FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965623211> ?p ?o ?g. }

• W1965623211 endingPage "1307" @default.
• W1965623211 startingPage "1302" @default.
• W1965623211 abstract "Background Central adrenal insufficiency is observed after cranial radiation therapy for cancer. Screening at risk patients is recommended, but the best screening strategy is unknown. Methods A retrospective review of pediatric cancer survivors who underwent hypothalamic/pituitary/adrenal axis testing was conducted. Data included: cancer diagnosis, radiotherapy dose, other endocrinopathies, and adrenal function testing. Adrenal testing included sequential low-dose corticotropin test (LDCT) and standard-dose corticotropin test (SDCT). 8 a.m. serum cortisol levels were compared to LDCT results. LDCT results were compared by radiotheroapy dose and according to the presence of endocrine comorbidities. Results Seventy-eight subjects (56% male, mean age at diagnosis 6.5 years) underwent testing. 67.9% had been treated with radiotherapy to the hypothalamus/pituitary. Mean time to diagnosis of adrenal insufficiency was 6.8 years after cancer diagnosis. Adequate adrenal function was found in 65% of patients by LDCT and 89% by SDCT. Only 21% of patients had basal serum cortisols collected at 8 a.m. Agreement between 8 a.m. baseline cortisol and LDCT was fair. Agreement between random baseline cortisol and LDCT was poor. Prevalence of central adrenal insufficiency diagnosed by LDCT increased with radiotherapy dose (8% for 10–19.9 Gy; 83% for ≥40 Gy) and the number of endocrine comorbidities. Conclusions In pediatric cancer survivors, central adrenal insufficiency was common even in patients receiving <40 Gy to the hypothalamus/pituitary. We recommend use of LDCT, not 8 a.m. serum cortisol to screen patients who received >30 Gy of radiotherapy and those with other central endocrinopathies. Pediatr Blood Cancer 2009; 53:1302–1307. © 2009 Wiley-Liss, Inc." @default.
• W1965623211 created "2016-06-24" @default.
• W1965623211 creator A5028994945 @default.
• W1965623211 creator A5047469126 @default.
• W1965623211 creator A5073386087 @default.
• W1965623211 creator A5078950754 @default.
• W1965623211 creator A5087007852 @default.
• W1965623211 date "2009-12-15" @default.
• W1965623211 modified "2023-10-16" @default.
• W1965623211 title "Adrenal function testing in pediatric cancer survivors" @default.
• W1965623211 cites W1561351730 @default.
• W1965623211 cites W1973786227 @default.
• W1965623211 cites W1978352504 @default.
• W1965623211 cites W1982468989 @default.
• W1965623211 cites W1993377159 @default.
• W1965623211 cites W2021169891 @default.
• W1965623211 cites W2028514243 @default.
• W1965623211 cites W2029546900 @default.
• W1965623211 cites W2036461565 @default.
• W1965623211 cites W2044274662 @default.
• W1965623211 cites W2069133047 @default.
• W1965623211 cites W2075461701 @default.
• W1965623211 cites W2089433743 @default.
• W1965623211 cites W2089651359 @default.
• W1965623211 cites W2110535212 @default.
• W1965623211 cites W2112993156 @default.
• W1965623211 cites W2133941042 @default.
• W1965623211 cites W2138622268 @default.
• W1965623211 cites W2139770091 @default.
• W1965623211 cites W2140947725 @default.
• W1965623211 cites W2148389327 @default.
• W1965623211 cites W2149192255 @default.
• W1965623211 cites W2149262344 @default.
• W1965623211 cites W2159495622 @default.
• W1965623211 cites W2166962064 @default.
• W1965623211 cites W2171246100 @default.
• W1965623211 cites W2172241914 @default.
• W1965623211 doi "https://doi.org/10.1002/pbc.22208" @default.
• W1965623211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19637328" @default.
• W1965623211 hasPublicationYear "2009" @default.
• W1965623211 type Work @default.
• W1965623211 sameAs 1965623211 @default.
• W1965623211 citedByCount "35" @default.
• W1965623211 countsByYear W19656232112012 @default.
• W1965623211 countsByYear W19656232112013 @default.
• W1965623211 countsByYear W19656232112014 @default.
• W1965623211 countsByYear W19656232112015 @default.
• W1965623211 countsByYear W19656232112016 @default.
• W1965623211 countsByYear W19656232112017 @default.
• W1965623211 countsByYear W19656232112018 @default.
• W1965623211 countsByYear W19656232112019 @default.
• W1965623211 countsByYear W19656232112020 @default.
• W1965623211 countsByYear W19656232112021 @default.
• W1965623211 countsByYear W19656232112022 @default.
• W1965623211 crossrefType "journal-article" @default.
• W1965623211 hasAuthorship W1965623211A5028994945 @default.
• W1965623211 hasAuthorship W1965623211A5047469126 @default.
• W1965623211 hasAuthorship W1965623211A5073386087 @default.
• W1965623211 hasAuthorship W1965623211A5078950754 @default.
• W1965623211 hasAuthorship W1965623211A5087007852 @default.
• W1965623211 hasConcept C121608353 @default.
• W1965623211 hasConcept C126322002 @default.
• W1965623211 hasConcept C187212893 @default.
• W1965623211 hasConcept C2778129406 @default.
• W1965623211 hasConcept C2778491484 @default.
• W1965623211 hasConcept C2780546910 @default.
• W1965623211 hasConcept C2993561819 @default.
• W1965623211 hasConcept C46699223 @default.
• W1965623211 hasConcept C509974204 @default.
• W1965623211 hasConcept C71315377 @default.
• W1965623211 hasConcept C71924100 @default.
• W1965623211 hasConceptScore W1965623211C121608353 @default.
• W1965623211 hasConceptScore W1965623211C126322002 @default.
• W1965623211 hasConceptScore W1965623211C187212893 @default.
• W1965623211 hasConceptScore W1965623211C2778129406 @default.
• W1965623211 hasConceptScore W1965623211C2778491484 @default.
• W1965623211 hasConceptScore W1965623211C2780546910 @default.
• W1965623211 hasConceptScore W1965623211C2993561819 @default.
• W1965623211 hasConceptScore W1965623211C46699223 @default.
• W1965623211 hasConceptScore W1965623211C509974204 @default.
• W1965623211 hasConceptScore W1965623211C71315377 @default.
• W1965623211 hasConceptScore W1965623211C71924100 @default.
• W1965623211 hasIssue "7" @default.
• W1965623211 hasLocation W19656232111 @default.
• W1965623211 hasLocation W19656232112 @default.
• W1965623211 hasOpenAccess W1965623211 @default.
• W1965623211 hasPrimaryLocation W19656232111 @default.
• W1965623211 hasRelatedWork W1545440122 @default.
• W1965623211 hasRelatedWork W1965469500 @default.
• W1965623211 hasRelatedWork W1967618349 @default.
• W1965623211 hasRelatedWork W2018081626 @default.
• W1965623211 hasRelatedWork W2029809297 @default.
• W1965623211 hasRelatedWork W2072005731 @default.
• W1965623211 hasRelatedWork W2076107133 @default.
• W1965623211 hasRelatedWork W2623958695 @default.
• W1965623211 hasRelatedWork W2763664782 @default.
• W1965623211 hasRelatedWork W3154354038 @default.
• W1965623211 hasVolume "53" @default.

• next