FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965631450> ?p ?o ?g. }

• W1965631450 endingPage "104" @default.
• W1965631450 startingPage "103" @default.
• W1965631450 abstract "Noninvasive imaging of the coronary arteries remains an ideal but as yet unachieved objective. A current surrogate for the latter approach is indirect evaluation by detection and quantitation of coronary artery calcification with electron beam computed tomography (EBCT). EBCT has attracted considerable attention and generated a growing body of data that provides an emerging perspective on the potential of this method to contribute to the detection of coronary artery disease (CAD). The status of methods to identify coronary artery calcification, of which EBCT is the major focus, was the subject of a recent Statement for Health Professionals from the American Heart Association (AHA) not long ago and its perspective is still useful.1 The statement summarized the subject of arterial calcium deposition, including its pathophysiology, detection, epidemiology, and applications of imaging methods. The association of arterial calcium deposition and atherosclerosis is well established. EBCT has extended understanding of this association by demonstrating a quantitative relationship between the amount of coronary artery calcium, plaque burden, and the presence of angiographic disease. It has been shown that over 90% of coronary arteries with stenoses >75% have calcium detectable by EBCT in contrast to only 20% of arteries with <50% stenosis2 and the calcified area measured by EBCT correlates with plaque volume.3 Further studies have evaluated the relation of coronary calcium to angiographically significant CAD and to the risk of coronary events. As with other noninvasive methods for detecting CAD, the sensitivity and specificity of EBCT for detection of coronary lesions and predicting prognosis depends on the population being tested. For EBCT, the highest combined sensitivity and specificity (70% for each) for detecting CAD is in middle-aged individuals (40–60 years old).4 In addition, sensitivity and specificity are dependent on the threshold calcium score, which provides a quantitative estimate of arterial calcium, rather than simply reporting its presence or absence.4 Although there is considerable overlap in the sensitivity and specificity of current noninvasive methods for detecting CAD and in predicting coronary events, it is noteworthy that absence of coronary calcium on EBCT examination has been associated with a benign prognosis while high coronary calcium scores correlate with increased coronary events.5 However, there was considerable overlap in clinical outcomes in patients with calcium scores in the middle range in this study of 501 symptomatic patients, in which the calcium score was a better predictor of coronary events than angiography. In asymptomatic patients, the utility of EBCT for determining prognosis is inconclusive. The risk of a CAD event increases with increasing calcium score but most events have been “soft” end points such as revascularization,6 which is physician-driven. Further, a recent study in high risk, asymptomatic subjects revealed similar predictive accuracy for CAD events by multiple risk factor analysis as by EBCT.7 EBCT has a number of advantages. It is readily performed, taking <20 minutes including quantitative calcium scoring. It is economical, costing one-half to one-third of a stress scintigram or stress echocardiogram and the radiation dose is 2–3 orders of magnitude less than that of a coronary angiogram. Despite these favorable aspects, current data are circumscribed by studies of selected populations and referral bias which preclude conclusions regarding general application of EBCT to the assessment of CAD. At this time, it can be concluded that the strongest relation between coronary artery calcium and CAD events is in symptomatic patients and, possibly, very high risk asymptomatic subjects. Important information regarding EBCT in predicting events in asymptomatic individuals will be forthcoming from the prospective MultiEthnic Study of Atherosclerosis (MESA). In symptomatic patients, EBCT has been sufficiently accurate for predicting angiographic CAD and clinical end points to be utilized as part of a cardiac evaluation performed by a physician knowledgeable in the interpretation and application of the results of this technique. It cannot currently be recommended as an alternative to well established methods of noninvasive testing in symptomatic patients. Finally, the role of EBCT as a screening method for asymptomatic subjects is currently unclear and must await further studies." @default.
• W1965631450 created "2016-06-24" @default.
• W1965631450 creator A5069460400 @default.
• W1965631450 date "2000-06-01" @default.
• W1965631450 modified "2023-10-14" @default.
• W1965631450 title "Calcium, Coronary Artery Disease, and EBCT" @default.
• W1965631450 cites W1964055985 @default.
• W1965631450 cites W2003768457 @default.
• W1965631450 cites W2024444522 @default.
• W1965631450 cites W2037205708 @default.
• W1965631450 cites W2042417256 @default.
• W1965631450 cites W2047347307 @default.
• W1965631450 cites W2072939639 @default.
• W1965631450 doi "https://doi.org/10.1111/j.1520-037x.2000.80368.x" @default.
• W1965631450 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11834926" @default.
• W1965631450 hasPublicationYear "2000" @default.
• W1965631450 type Work @default.
• W1965631450 sameAs 1965631450 @default.
• W1965631450 citedByCount "1" @default.
• W1965631450 crossrefType "journal-article" @default.
• W1965631450 hasAuthorship W1965631450A5069460400 @default.
• W1965631450 hasBestOaLocation W19656314501 @default.
• W1965631450 hasConcept C126322002 @default.
• W1965631450 hasConcept C126838900 @default.
• W1965631450 hasConcept C164705383 @default.
• W1965631450 hasConcept C2776820930 @default.
• W1965631450 hasConcept C2778213512 @default.
• W1965631450 hasConcept C2778742706 @default.
• W1965631450 hasConcept C2780309369 @default.
• W1965631450 hasConcept C2908647359 @default.
• W1965631450 hasConcept C2909917808 @default.
• W1965631450 hasConcept C2994533308 @default.
• W1965631450 hasConcept C71924100 @default.
• W1965631450 hasConcept C99454951 @default.
• W1965631450 hasConceptScore W1965631450C126322002 @default.
• W1965631450 hasConceptScore W1965631450C126838900 @default.
• W1965631450 hasConceptScore W1965631450C164705383 @default.
• W1965631450 hasConceptScore W1965631450C2776820930 @default.
• W1965631450 hasConceptScore W1965631450C2778213512 @default.
• W1965631450 hasConceptScore W1965631450C2778742706 @default.
• W1965631450 hasConceptScore W1965631450C2780309369 @default.
• W1965631450 hasConceptScore W1965631450C2908647359 @default.
• W1965631450 hasConceptScore W1965631450C2909917808 @default.
• W1965631450 hasConceptScore W1965631450C2994533308 @default.
• W1965631450 hasConceptScore W1965631450C71924100 @default.
• W1965631450 hasConceptScore W1965631450C99454951 @default.
• W1965631450 hasIssue "3" @default.
• W1965631450 hasLocation W19656314501 @default.
• W1965631450 hasLocation W19656314502 @default.
• W1965631450 hasOpenAccess W1965631450 @default.
• W1965631450 hasPrimaryLocation W19656314501 @default.
• W1965631450 hasRelatedWork W1989383463 @default.
• W1965631450 hasRelatedWork W2027281020 @default.
• W1965631450 hasRelatedWork W2354432962 @default.
• W1965631450 hasRelatedWork W2390088164 @default.
• W1965631450 hasRelatedWork W2392348384 @default.
• W1965631450 hasRelatedWork W2907724389 @default.
• W1965631450 hasRelatedWork W2912644616 @default.
• W1965631450 hasRelatedWork W3113925325 @default.
• W1965631450 hasRelatedWork W4289877802 @default.
• W1965631450 hasRelatedWork W4312994139 @default.
• W1965631450 hasVolume "3" @default.
• W1965631450 isParatext "false" @default.
• W1965631450 isRetracted "false" @default.
• W1965631450 magId "1965631450" @default.
• W1965631450 workType "article" @default.