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- W1965634326 abstract "Ixora parviflora with high polyphenol content exhibited antioxidant activity and reducing UVB-induced intracellular reactive oxygen species production. In this study, results of the photoaging screening experiments revealed that IPE at 1000 μ g/mL reduced the activity of bacterial collagenase by 92.7 ± 4.2% and reduced the activity of elastase by 32.6 ± 1.4%. Therefore, we investigated the mechanisms by which IPE exerts its anti-photoaging activity. IPE at 1 μ g/mL led to an increase in type I procollagen expression and increased total collagen synthesis in fibroblasts at 5 μ g/mL. We found that IPE inhibited MMP-1, MMP-3, and MMP-9 expression at doses of 1, 5, and 10 μ g/mL, respectively, in fibroblasts exposed to UV irradiation (40 mJ/cm 2 ). Gelatin zymography assay showed that IPE at 50 μ g/mL inhibited MMP-9 secretion/activity in cultured fibroblasts after UVB exposure. In addition, IPE inhibited the phosphorylation of p38, ERK, and JNK induced by UVB. Furthermore, IPE inhibited the UVB-induced expression of Smad7. In addition, IPE at 1 μ g/mL inhibited NO production and COX-2 expression in UV-exposed fibroblasts. These findings show that IPE exhibits anti-inflammatory and anti-photoaging activities, indicating that IPE could be a potential anti-aging agent." @default.
- W1965634326 created "2016-06-24" @default.
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- W1965634326 date "2012-01-01" @default.
- W1965634326 modified "2023-10-15" @default.
- W1965634326 title "<i>Ixora parviflora</i>Protects against UVB-Induced Photoaging by Inhibiting the Expression of MMPs, MAP Kinases, and COX-2 and by Promoting Type I Procollagen Synthesis" @default.
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- W1965634326 doi "https://doi.org/10.1155/2012/417346" @default.
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