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• W1965718088 abstract "Flap endonuclease 1 (FEN1) is a key enzyme in DNA repair and DNA replication. It is a structure-specific nuclease that removes 5'-overhanging flaps and the RNA/DNA primer during maturation of the Okazaki fragment. Homologues of FEN1 exist in a wide range of bacteria, archaea and eukaryotes. In order to further understand the structural basis of the DNA recognition, binding and cleavage mechanism of FEN1, the structure of FEN1 from the hyperthermophilic archaeon Desulfurococcus amylolyticus (DaFEN1) was determined at 2.00 Å resolution. The overall fold of DaFEN1 was similar to those of other archaeal FEN1 proteins; however, the helical clamp and the flexible loop exhibited a putative substrate-binding pocket with a unique conformation." @default.
• W1965718088 created "2016-06-24" @default.
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• W1965718088 date "2011-01-21" @default.
• W1965718088 modified "2023-09-30" @default.
• W1965718088 title "Structure of flap endonuclease 1 from the hyperthermophilic archaeon<i>Desulfurococcus amylolyticus</i>" @default.
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• W1965718088 doi "https://doi.org/10.1107/s1744309110053030" @default.
• W1965718088 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3034609" @default.
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• W1965718088 hasPublicationYear "2011" @default.
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