FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965617271> ?p ?o ?g. }

• W1965617271 endingPage "456" @default.
• W1965617271 startingPage "449" @default.
• W1965617271 abstract "Trypanosomatids present unusual organelles, such as the kinetoplast that contains the mitochondrial DNA arranged in catenated circles. The nucleus of these protozoa presents distinct domains during interphase as well as a closed mitosis. DNA topoisomerases modulate the topological state of DNA by regulating supercoiling of the double-stranded DNA during replication, transcription, recombination and repair. Because topoisomerases play essential roles in cellular processes, they constitute a potential target for antitumour and antimicrobial drugs. In this study, the effects of various topoisomerase inhibitors and DNA-binding drugs were tested on the cellular proliferation and ultrastructure of the Trypanosoma cruzi epimastigote form Blastocrithidia culicis was used as a comparative model, which has a more relaxed kinetoplast DNA (kDNA) organization. The results showed that the eukaryotic topoisomerase I inhibitors camptothecin and rebeccamycin were the most effective compounds in the arrest of T. cruzi proliferation. Of the eukaryotic topoisomerase II inhibitors, mitoxantrone, but not merbarone, was effective against cell proliferation. The prokaryotic topoisomerase II inhibitors norfloxacin and enoxacin targeted the kinetoplast specifically, thus promoting ultrastructural kDNA rearrangement in B. culicis. Of the DNA-binding drugs, berenil caused remarkable kDNA disorganization. With the exception of camptothecin, there have been no previous evaluations of the compounds tested here on trypanosomatid ultrastructure. In conclusion, inhibitors of the same class may have different effects on trypanosomatid proliferation and ultrastructure. The results obtained in this work may help to reveal the mechanism of action of different topoisomerase inhibitors in trypanosomatids." @default.
• W1965617271 created "2016-06-24" @default.
• W1965617271 creator A5008267222 @default.
• W1965617271 creator A5014123016 @default.
• W1965617271 creator A5048024223 @default.
• W1965617271 creator A5082039899 @default.
• W1965617271 creator A5089667127 @default.
• W1965617271 date "2011-05-01" @default.
• W1965617271 modified "2023-10-11" @default.
• W1965617271 title "Effect of topoisomerase inhibitors and DNA-binding drugs on the cell proliferation and ultrastructure of Trypanosoma cruzi" @default.
• W1965617271 cites W1968355846 @default.
• W1965617271 cites W1970759602 @default.
• W1965617271 cites W1972477749 @default.
• W1965617271 cites W1974589615 @default.
• W1965617271 cites W1978426538 @default.
• W1965617271 cites W1979526745 @default.
• W1965617271 cites W1979936660 @default.
• W1965617271 cites W1981976181 @default.
• W1965617271 cites W1982455177 @default.
• W1965617271 cites W1982915722 @default.
• W1965617271 cites W1984696105 @default.
• W1965617271 cites W1984702947 @default.
• W1965617271 cites W1992516446 @default.
• W1965617271 cites W1994199781 @default.
• W1965617271 cites W1999741378 @default.
• W1965617271 cites W2010676078 @default.
• W1965617271 cites W2018450329 @default.
• W1965617271 cites W2019169514 @default.
• W1965617271 cites W2020661761 @default.
• W1965617271 cites W2022500414 @default.
• W1965617271 cites W2023481455 @default.
• W1965617271 cites W2024322753 @default.
• W1965617271 cites W2024923808 @default.
• W1965617271 cites W2025133398 @default.
• W1965617271 cites W2025631179 @default.
• W1965617271 cites W2029470172 @default.
• W1965617271 cites W2032020572 @default.
• W1965617271 cites W2034541418 @default.
• W1965617271 cites W2037400794 @default.
• W1965617271 cites W2042099308 @default.
• W1965617271 cites W2045594331 @default.
• W1965617271 cites W2066942633 @default.
• W1965617271 cites W2071176610 @default.
• W1965617271 cites W2078294344 @default.
• W1965617271 cites W2079581280 @default.
• W1965617271 cites W2082572671 @default.
• W1965617271 cites W2097459416 @default.
• W1965617271 cites W2100933698 @default.
• W1965617271 cites W2104749119 @default.
• W1965617271 cites W2117513644 @default.
• W1965617271 cites W2124624490 @default.
• W1965617271 cites W2132500613 @default.
• W1965617271 cites W2137779521 @default.
• W1965617271 cites W2144704949 @default.
• W1965617271 cites W2153383148 @default.
• W1965617271 cites W2153384219 @default.
• W1965617271 cites W2154944325 @default.
• W1965617271 cites W2155904896 @default.
• W1965617271 cites W2160948762 @default.
• W1965617271 cites W2167520063 @default.
• W1965617271 cites W2311663614 @default.
• W1965617271 cites W2409114153 @default.
• W1965617271 cites W4233567369 @default.
• W1965617271 cites W97051736 @default.
• W1965617271 doi "https://doi.org/10.1016/j.ijantimicag.2010.11.031" @default.
• W1965617271 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21292448" @default.
• W1965617271 hasPublicationYear "2011" @default.
• W1965617271 type Work @default.
• W1965617271 sameAs 1965617271 @default.
• W1965617271 citedByCount "38" @default.
• W1965617271 countsByYear W19656172712012 @default.
• W1965617271 countsByYear W19656172712013 @default.
• W1965617271 countsByYear W19656172712014 @default.
• W1965617271 countsByYear W19656172712015 @default.
• W1965617271 countsByYear W19656172712016 @default.
• W1965617271 countsByYear W19656172712017 @default.
• W1965617271 countsByYear W19656172712018 @default.
• W1965617271 countsByYear W19656172712019 @default.
• W1965617271 countsByYear W19656172712020 @default.
• W1965617271 countsByYear W19656172712021 @default.
• W1965617271 countsByYear W19656172712022 @default.
• W1965617271 countsByYear W19656172712023 @default.
• W1965617271 crossrefType "journal-article" @default.
• W1965617271 hasAuthorship W1965617271A5008267222 @default.
• W1965617271 hasAuthorship W1965617271A5014123016 @default.
• W1965617271 hasAuthorship W1965617271A5048024223 @default.
• W1965617271 hasAuthorship W1965617271A5082039899 @default.
• W1965617271 hasAuthorship W1965617271A5089667127 @default.
• W1965617271 hasBestOaLocation W19656172711 @default.
• W1965617271 hasConcept C136764020 @default.
• W1965617271 hasConcept C147897179 @default.
• W1965617271 hasConcept C153911025 @default.
• W1965617271 hasConcept C2776027055 @default.
• W1965617271 hasConcept C2777625466 @default.
• W1965617271 hasConcept C2779682216 @default.
• W1965617271 hasConcept C41008148 @default.
• W1965617271 hasConcept C552990157 @default.
• W1965617271 hasConcept C55493867 @default.

• next