Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965614813> ?p ?o ?g. }
- W1965614813 endingPage "835" @default.
- W1965614813 startingPage "825" @default.
- W1965614813 abstract "Recent high-resolution studies of kinetochore structure have transformed the way researchers think about this crucial macro-molecular complex, which is essential for ensuring chromosome segregation occurs faithfully during cell division. Kinetochores mediate the interaction between chromosomes and the plus-ends of dynamic spindle microtubules and control the timing of anaphase onset by regulating the spindle assembly checkpoint (SAC). There is much debate in the SAC research community as to whether mitotic cells sense only microtubule attachment at the kinetochore, or both attachment and tension, before committing to anaphase. In this Commentary, we present a brief history of the tension-versus-attachment debate, summarize recent advances in our understanding of kinetochore structure and focus on the implications of a phenomenon known as intrakinetochore stretch for SAC regulation. We also hypothesize how intrakinetochore stretch might impact SAC function by regulating both microtubule attachment stability and the localization and activity of checkpoint components at the kinetochore." @default.
- W1965614813 created "2016-06-24" @default.
- W1965614813 creator A5008667372 @default.
- W1965614813 creator A5011106090 @default.
- W1965614813 date "2010-03-15" @default.
- W1965614813 modified "2023-09-23" @default.
- W1965614813 title "Welcome to a new kind of tension: translating kinetochore mechanics into a wait-anaphase signal" @default.
- W1965614813 cites W1483395792 @default.
- W1965614813 cites W1508230049 @default.
- W1965614813 cites W1867836395 @default.
- W1965614813 cites W1965308596 @default.
- W1965614813 cites W1965475092 @default.
- W1965614813 cites W1966521331 @default.
- W1965614813 cites W1967635736 @default.
- W1965614813 cites W1967696278 @default.
- W1965614813 cites W1969236463 @default.
- W1965614813 cites W1974559008 @default.
- W1965614813 cites W1975648894 @default.
- W1965614813 cites W1979783832 @default.
- W1965614813 cites W1980779852 @default.
- W1965614813 cites W1982341304 @default.
- W1965614813 cites W1983412918 @default.
- W1965614813 cites W1986157458 @default.
- W1965614813 cites W1990300808 @default.
- W1965614813 cites W1991101546 @default.
- W1965614813 cites W1996991848 @default.
- W1965614813 cites W2005510835 @default.
- W1965614813 cites W2005717642 @default.
- W1965614813 cites W2007388359 @default.
- W1965614813 cites W2010582190 @default.
- W1965614813 cites W2012212144 @default.
- W1965614813 cites W2015754578 @default.
- W1965614813 cites W2017518375 @default.
- W1965614813 cites W2017616865 @default.
- W1965614813 cites W2018711267 @default.
- W1965614813 cites W2029326415 @default.
- W1965614813 cites W2032967041 @default.
- W1965614813 cites W2034700471 @default.
- W1965614813 cites W2045539221 @default.
- W1965614813 cites W2045658203 @default.
- W1965614813 cites W2048309959 @default.
- W1965614813 cites W2048938594 @default.
- W1965614813 cites W2050415386 @default.
- W1965614813 cites W2051533055 @default.
- W1965614813 cites W2055743739 @default.
- W1965614813 cites W2058703970 @default.
- W1965614813 cites W2060941242 @default.
- W1965614813 cites W2062117947 @default.
- W1965614813 cites W2062963733 @default.
- W1965614813 cites W2067897696 @default.
- W1965614813 cites W2071156666 @default.
- W1965614813 cites W2071259832 @default.
- W1965614813 cites W2074955549 @default.
- W1965614813 cites W2079741946 @default.
- W1965614813 cites W2079987996 @default.
- W1965614813 cites W2082250120 @default.
- W1965614813 cites W2086283062 @default.
- W1965614813 cites W2088006036 @default.
- W1965614813 cites W2088118120 @default.
- W1965614813 cites W2089638314 @default.
- W1965614813 cites W2089844705 @default.
- W1965614813 cites W2092401565 @default.
- W1965614813 cites W2098318897 @default.
- W1965614813 cites W2101712721 @default.
- W1965614813 cites W2102673682 @default.
- W1965614813 cites W2102770794 @default.
- W1965614813 cites W2102960342 @default.
- W1965614813 cites W2105989492 @default.
- W1965614813 cites W2106869142 @default.
- W1965614813 cites W2106942695 @default.
- W1965614813 cites W2107261750 @default.
- W1965614813 cites W2109322693 @default.
- W1965614813 cites W2114460232 @default.
- W1965614813 cites W2117598480 @default.
- W1965614813 cites W2119904249 @default.
- W1965614813 cites W2126203546 @default.
- W1965614813 cites W2126683450 @default.
- W1965614813 cites W2126697894 @default.
- W1965614813 cites W2127315808 @default.
- W1965614813 cites W2127660818 @default.
- W1965614813 cites W2132903556 @default.
- W1965614813 cites W2133492742 @default.
- W1965614813 cites W2133503471 @default.
- W1965614813 cites W2134160832 @default.
- W1965614813 cites W2137141545 @default.
- W1965614813 cites W2139009573 @default.
- W1965614813 cites W2142610451 @default.
- W1965614813 cites W2142919879 @default.
- W1965614813 cites W2143522907 @default.
- W1965614813 cites W2147903962 @default.
- W1965614813 cites W2151248947 @default.
- W1965614813 cites W2154241215 @default.
- W1965614813 cites W2155225188 @default.
- W1965614813 cites W2157672693 @default.
- W1965614813 cites W2159877783 @default.
- W1965614813 cites W2161226668 @default.
- W1965614813 cites W2162768809 @default.
- W1965614813 cites W2163571710 @default.