceptScore W1965576979C159047783 @default.
• W1965576979 hasConceptScore W1965576979C159654299 @default.
• W1965576979 hasConceptScore W1965576979C202751555 @default.

• next