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• W1965616857 endingPage "896" @default.
• W1965616857 startingPage "891" @default.
• W1965616857 abstract "Oxytocin (OT) receptor binding in the ventromedial hypothalamic nucleus is regulated by testosterone (T) in male rats. However, T is metabolized in the brain, and many of the central effects of T are mediated by its metabolites. The experiments reported here were designed to determine whether T affects OT receptor binding directly or through the action of its metabolites 17 beta-estradiol and 5 alpha-dihydrotestosterone. Adult male rats were either sham operated or castrated and treated 1 week later with T propionate (TP), 17 beta-estradiol benzoate (EB), dihydrotestosterone benzoate (DHTB), DHTB plus EB, or oil. OT receptor binding was assessed autoradiographically using [125I]d(CH2)5[Tyr(Me)2,Thr4,Tyr-NH2(9)]OVT. In addition, seminal vesicle weights were measured as an index of androgenic activity. These experiments showed that TP and DHTB plus EB increased OT receptor binding in the ventromedial hypothalamic nucleus to the levels in intact males. Treatment with EB alone partially reinstated binding to the levels in intact males, while DHTB treatment was without effect. Castrated males treated with either TP or DHTB had seminal vesicle weights comparable to those of gonadally intact males and greater than those of animals in all other steroid conditions, indicating that sufficient levels of circulating steroids were attained in these groups. These data suggest that the induction of hypothalamic OT receptor binding by T is the result of the combined actions of estradiol and dihydrotestosterone. However, the mechanism underlying this interaction is unknown." @default.
• W1965616857 created "2016-06-24" @default.
• W1965616857 creator A5004790871 @default.
• W1965616857 creator A5035103174 @default.
• W1965616857 creator A5039837577 @default.
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• W1965616857 date "1991-02-01" @default.
• W1965616857 modified "2023-09-26" @default.
• W1965616857 title "The Regulation of Oxytocin Receptor Binding in the Ventromedial Hypothalaimic Nucleus by Testosterone and Its Metabolites*" @default.
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• W1965616857 doi "https://doi.org/10.1210/endo-128-2-891" @default.
• W1965616857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1846593" @default.
• W1965616857 hasPublicationYear "1991" @default.
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