FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965614114> ?p ?o ?g. }

• W1965614114 endingPage "477" @default.
• W1965614114 startingPage "464" @default.
• W1965614114 abstract "Recessive mutations in the amyotrophic lateral sclerosis 2 ( ALS2 ) gene have been linked to juvenile‐onset ALS 2. Although one of the molecular functions of the ALS 2 protein is clearly the activation of R ab5, the mechanisms underlying the selective dysfunction and degeneration of motor neurons in vivo remain to be fully understood. Here, we focused on the ALS2 homologue of D rosophila melanogaster , isolated two independent deletions, and systematically compared phenotypes of the mutants with those of animals in which R ab5 function in identified neurons was abrogated. In the dALS2 mutant flies, we found that the stereotypic axonal and dendritic morphologies of neurons shared some features with those in Rab5‐deficient flies, but the dALS2 mutant phenotypes were much milder. We also found that the abrogation of Rab5 function in motor neurons strongly depressed the locomotion activity of adults, resembling the behavior of aged dALS2 mutants. Importantly, this age‐dependent locomotion deficit of dALS2 mutants was restored to normal by expressing the dALS2 transgene in a wide range of tissues. This finding provided a platform where we could potentially identify particular cell types responsible for the phenotype by tissue‐specific rescue experiments. We discuss our results and the future usage of the dALS2 mutant as a new ALS model." @default.
• W1965614114 created "2016-06-24" @default.
• W1965614114 creator A5006372948 @default.
• W1965614114 creator A5008976898 @default.
• W1965614114 creator A5053334034 @default.
• W1965614114 creator A5085662694 @default.
• W1965614114 date "2014-04-07" @default.
• W1965614114 modified "2023-10-04" @default.
• W1965614114 title "Age-dependent deterioration of locomotion in<i>Drosophila melanogaster</i>deficient in the homologue of<i>amyotrophic lateral sclerosis 2</i>" @default.
• W1965614114 cites W1605911181 @default.
• W1965614114 cites W1934152683 @default.
• W1965614114 cites W1964320153 @default.
• W1965614114 cites W1965841021 @default.
• W1965614114 cites W1966587953 @default.
• W1965614114 cites W1967119663 @default.
• W1965614114 cites W1967809393 @default.
• W1965614114 cites W1969292147 @default.
• W1965614114 cites W1970895551 @default.
• W1965614114 cites W1977440353 @default.
• W1965614114 cites W1990744482 @default.
• W1965614114 cites W2002439648 @default.
• W1965614114 cites W2006254635 @default.
• W1965614114 cites W2006805865 @default.
• W1965614114 cites W2008255270 @default.
• W1965614114 cites W2013469333 @default.
• W1965614114 cites W2014829450 @default.
• W1965614114 cites W2018538469 @default.
• W1965614114 cites W2020808982 @default.
• W1965614114 cites W2025044590 @default.
• W1965614114 cites W2033158384 @default.
• W1965614114 cites W2038167955 @default.
• W1965614114 cites W2042252387 @default.
• W1965614114 cites W2043210246 @default.
• W1965614114 cites W2046951215 @default.
• W1965614114 cites W2051370920 @default.
• W1965614114 cites W2054938383 @default.
• W1965614114 cites W2056164193 @default.
• W1965614114 cites W2065943966 @default.
• W1965614114 cites W2067015275 @default.
• W1965614114 cites W2073397397 @default.
• W1965614114 cites W2074189105 @default.
• W1965614114 cites W2076126100 @default.
• W1965614114 cites W2076445219 @default.
• W1965614114 cites W2080498871 @default.
• W1965614114 cites W2082815622 @default.
• W1965614114 cites W2091145925 @default.
• W1965614114 cites W2092098765 @default.
• W1965614114 cites W2093262727 @default.
• W1965614114 cites W2104288176 @default.
• W1965614114 cites W2110643873 @default.
• W1965614114 cites W2119227574 @default.
• W1965614114 cites W2126871157 @default.
• W1965614114 cites W2128573075 @default.
• W1965614114 cites W2128815118 @default.
• W1965614114 cites W2136942907 @default.
• W1965614114 cites W2139849649 @default.
• W1965614114 cites W2144729254 @default.
• W1965614114 cites W2146840136 @default.
• W1965614114 cites W2148247362 @default.
• W1965614114 cites W2159154141 @default.
• W1965614114 cites W2159289924 @default.
• W1965614114 cites W2163256056 @default.
• W1965614114 cites W2163311553 @default.
• W1965614114 cites W2164687214 @default.
• W1965614114 cites W2172055712 @default.
• W1965614114 cites W2292454805 @default.
• W1965614114 cites W4320301318 @default.
• W1965614114 doi "https://doi.org/10.1111/gtc.12146" @default.
• W1965614114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24702731" @default.
• W1965614114 hasPublicationYear "2014" @default.
• W1965614114 type Work @default.
• W1965614114 sameAs 1965614114 @default.
• W1965614114 citedByCount "7" @default.
• W1965614114 countsByYear W19656141142015 @default.
• W1965614114 countsByYear W19656141142017 @default.
• W1965614114 countsByYear W19656141142018 @default.
• W1965614114 countsByYear W19656141142019 @default.
• W1965614114 countsByYear W19656141142021 @default.
• W1965614114 countsByYear W19656141142022 @default.
• W1965614114 crossrefType "journal-article" @default.
• W1965614114 hasAuthorship W1965614114A5006372948 @default.
• W1965614114 hasAuthorship W1965614114A5008976898 @default.
• W1965614114 hasAuthorship W1965614114A5053334034 @default.
• W1965614114 hasAuthorship W1965614114A5085662694 @default.
• W1965614114 hasBestOaLocation W19656141141 @default.
• W1965614114 hasConcept C102230213 @default.
• W1965614114 hasConcept C104317684 @default.
• W1965614114 hasConcept C127716648 @default.
• W1965614114 hasConcept C142724271 @default.
• W1965614114 hasConcept C143065580 @default.
• W1965614114 hasConcept C169760540 @default.
• W1965614114 hasConcept C2779134260 @default.
• W1965614114 hasConcept C2780104201 @default.
• W1965614114 hasConcept C2780596555 @default.
• W1965614114 hasConcept C501734568 @default.
• W1965614114 hasConcept C54355233 @default.
• W1965614114 hasConcept C71924100 @default.
• W1965614114 hasConcept C86803240 @default.

• next