FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965597989> ?p ?o ?g. }

• W1965597989 endingPage "10" @default.
• W1965597989 startingPage "1" @default.
• W1965597989 abstract "Parasitic infections are prevalent in both tropical and subtropical areas. Most of the affected and/or exposed populations are living in developing countries where control measures are lacking or inadequately applied. Although significant progress has been made in our understanding of the immune response to parasites, no definitive step has yet been successfully done in terms of operational vaccines against parasitic diseases. Evidence accumulated during the past few years suggests that the pathology observed during parasitic infections is in part due to deregulation of normal components of the immune system, mainly cytokines, antibodies, and immune effector cell populations. A large number of studies that illustrate how parasites can modify the host immune system for their own benefit have been reported in both metazoan and protozoan parasites. The first line of defense against foreign organisms is barrier tissue such as skin, humoral factors, for instance the complement system and pentraxin, which upon activation of the complement cascade facilitate pathogen recognition by cells of innate immunity such as macrophages and DC. However, all the major groups of parasites studied have been shown to contain and/or to release factors, which interfere with both arms of the host immune system. Even some astonishing observations relate to the production by some parasites of orthologues of mammalian cytokines. Furthermore, chronic parasitic infections have led to the immunosuppressive environment that correlates with increased levels of myeloid and T suppressor cells that may limit the success of immunotherapeutic strategies based on vaccination. This minireview briefly analyzes some of the current data related to the regulatory cells and molecules derived from parasites that affect cellular function and contribute to the polarization of the immune response of the host. Special attention is given to some of the data from our laboratory illustrating the role of immunomodulatory factors released by protozoan parasites, in the induction and perpetuation of chronic disease." @default.
• W1965597989 created "2016-06-24" @default.
• W1965597989 creator A5004933103 @default.
• W1965597989 date "2007-01-01" @default.
• W1965597989 modified "2023-09-30" @default.
• W1965597989 title "Regulatory Cells and Immunosuppressive Cytokines: Parasite-Derived Factors Induce Immune Polarization" @default.
• W1965597989 cites W128744027 @default.
• W1965597989 cites W1489889255 @default.
• W1965597989 cites W1506279744 @default.
• W1965597989 cites W1515615230 @default.
• W1965597989 cites W1525978917 @default.
• W1965597989 cites W1530044612 @default.
• W1965597989 cites W1540820582 @default.
• W1965597989 cites W1595602422 @default.
• W1965597989 cites W1603126127 @default.
• W1965597989 cites W1605273522 @default.
• W1965597989 cites W1611284225 @default.
• W1965597989 cites W1619437296 @default.
• W1965597989 cites W1639393197 @default.
• W1965597989 cites W1664456366 @default.
• W1965597989 cites W1865580510 @default.
• W1965597989 cites W1873406086 @default.
• W1965597989 cites W1917555508 @default.
• W1965597989 cites W1930671797 @default.
• W1965597989 cites W1934025219 @default.
• W1965597989 cites W1944304173 @default.
• W1965597989 cites W1957298029 @default.
• W1965597989 cites W1964073484 @default.
• W1965597989 cites W1970282643 @default.
• W1965597989 cites W1972989532 @default.
• W1965597989 cites W1978689070 @default.
• W1965597989 cites W1978988160 @default.
• W1965597989 cites W1980229223 @default.
• W1965597989 cites W1982221602 @default.
• W1965597989 cites W1987371296 @default.
• W1965597989 cites W1992801869 @default.
• W1965597989 cites W1992820290 @default.
• W1965597989 cites W1996924389 @default.
• W1965597989 cites W2000227658 @default.
• W1965597989 cites W2002006009 @default.
• W1965597989 cites W2002301397 @default.
• W1965597989 cites W2004011150 @default.
• W1965597989 cites W2005600708 @default.
• W1965597989 cites W2008083174 @default.
• W1965597989 cites W2011319298 @default.
• W1965597989 cites W2018173725 @default.
• W1965597989 cites W2019814232 @default.
• W1965597989 cites W2023659884 @default.
• W1965597989 cites W2025273988 @default.
• W1965597989 cites W2032917683 @default.
• W1965597989 cites W2037378787 @default.
• W1965597989 cites W2039664957 @default.
• W1965597989 cites W2040164466 @default.
• W1965597989 cites W2041352234 @default.
• W1965597989 cites W2048055969 @default.
• W1965597989 cites W2062173423 @default.
• W1965597989 cites W2062359227 @default.
• W1965597989 cites W2062471925 @default.
• W1965597989 cites W2066535150 @default.
• W1965597989 cites W2068843087 @default.
• W1965597989 cites W2068980119 @default.
• W1965597989 cites W2069412263 @default.
• W1965597989 cites W2069546240 @default.
• W1965597989 cites W2077701449 @default.
• W1965597989 cites W2082108487 @default.
• W1965597989 cites W2083241834 @default.
• W1965597989 cites W2088118252 @default.
• W1965597989 cites W2088119998 @default.
• W1965597989 cites W2091248310 @default.
• W1965597989 cites W2101230909 @default.
• W1965597989 cites W2108479730 @default.
• W1965597989 cites W2111345507 @default.
• W1965597989 cites W2116082836 @default.
• W1965597989 cites W2116394003 @default.
• W1965597989 cites W2118016322 @default.
• W1965597989 cites W2121596012 @default.
• W1965597989 cites W2124621398 @default.
• W1965597989 cites W2124829361 @default.
• W1965597989 cites W2125644509 @default.
• W1965597989 cites W2127432084 @default.
• W1965597989 cites W2129591033 @default.
• W1965597989 cites W2134231162 @default.
• W1965597989 cites W2134837867 @default.
• W1965597989 cites W2139191751 @default.
• W1965597989 cites W2141383323 @default.
• W1965597989 cites W2145152273 @default.
• W1965597989 cites W2145871366 @default.
• W1965597989 cites W2163569408 @default.
• W1965597989 cites W2165199797 @default.
• W1965597989 cites W2165972039 @default.
• W1965597989 cites W2167122047 @default.
• W1965597989 cites W2167318411 @default.
• W1965597989 cites W2168516002 @default.
• W1965597989 cites W2168985658 @default.
• W1965597989 cites W2169180723 @default.
• W1965597989 cites W2169339033 @default.
• W1965597989 cites W2170323587 @default.
• W1965597989 cites W2341099389 @default.

• next