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• W1965699247 abstract "Acute kidney injury (AKI) is associated with high levels of mortality and an increased risk of progressive chronic kidney disease. Here, David Ferenbach and Joseph Bonventre describe the mechanisms involved in the initiation and propagation of AKI. They discuss the prototypic mechanisms employed by the damaged kidney to repair, and how the adaptive processes of repair can become maladaptive, leading to the development of progressive fibrotic kidney disease and a state that can be considered accelerated kidney ageing. Acute kidney injury is an increasingly common complication of hospital admission and is associated with high levels of morbidity and mortality. A hypotensive, septic, or toxic insult can initiate a cascade of events, resulting in impaired microcirculation, activation of inflammatory pathways and tubular cell injury or death. These processes ultimately result in acutely impaired kidney function and initiation of a repair response. This Review explores the various mechanisms responsible for the initiation and propagation of acute kidney injury, the prototypic mechanisms by which a substantially damaged kidney can regenerate its normal architecture, and how the adaptive processes of repair can become maladaptive. These mechanisms, which include G2/M cell-cycle arrest, cell senescence, profibrogenic cytokine production, and activation of pericytes and interstitial myofibroblasts, contribute to the development of progressive fibrotic kidney disease. The end result is a state that mimics accelerated kidney ageing. These mechanisms present important opportunities for the design of targeted therapeutic strategies to promote adaptive renal recovery and minimize progressive fibrosis and chronic kidney disease after acute insults." @default.
• W1965699247 created "2016-06-24" @default.
• W1965699247 creator A5030110805 @default.
• W1965699247 creator A5089781525 @default.
• W1965699247 date "2015-02-03" @default.
• W1965699247 modified "2023-10-09" @default.
• W1965699247 title "Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD" @default.
• W1965699247 cites W1548761095 @default.
• W1965699247 cites W1600560134 @default.
• W1965699247 cites W1894543987 @default.
• W1965699247 cites W1908580181 @default.
• W1965699247 cites W1964454505 @default.
• W1965699247 cites W1965059203 @default.
• W1965699247 cites W1965588383 @default.
• W1965699247 cites W1968632982 @default.
• W1965699247 cites W1969252550 @default.
• W1965699247 cites W1969905245 @default.
• W1965699247 cites W1970062316 @default.
• W1965699247 cites W1970377223 @default.
• W1965699247 cites W1970657176 @default.
• W1965699247 cites W1971799714 @default.
• W1965699247 cites W1973358829 @default.
• W1965699247 cites W1973597428 @default.
• W1965699247 cites W1973959559 @default.
• W1965699247 cites W1976996489 @default.
• W1965699247 cites W1978350136 @default.
• W1965699247 cites W1979138717 @default.
• W1965699247 cites W1979481511 @default.
• W1965699247 cites W1980224469 @default.
• W1965699247 cites W1982260752 @default.
• W1965699247 cites W1982628508 @default.
• W1965699247 cites W1982684746 @default.
• W1965699247 cites W1985457845 @default.
• W1965699247 cites W1986829962 @default.
• W1965699247 cites W1989205257 @default.
• W1965699247 cites W1991069902 @default.
• W1965699247 cites W1991997670 @default.
• W1965699247 cites W1993985512 @default.
• W1965699247 cites W1994304135 @default.
• W1965699247 cites W1994320316 @default.
• W1965699247 cites W1994390983 @default.
• W1965699247 cites W1994553956 @default.
• W1965699247 cites W1998226806 @default.
• W1965699247 cites W1999056245 @default.
• W1965699247 cites W1999668340 @default.
• W1965699247 cites W1999755139 @default.
• W1965699247 cites W2000811703 @default.
• W1965699247 cites W2004185848 @default.
• W1965699247 cites W2006828674 @default.
• W1965699247 cites W2008406050 @default.
• W1965699247 cites W2008947920 @default.
• W1965699247 cites W2011915481 @default.
• W1965699247 cites W2017089487 @default.
• W1965699247 cites W2018091219 @default.
• W1965699247 cites W2019888096 @default.
• W1965699247 cites W2020371427 @default.
• W1965699247 cites W2021017423 @default.
• W1965699247 cites W2021690806 @default.
• W1965699247 cites W2022360182 @default.
• W1965699247 cites W2022487205 @default.
• W1965699247 cites W2022737552 @default.
• W1965699247 cites W2023300193 @default.
• W1965699247 cites W2023848963 @default.
• W1965699247 cites W2023893179 @default.
• W1965699247 cites W2030705338 @default.
• W1965699247 cites W2031384622 @default.
• W1965699247 cites W2037376001 @default.
• W1965699247 cites W2039041903 @default.
• W1965699247 cites W2041926636 @default.
• W1965699247 cites W2041929136 @default.
• W1965699247 cites W2044341880 @default.
• W1965699247 cites W2045421375 @default.
• W1965699247 cites W2047856232 @default.
• W1965699247 cites W2049229230 @default.
• W1965699247 cites W2051032666 @default.
• W1965699247 cites W2052251011 @default.
• W1965699247 cites W2053402030 @default.
• W1965699247 cites W2054282870 @default.
• W1965699247 cites W2054525725 @default.
• W1965699247 cites W2056557856 @default.
• W1965699247 cites W2059422023 @default.
• W1965699247 cites W2059478642 @default.
• W1965699247 cites W2061687828 @default.
• W1965699247 cites W2065786649 @default.
• W1965699247 cites W2066362593 @default.
• W1965699247 cites W2066802700 @default.
• W1965699247 cites W2067709564 @default.
• W1965699247 cites W2068050227 @default.
• W1965699247 cites W2068287262 @default.
• W1965699247 cites W2069325081 @default.
• W1965699247 cites W2069519394 @default.
• W1965699247 cites W2069728361 @default.
• W1965699247 cites W2071183155 @default.
• W1965699247 cites W2073716079 @default.
• W1965699247 cites W2074733022 @default.
• W1965699247 cites W2075164296 @default.
• W1965699247 cites W2079079821 @default.
• W1965699247 cites W2079481850 @default.

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