Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965624244> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1965624244 abstract "Background and Aims: MicroRNAs (miRNAs) are short non-coding RNA whose expression levels have diagnostic and prognostic implications in cancer. However, the relevance of aberrantly expressed miRNAs to breast tumour-immune response has not been established. We aimed to assess the association between deregulated miRNAs and tumour immune response in breast molecular cancer subtypes. Methods: One hundred and seventy ductal infiltrating breast carcinomas (BC) (ER+/HER2− n=85, HER2+ n=40, ER−/HER2− n=45) were evaluated for the presence of cellular immune components by IHC assay. CD3, CD20 were used as markers for T lymphocytes infiltration (TIL), and B lymphocytes infiltration (BIL), respectively, whereas CD68 for the presence of tumour-associated macrophage (TAM). Total RNA (including miRNA) was extracted from all tumours and 32 highly specific miRNAs and 276 immune genes were evaluated by array and qRT-PCR assays. We derived an integrated immune miRNA-regulatory gene profile to tease out relationships of these genes as potential targets of specific miRNAs. In vitro experiments on BC cell lines were performed to confirm potential links between deregulated miRNAs and immune genes. Results: Lymphocytes infiltration (LI) was most common in HER2+ and ER−/HER2− BC samples ( P P miR-181 and miR-135a that were significantly associated with ER−/HER2− ( P P miR-181 and miR-135a showed an important association with distinct TIL and TAM components and specific immune genes. Importantly, preclinical data on BC cell lines demonstrated that miR-181 and miR-135a were able to regulate important cell immune-modulators such as SEMA3B and STAT6 signalling pathways, respectively. These 2 cellular pathways in turn were capable to regulate specific cascades of immune gene networks. Conclusion: We identified specific miRNAs associated with immune cellular components and immune-related tumour response in the 3 main molecular BC subtypes (ER+/HER2−, HER2+ and ER−/HER2). Aberrant expression of miR-181 and miR-135a can contribute to BC tumour immune response programs by regulating important gene targets such as SEMA3B and STAT6 signalling pathways in ER−/HER2− and HER2+ tumours, respectively. Modulation of miRNAs activating tumour immune response programs may have important implications for novel therapeutic strategies in BC. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P5-10-01." @default.
- W1965624244 created "2016-06-24" @default.
- W1965624244 creator A5004315502 @default.
- W1965624244 creator A5018454361 @default.
- W1965624244 creator A5019064357 @default.
- W1965624244 creator A5021113979 @default.
- W1965624244 creator A5028978581 @default.
- W1965624244 creator A5029640604 @default.
- W1965624244 creator A5034629153 @default.
- W1965624244 creator A5036094132 @default.
- W1965624244 creator A5041845308 @default.
- W1965624244 creator A5065721950 @default.
- W1965624244 creator A5066545923 @default.
- W1965624244 date "2012-12-15" @default.
- W1965624244 modified "2023-09-25" @default.
- W1965624244 title "Abstract P5-10-01: MicroRNAs −181and −135amodulate tumour infiltrating immune cell programs in distinct molecular breast cancer subtypes" @default.
- W1965624244 doi "https://doi.org/10.1158/0008-5472.sabcs12-p5-10-01" @default.
- W1965624244 hasPublicationYear "2012" @default.
- W1965624244 type Work @default.
- W1965624244 sameAs 1965624244 @default.
- W1965624244 citedByCount "0" @default.
- W1965624244 crossrefType "proceedings-article" @default.
- W1965624244 hasAuthorship W1965624244A5004315502 @default.
- W1965624244 hasAuthorship W1965624244A5018454361 @default.
- W1965624244 hasAuthorship W1965624244A5019064357 @default.
- W1965624244 hasAuthorship W1965624244A5021113979 @default.
- W1965624244 hasAuthorship W1965624244A5028978581 @default.
- W1965624244 hasAuthorship W1965624244A5029640604 @default.
- W1965624244 hasAuthorship W1965624244A5034629153 @default.
- W1965624244 hasAuthorship W1965624244A5036094132 @default.
- W1965624244 hasAuthorship W1965624244A5041845308 @default.
- W1965624244 hasAuthorship W1965624244A5065721950 @default.
- W1965624244 hasAuthorship W1965624244A5066545923 @default.
- W1965624244 hasConcept C104317684 @default.
- W1965624244 hasConcept C121608353 @default.
- W1965624244 hasConcept C145059251 @default.
- W1965624244 hasConcept C167672396 @default.
- W1965624244 hasConcept C18031839 @default.
- W1965624244 hasConcept C203014093 @default.
- W1965624244 hasConcept C204232928 @default.
- W1965624244 hasConcept C2778326572 @default.
- W1965624244 hasConcept C502942594 @default.
- W1965624244 hasConcept C530470458 @default.
- W1965624244 hasConcept C54355233 @default.
- W1965624244 hasConcept C86803240 @default.
- W1965624244 hasConcept C8891405 @default.
- W1965624244 hasConceptScore W1965624244C104317684 @default.
- W1965624244 hasConceptScore W1965624244C121608353 @default.
- W1965624244 hasConceptScore W1965624244C145059251 @default.
- W1965624244 hasConceptScore W1965624244C167672396 @default.
- W1965624244 hasConceptScore W1965624244C18031839 @default.
- W1965624244 hasConceptScore W1965624244C203014093 @default.
- W1965624244 hasConceptScore W1965624244C204232928 @default.
- W1965624244 hasConceptScore W1965624244C2778326572 @default.
- W1965624244 hasConceptScore W1965624244C502942594 @default.
- W1965624244 hasConceptScore W1965624244C530470458 @default.
- W1965624244 hasConceptScore W1965624244C54355233 @default.
- W1965624244 hasConceptScore W1965624244C86803240 @default.
- W1965624244 hasConceptScore W1965624244C8891405 @default.
- W1965624244 hasLocation W19656242441 @default.
- W1965624244 hasOpenAccess W1965624244 @default.
- W1965624244 hasPrimaryLocation W19656242441 @default.
- W1965624244 hasRelatedWork W1846509560 @default.
- W1965624244 hasRelatedWork W2006023010 @default.
- W1965624244 hasRelatedWork W2121086530 @default.
- W1965624244 hasRelatedWork W2151182769 @default.
- W1965624244 hasRelatedWork W2314445886 @default.
- W1965624244 hasRelatedWork W2319976253 @default.
- W1965624244 hasRelatedWork W2336339745 @default.
- W1965624244 hasRelatedWork W2567026559 @default.
- W1965624244 hasRelatedWork W2570270330 @default.
- W1965624244 hasRelatedWork W2593962594 @default.
- W1965624244 hasRelatedWork W2617032619 @default.
- W1965624244 hasRelatedWork W2899043754 @default.
- W1965624244 hasRelatedWork W2908006843 @default.
- W1965624244 hasRelatedWork W3034103088 @default.
- W1965624244 hasRelatedWork W3038856038 @default.
- W1965624244 hasRelatedWork W3047627967 @default.
- W1965624244 hasRelatedWork W3096663507 @default.
- W1965624244 hasRelatedWork W3125014991 @default.
- W1965624244 hasRelatedWork W3204721910 @default.
- W1965624244 hasRelatedWork W792017132 @default.
- W1965624244 isParatext "false" @default.
- W1965624244 isRetracted "false" @default.
- W1965624244 magId "1965624244" @default.
- W1965624244 workType "article" @default.