FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965660329> ?p ?o ?g. }

• W1965660329 endingPage "2688" @default.
• W1965660329 startingPage "2678" @default.
• W1965660329 abstract "Activation of the Rho GTPase pathway determines endothelial cell (EC) hyperpermeability after injurious stimuli. To date, feedback mechanisms of Rho down-regulation critical for barrier restoration remain poorly understood. We tested a hypothesis that Rho down-regulation and barrier recovery of agonist-stimulated ECs is mediated by the Ras family GTPase Rap1. Thrombin-induced EC permeability driven by rapid activation of the Rho GTPase pathway was followed by Src kinase–dependent phosphorylation of the Rap1-specific guanine nucleotide exchange factor (GEF) C3G, activation of Rap1, and initiation of EC barrier recovery. Knockdown experiments showed that Rap1 activation was essential for down-regulation of Rho signaling and actin stress fiber dissolution. Rap1 activation also enhanced interaction between adherens junction (AJ) proteins VE-cadherin and p120-catenin and stimulated AJ reannealing mediated by the Rap1 effector afadin. This mechanism also included Rap1-dependent membrane translocation of the Rac1-specific GEF Tiam1 and activation of Rac1-dependent peripheral cytoskeletal dynamics, leading to resealing of intercellular gaps. These data demonstrate that activation of the Rap1-afadin axis is a physiological mechanism driving restoration of barrier integrity in agonist-stimulated EC monolayers via negative-feedback regulation of Rho signaling, stimulation of actin peripheral dynamics, and reestablishment of cell–cell adhesive complexes." @default.
• W1965660329 created "2016-06-24" @default.
• W1965660329 creator A5030184709 @default.
• W1965660329 creator A5046940174 @default.
• W1965660329 creator A5055642996 @default.
• W1965660329 creator A5072339257 @default.
• W1965660329 creator A5083620952 @default.
• W1965660329 date "2013-09-01" @default.
• W1965660329 modified "2023-09-26" @default.
• W1965660329 title "Rap-afadin axis in control of Rho signaling and endothelial barrier recovery" @default.
• W1965660329 cites W1905551819 @default.
• W1965660329 cites W1964171635 @default.
• W1965660329 cites W1969235425 @default.
• W1965660329 cites W1970170695 @default.
• W1965660329 cites W1972442140 @default.
• W1965660329 cites W1979027806 @default.
• W1965660329 cites W1980953487 @default.
• W1965660329 cites W1983790767 @default.
• W1965660329 cites W1984607094 @default.
• W1965660329 cites W1995757732 @default.
• W1965660329 cites W1996645283 @default.
• W1965660329 cites W2002122463 @default.
• W1965660329 cites W2008575015 @default.
• W1965660329 cites W2009080196 @default.
• W1965660329 cites W2011098845 @default.
• W1965660329 cites W2015174250 @default.
• W1965660329 cites W2016095963 @default.
• W1965660329 cites W2028000765 @default.
• W1965660329 cites W2029991360 @default.
• W1965660329 cites W2033830127 @default.
• W1965660329 cites W2040210675 @default.
• W1965660329 cites W2040880898 @default.
• W1965660329 cites W2040916665 @default.
• W1965660329 cites W2048580726 @default.
• W1965660329 cites W2057663938 @default.
• W1965660329 cites W2063716341 @default.
• W1965660329 cites W2064492584 @default.
• W1965660329 cites W2066464941 @default.
• W1965660329 cites W2077080652 @default.
• W1965660329 cites W2077298757 @default.
• W1965660329 cites W2079944376 @default.
• W1965660329 cites W2083063047 @default.
• W1965660329 cites W2084147384 @default.
• W1965660329 cites W2095397788 @default.
• W1965660329 cites W2103753682 @default.
• W1965660329 cites W2104527243 @default.
• W1965660329 cites W2105746559 @default.
• W1965660329 cites W2106435662 @default.
• W1965660329 cites W2110885875 @default.
• W1965660329 cites W2112281734 @default.
• W1965660329 cites W2119679162 @default.
• W1965660329 cites W2127744884 @default.
• W1965660329 cites W2128273788 @default.
• W1965660329 cites W2131206883 @default.
• W1965660329 cites W2132793070 @default.
• W1965660329 cites W2135749644 @default.
• W1965660329 cites W2144240811 @default.
• W1965660329 cites W2144323830 @default.
• W1965660329 cites W2149334247 @default.
• W1965660329 cites W2154785597 @default.
• W1965660329 cites W2162049443 @default.
• W1965660329 cites W2164227785 @default.
• W1965660329 cites W2167039432 @default.
• W1965660329 cites W2186734062 @default.
• W1965660329 doi "https://doi.org/10.1091/mbc.e13-02-0098" @default.
• W1965660329 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3756920" @default.
• W1965660329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23864716" @default.
• W1965660329 hasPublicationYear "2013" @default.
• W1965660329 type Work @default.
• W1965660329 sameAs 1965660329 @default.
• W1965660329 citedByCount "66" @default.
• W1965660329 countsByYear W19656603292013 @default.
• W1965660329 countsByYear W19656603292014 @default.
• W1965660329 countsByYear W19656603292015 @default.
• W1965660329 countsByYear W19656603292016 @default.
• W1965660329 countsByYear W19656603292017 @default.
• W1965660329 countsByYear W19656603292018 @default.
• W1965660329 countsByYear W19656603292019 @default.
• W1965660329 countsByYear W19656603292020 @default.
• W1965660329 countsByYear W19656603292021 @default.
• W1965660329 countsByYear W19656603292022 @default.
• W1965660329 countsByYear W19656603292023 @default.
• W1965660329 crossrefType "journal-article" @default.
• W1965660329 hasAuthorship W1965660329A5030184709 @default.
• W1965660329 hasAuthorship W1965660329A5046940174 @default.
• W1965660329 hasAuthorship W1965660329A5055642996 @default.
• W1965660329 hasAuthorship W1965660329A5072339257 @default.
• W1965660329 hasAuthorship W1965660329A5083620952 @default.
• W1965660329 hasBestOaLocation W19656603291 @default.
• W1965660329 hasConcept C125705527 @default.
• W1965660329 hasConcept C126619667 @default.
• W1965660329 hasConcept C142669718 @default.
• W1965660329 hasConcept C1491633281 @default.
• W1965660329 hasConcept C149402561 @default.
• W1965660329 hasConcept C151166631 @default.
• W1965660329 hasConcept C201508349 @default.
• W1965660329 hasConcept C207332259 @default.
• W1965660329 hasConcept C2776000893 @default.

• next