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- W1965605847 abstract "Maturing T cells with a high affinity for self-antigens presented in the thymus are deleted in the process of negative selection. Although the expression of various tissue-specific antigens has been described in the thymus, it is still controversial what fraction of all self-antigens induces tolerance by this mechanism. We demonstrate that the limited duration of the negative selection phase imposes a constraint on the number of self-peptides that can be reliably selected against. The analysis supports the theory that negative selection is confined to the subset of peptides produced by dendritic cells." @default.
- W1965605847 created "2016-06-24" @default.
- W1965605847 creator A5054236642 @default.
- W1965605847 creator A5063657532 @default.
- W1965605847 date "2003-03-01" @default.
- W1965605847 modified "2023-10-12" @default.
- W1965605847 title "Quantitative constraints on the scope of negative selection" @default.
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- W1965605847 doi "https://doi.org/10.1016/s1471-4906(03)00028-0" @default.
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