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• W1965620797 abstract "The endocannabinoid system is involved in multiple physiological functions including reward. Cannabinoids potently control the activity of midbrain dopamine cells, but the contribution of cortical projections in this phenomenon is unclear. We show that the bed nucleus of the stria terminalis (BNST) efficient relays cortical excitation to dopamine neurons of the ventral tegmental area (VTA). Anatomical and in vivo electrophysiological evidence demonstrate that excitatory projections arising exclusively from the infralimbic cortex converge on BNST neurons, which in turn project to and excite >80% VTA dopamine cells. At the ultrastructural level, cannabinoid type 1 receptors are detected within the BNST on axon terminals arising from the infralimbic cortex. We found that intra-BNST infusion of a cannabinoid agonist inhibits the firing of dopamine cells evoked by stimulation of the infralimbic cortex. Our data identify a new neuronal substrate for the actions of cannabinoids in the reward pathway." @default.
• W1965620797 created "2016-06-24" @default.
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• W1965620797 date "2008-10-15" @default.
• W1965620797 modified "2023-10-01" @default.
• W1965620797 title "Cannabinoid Receptors in the Bed Nucleus of the Stria Terminalis Control Cortical Excitation of Midbrain Dopamine Cells<i>In Vivo</i>" @default.
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• W1965620797 doi "https://doi.org/10.1523/jneurosci.2291-08.2008" @default.
• W1965620797 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6671338" @default.
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