Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965641574> ?p ?o ?g. }
- W1965641574 endingPage "1506" @default.
- W1965641574 startingPage "1495" @default.
- W1965641574 abstract "Hypothalamic neuropeptide Y (NPY) is an appetite stimulant in the brain. Although regulation of NPY expression has been reported to contribute to the appetite-suppressing effect of phenylpropanolamine (PPA), it is still unknown if protein kinase C (PKC) is involved in this effect. Rats were daily treated with PPA for 4 days. Changes in food intake, hypothalamic NPY, PKC, and proopiomelanocortin (POMC) mRNA levels were assessed and compared. Results showed that the NPY gene was down-regulated following PPA treatment, which was parallel with the decrease of feeding. Moreover, several isotypes of PKC mRNA level (α, βI, βII, γ, δ, η, λ, ε, and ζ) were changed. Among these, α, δ, and λ PKC were up-regulated along with POMC gene expression which coincided with down-regulation of the NPY gene. To further determine if PKCα was involved, infusions of antisense oligonucleotide into the cerebroventricle were performed at 1 h before daily PPA treatment in free-moving rats. Results showed that PKCα knock-down could modify both anorexia induced by PPA and the NPY mRNA levels. Moreover, PKCα knock-down could also modify superoxide dismutase (SOD) gene expression. It is suggested that PKCα participates in the regulation of PPA-mediated appetite suppression via the modulation of NPY and SOD gene expression." @default.
- W1965641574 created "2016-06-24" @default.
- W1965641574 creator A5001528957 @default.
- W1965641574 creator A5014260545 @default.
- W1965641574 creator A5014422191 @default.
- W1965641574 creator A5052063716 @default.
- W1965641574 creator A5062519695 @default.
- W1965641574 date "2009-03-01" @default.
- W1965641574 modified "2023-10-05" @default.
- W1965641574 title "Roles of protein kinase Cα isozyme in the regulation of oxidative stress and neuropeptide Y gene expression in phenylpropanolamine-mediated appetite suppression" @default.
- W1965641574 cites W1519193756 @default.
- W1965641574 cites W1698695320 @default.
- W1965641574 cites W1969856246 @default.
- W1965641574 cites W1972943445 @default.
- W1965641574 cites W1973295529 @default.
- W1965641574 cites W1975995627 @default.
- W1965641574 cites W1979325866 @default.
- W1965641574 cites W1981279705 @default.
- W1965641574 cites W1981731381 @default.
- W1965641574 cites W1985288054 @default.
- W1965641574 cites W1993282564 @default.
- W1965641574 cites W1995599027 @default.
- W1965641574 cites W1997763305 @default.
- W1965641574 cites W2001063528 @default.
- W1965641574 cites W2001885223 @default.
- W1965641574 cites W2006885743 @default.
- W1965641574 cites W2017245822 @default.
- W1965641574 cites W2020525682 @default.
- W1965641574 cites W2023402990 @default.
- W1965641574 cites W2025653842 @default.
- W1965641574 cites W2029262405 @default.
- W1965641574 cites W2040657222 @default.
- W1965641574 cites W2045179948 @default.
- W1965641574 cites W2046931788 @default.
- W1965641574 cites W2054351060 @default.
- W1965641574 cites W2058197089 @default.
- W1965641574 cites W2061093343 @default.
- W1965641574 cites W2063200179 @default.
- W1965641574 cites W2065139824 @default.
- W1965641574 cites W2075959393 @default.
- W1965641574 cites W2077749148 @default.
- W1965641574 cites W2080183386 @default.
- W1965641574 cites W2083432236 @default.
- W1965641574 cites W2083689697 @default.
- W1965641574 cites W2092554038 @default.
- W1965641574 cites W2101641963 @default.
- W1965641574 cites W2139732553 @default.
- W1965641574 cites W2139803804 @default.
- W1965641574 cites W2140607394 @default.
- W1965641574 cites W2141655765 @default.
- W1965641574 cites W2144593405 @default.
- W1965641574 cites W2146484653 @default.
- W1965641574 cites W2150833441 @default.
- W1965641574 cites W2153920502 @default.
- W1965641574 cites W2157936929 @default.
- W1965641574 cites W2159702499 @default.
- W1965641574 cites W2171515556 @default.
- W1965641574 cites W2313180533 @default.
- W1965641574 cites W4231924994 @default.
- W1965641574 cites W4294216491 @default.
- W1965641574 doi "https://doi.org/10.1111/j.1471-4159.2009.05909.x" @default.
- W1965641574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19183253" @default.
- W1965641574 hasPublicationYear "2009" @default.
- W1965641574 type Work @default.
- W1965641574 sameAs 1965641574 @default.
- W1965641574 citedByCount "9" @default.
- W1965641574 countsByYear W19656415742012 @default.
- W1965641574 countsByYear W19656415742013 @default.
- W1965641574 countsByYear W19656415742014 @default.
- W1965641574 crossrefType "journal-article" @default.
- W1965641574 hasAuthorship W1965641574A5001528957 @default.
- W1965641574 hasAuthorship W1965641574A5014260545 @default.
- W1965641574 hasAuthorship W1965641574A5014422191 @default.
- W1965641574 hasAuthorship W1965641574A5052063716 @default.
- W1965641574 hasAuthorship W1965641574A5062519695 @default.
- W1965641574 hasBestOaLocation W19656415741 @default.
- W1965641574 hasConcept C104317684 @default.
- W1965641574 hasConcept C118303440 @default.
- W1965641574 hasConcept C119795356 @default.
- W1965641574 hasConcept C126322002 @default.
- W1965641574 hasConcept C134018914 @default.
- W1965641574 hasConcept C150194340 @default.
- W1965641574 hasConcept C170493617 @default.
- W1965641574 hasConcept C181199279 @default.
- W1965641574 hasConcept C184235292 @default.
- W1965641574 hasConcept C185592680 @default.
- W1965641574 hasConcept C195794163 @default.
- W1965641574 hasConcept C2777003273 @default.
- W1965641574 hasConcept C2781309135 @default.
- W1965641574 hasConcept C2781399573 @default.
- W1965641574 hasConcept C55493867 @default.
- W1965641574 hasConcept C71924100 @default.
- W1965641574 hasConcept C75908981 @default.
- W1965641574 hasConcept C86803240 @default.
- W1965641574 hasConcept C93984277 @default.
- W1965641574 hasConcept C98274493 @default.
- W1965641574 hasConceptScore W1965641574C104317684 @default.
- W1965641574 hasConceptScore W1965641574C118303440 @default.