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- W1965661401 abstract "To the Editor: We read with considerable interest the paper by Danielski et al1Danielski M. Ikizler T.A. McMonagle E. et al.Linkage of hypoalbuminemia, inflammation, and oxidative stress in patients receiving maintenance hemodialysis therapy.Am J Kidney Dis. 2003; 42: 286-294Abstract Full Text Full Text PDF Scopus (145) Google Scholar concerning the role of oxidative stress and inflammation in hemodialysis patients. The authors clearly acknowledge the potential association between oxidative stress and inflammation in this setting. Oxidative stress appears to be a key component of many reactions associated with chronic inflammation in hemodialysis patients, as well as atherosclerosis in general.2Wratten M.L. Galaris D. Tetta C. Sevanian A. Evolution of oxidative stress and inflammation during hemodialysis and their contribution to cardiovascular disease.Antiox Redox Signal. 2002; 4: 935-944Google Scholar Theoretically, a significant reduction of oxidative stress, and subsequent inflammatory response, could possibly correct many of the pathologies of hemodialysis that lead to cardiovascular complications. On the other hand, in the light of recent evidence that C-reactive protein (CRP) strongly predicts all-cause mortality in these patients, it seems reasonable that amelioration of inflammation might lead to substantial clinical benefits.3Wanner C. Metzger T. C-reactive protein A marker for all-cause and cardiovascular mortality in haemodialysis patients .Nephrol Dial Transplant. 2002; 17: 29-32Google ScholarAccumulating evidence suggests that acute-phase reactants, mainly CRP, are related to oxidative stress markers such as F2-isoprostanes,1Danielski M. Ikizler T.A. McMonagle E. et al.Linkage of hypoalbuminemia, inflammation, and oxidative stress in patients receiving maintenance hemodialysis therapy.Am J Kidney Dis. 2003; 42: 286-294Abstract Full Text Full Text PDF Scopus (145) Google Scholar, 4Locatelli F. Canaud B. Eckardt K.U. Stenvinkel P. Wanner C. Zoccali C. Oxidative stress in end-stage renal disease An emerging threat to patient outcome .Nephrol Dial Transplant. 2003; 18: 1272-1280Google Scholar, 5Spittle M.A. Hoenich N.A. Handelman G.J. Adhikarla R. Homel P. Levin N.W. Oxidative stress and inflammation in hemodialysis patients.Am J Kidney Dis. 2001; 38: 1408-1413Google Scholar although a recent study reported negative results regarding this correlation.6Bayes B. Pastor M.C. Bonal J. et al.Homocysteine, C-reactive protein, lipid peroxidation and mortality in haemodialysis patients.Nephrol Dial Transplant. 2003; 18: 106-112Google Scholar In fact, the association of oxidative stress with CRP might be of great clinical importance, since easily determined markers of oxidative stress are lacking.7Korantzopoulos P. Papaioannides D. Galaris D. Kokkoris S. Does C-reactive protein represent an oxidative stress marker in cardiovascular disease?.Int J Clin Pract. 2003; 57: 252Google Scholar In other words, CRP may serve as an oxidative stress marker7Korantzopoulos P. Papaioannides D. Galaris D. Kokkoris S. Does C-reactive protein represent an oxidative stress marker in cardiovascular disease?.Int J Clin Pract. 2003; 57: 252Google Scholar; therefore, the effect of various antioxidant interventions could be efficiently assessed. Even though antioxidant interventions in hemodialysis patients have already been performed, their impact on inflammatory markers has not been studied yet. Hence, we believe that the complex interplay between oxidative stress and inflammation deserves further study. Whether specific antioxidant interventions can favorably affect inflammation and cardiovascular risk in these patients remains to be seen. To the Editor: We read with considerable interest the paper by Danielski et al1Danielski M. Ikizler T.A. McMonagle E. et al.Linkage of hypoalbuminemia, inflammation, and oxidative stress in patients receiving maintenance hemodialysis therapy.Am J Kidney Dis. 2003; 42: 286-294Abstract Full Text Full Text PDF Scopus (145) Google Scholar concerning the role of oxidative stress and inflammation in hemodialysis patients. The authors clearly acknowledge the potential association between oxidative stress and inflammation in this setting. Oxidative stress appears to be a key component of many reactions associated with chronic inflammation in hemodialysis patients, as well as atherosclerosis in general.2Wratten M.L. Galaris D. Tetta C. Sevanian A. Evolution of oxidative stress and inflammation during hemodialysis and their contribution to cardiovascular disease.Antiox Redox Signal. 2002; 4: 935-944Google Scholar Theoretically, a significant reduction of oxidative stress, and subsequent inflammatory response, could possibly correct many of the pathologies of hemodialysis that lead to cardiovascular complications. On the other hand, in the light of recent evidence that C-reactive protein (CRP) strongly predicts all-cause mortality in these patients, it seems reasonable that amelioration of inflammation might lead to substantial clinical benefits.3Wanner C. Metzger T. C-reactive protein A marker for all-cause and cardiovascular mortality in haemodialysis patients .Nephrol Dial Transplant. 2002; 17: 29-32Google Scholar Accumulating evidence suggests that acute-phase reactants, mainly CRP, are related to oxidative stress markers such as F2-isoprostanes,1Danielski M. Ikizler T.A. McMonagle E. et al.Linkage of hypoalbuminemia, inflammation, and oxidative stress in patients receiving maintenance hemodialysis therapy.Am J Kidney Dis. 2003; 42: 286-294Abstract Full Text Full Text PDF Scopus (145) Google Scholar, 4Locatelli F. Canaud B. Eckardt K.U. Stenvinkel P. Wanner C. Zoccali C. Oxidative stress in end-stage renal disease An emerging threat to patient outcome .Nephrol Dial Transplant. 2003; 18: 1272-1280Google Scholar, 5Spittle M.A. Hoenich N.A. Handelman G.J. Adhikarla R. Homel P. Levin N.W. Oxidative stress and inflammation in hemodialysis patients.Am J Kidney Dis. 2001; 38: 1408-1413Google Scholar although a recent study reported negative results regarding this correlation.6Bayes B. Pastor M.C. Bonal J. et al.Homocysteine, C-reactive protein, lipid peroxidation and mortality in haemodialysis patients.Nephrol Dial Transplant. 2003; 18: 106-112Google Scholar In fact, the association of oxidative stress with CRP might be of great clinical importance, since easily determined markers of oxidative stress are lacking.7Korantzopoulos P. Papaioannides D. Galaris D. Kokkoris S. Does C-reactive protein represent an oxidative stress marker in cardiovascular disease?.Int J Clin Pract. 2003; 57: 252Google Scholar In other words, CRP may serve as an oxidative stress marker7Korantzopoulos P. Papaioannides D. Galaris D. Kokkoris S. Does C-reactive protein represent an oxidative stress marker in cardiovascular disease?.Int J Clin Pract. 2003; 57: 252Google Scholar; therefore, the effect of various antioxidant interventions could be efficiently assessed. Even though antioxidant interventions in hemodialysis patients have already been performed, their impact on inflammatory markers has not been studied yet. Hence, we believe that the complex interplay between oxidative stress and inflammation deserves further study. Whether specific antioxidant interventions can favorably affect inflammation and cardiovascular risk in these patients remains to be seen." @default.
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- W1965661401 title "The association of oxidative stress and inflammation in hemodialysis patients" @default.
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