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- W1965651913 abstract "In an attempt to elucidate the mechanism of RNA formation from CβA and HU the relative incorporation of a number of derivatives was determined. From the data it is clear that the ribotides of CβA and HU are much superior to the parent compounds and to orotate or CO2 as precursors of RNA. The ribosides of CβA and HU were incorporated somewhat better than the parent compounds. To clarify the intermediate steps in the sequence, the appearance of [14C]CβA and [14C]HU into their ribotides was demonstrated. A reaction involving DPN and HURP to give URP was demonstrated and attempts to purify the system were made. Apparently, TPN and/or the flavins are not involved. Evidence for the cyclization of CARP to HURP was obtained with the suggestion that a more exergonic condition than simple reversal of hydrolysis is required." @default.
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- W1965651913 date "1959-01-01" @default.
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- W1965651913 title "Contribution of hydrouracil and its derivatives to pyrimidine biosynthesis II. Mechanism studies" @default.
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- W1965651913 doi "https://doi.org/10.1016/0006-3002(59)90244-6" @default.
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