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• W1965676278 endingPage "5180" @default.
• W1965676278 startingPage "5171" @default.
• W1965676278 abstract "A novel biodegradable nanocomposite porous scaffold comprising a beta-tricalcium phosphate (beta-TCP) matrix and hydroxyl apatite (HA) nanofibers was developed and studied for load-bearing bone tissue engineering. HA nanofibers were prepared with a biomimetic precipitation method. The composite scaffolds were fabricated by a method combining the gel casting and polymer sponge techniques. The role of HA nanofibers in enhancing the mechanical properties of the scaffold was investigated. Compression tests were performed to measure the compressive strength, modulus and toughness of the porous scaffolds. The identification and morphology of HA nanofibers were determined by X-ray diffraction and transmission electron microscopy, respectively. Scanning electron microscopy was used to examine the morphology of porous scaffolds and fracture surfaces to reveal the dominant toughening mechanisms. The results showed that the mechanical property of the scaffold was significantly enhanced by the inclusion of HA nanofibers. The porous composite scaffold attained a compressive strength of 9.8 +/- 0.3 MPa, comparable to the high-end value (2-10 MPa) of cancellous bone. The toughness of the scaffold increased from 1.00+/-0.04 to 1.72+/-0.02 kN/m, as the concentration of HA nanofibers increased from 0 to 5 wt %." @default.
• W1965676278 created "2016-06-24" @default.
• W1965676278 creator A5023621385 @default.
• W1965676278 creator A5082164835 @default.
• W1965676278 date "2004-09-01" @default.
• W1965676278 modified "2023-10-10" @default.
• W1965676278 title "Biphasic calcium phosphate nanocomposite porous scaffolds for load-bearing bone tissue engineering" @default.
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• W1965676278 doi "https://doi.org/10.1016/j.biomaterials.2003.12.023" @default.
• W1965676278 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15109841" @default.
• W1965676278 hasPublicationYear "2004" @default.
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