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- W1965687452 abstract "Summary and ConclusionsIt appears from this study that Δ4 pregnen-in-20-on-3-ol-17 exhibits bisexual properties when administered subcutaneously in oil to immature, female rats, having an estrogen-like action on the uterus and vagina and an androgen-like action on the preputial glands and clitoris. The trophic effect on the genital tract appears to be a direct one and not mediated through the ovaries, as shown by the elicitation of similar effects in ovariec-tomized immature animals. Unlike testosterone, however, preg-neninolone appears not to have a stimulating effect upon the gonado-tropic activity of the hypophysis, as indicated by the absence of corpora lutea formation or evidence of follicle stimulation in the ovaries.It is interesting to note that this compound possesses a unique variety of biological properties. In addition to its progesterone-like action on the endometrium, Courrier and Jost14 have found that pregneninolone will maintain pregnancy in spayed rabbits and is androgenic in castrated r..." @default.
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- W1965687452 date "1940-04-01" @default.
- W1965687452 modified "2023-09-23" @default.
- W1965687452 title "Effect of Pregneninolone (17-Ethinyl Testosterone) on Genital Tract of Immature Female Rats" @default.
- W1965687452 doi "https://doi.org/10.3181/00379727-43-11311p" @default.
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