FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965718105> ?p ?o ?g. }

• W1965718105 endingPage "413" @default.
• W1965718105 startingPage "403" @default.
• W1965718105 abstract "Although apoptosis is considered one of the major mechanisms of CD4+ T cell depletion in HIV-infected patients, the virus-infected cells somehow appear to be protected from apoptosis, which generally occurs in bystander cells. Vpr is an auxiliary HIV-1 protein, which, unlike the other regulatory gene products, is present at high copy number in virus particles. We established stable transfectants of CD4+ T Jurkat cells constitutively expressing low levels of vpr. These clones exhibited cell cycle characteristics similar to those of control-transfected cells. Treatment of control clones with apoptotic stimuli (i.e., cycloheximide/tumor necrosis factor α (TNF-α), anti-Fas antibody, or serum starvation) resulted in a massive cell death by apoptosis. In contrast, all the vpr-expressing clones showed an impressive protection from apoptosis independently of the inducer. Notably, vpr antisense phosphorothioate oligodeoxynucleotides render vpr-expressing cells as susceptible to apoptosis induced by cycloheximide and TNF-α as the control clones. Moreover, the constitutive expression of HIV-1 vpr resulted in the upregulation of bcl-2, an oncogene endowed with antiapoptotic activities, and in the downmodulation of bax, a proapoptotic factor of the bcl-2 family. Altogether, these results suggest that low levels of the endogenous vpr protein can interfere with the physiological turnover of T lymphocytes at early stages of virus infection, thus facilitating HIV persistence and, subsequently, viral spread. This might explain why apoptosis mostly occurs in bystander uninfected cells in AIDS patients." @default.
• W1965718105 created "2016-06-24" @default.
• W1965718105 creator A5009678390 @default.
• W1965718105 creator A5012511355 @default.
• W1965718105 creator A5021070443 @default.
• W1965718105 creator A5030668753 @default.
• W1965718105 creator A5030856289 @default.
• W1965718105 creator A5041355970 @default.
• W1965718105 creator A5041689745 @default.
• W1965718105 creator A5057362417 @default.
• W1965718105 creator A5082781216 @default.
• W1965718105 creator A5091162026 @default.
• W1965718105 date "1998-02-02" @default.
• W1965718105 modified "2023-10-16" @default.
• W1965718105 title "The HIV-1 vpr Protein Acts as a Negative Regulator of Apoptosis in a Human Lymphoblastoid T Cell Line: Possible Implications for the Pathogenesis of AIDS" @default.
• W1965718105 cites W1480448067 @default.
• W1965718105 cites W1505545319 @default.
• W1965718105 cites W1552647437 @default.
• W1965718105 cites W1623819487 @default.
• W1965718105 cites W1625926039 @default.
• W1965718105 cites W1759299744 @default.
• W1965718105 cites W1807747199 @default.
• W1965718105 cites W1913681141 @default.
• W1965718105 cites W1925504181 @default.
• W1965718105 cites W1942163038 @default.
• W1965718105 cites W1954751611 @default.
• W1965718105 cites W1966700067 @default.
• W1965718105 cites W1970539759 @default.
• W1965718105 cites W1974393084 @default.
• W1965718105 cites W1974574099 @default.
• W1965718105 cites W1976038917 @default.
• W1965718105 cites W1979129905 @default.
• W1965718105 cites W1979478974 @default.
• W1965718105 cites W1983199063 @default.
• W1965718105 cites W1983747887 @default.
• W1965718105 cites W1994564363 @default.
• W1965718105 cites W1996091760 @default.
• W1965718105 cites W1997413979 @default.
• W1965718105 cites W1999614623 @default.
• W1965718105 cites W2001243226 @default.
• W1965718105 cites W2007150582 @default.
• W1965718105 cites W2010840723 @default.
• W1965718105 cites W2017708875 @default.
• W1965718105 cites W2021943787 @default.
• W1965718105 cites W2027073323 @default.
• W1965718105 cites W2047899422 @default.
• W1965718105 cites W2048133075 @default.
• W1965718105 cites W2048860241 @default.
• W1965718105 cites W2051320020 @default.
• W1965718105 cites W2060333964 @default.
• W1965718105 cites W2061525241 @default.
• W1965718105 cites W2061786750 @default.
• W1965718105 cites W2063287389 @default.
• W1965718105 cites W2072901265 @default.
• W1965718105 cites W2074192294 @default.
• W1965718105 cites W2078676274 @default.
• W1965718105 cites W2080022600 @default.
• W1965718105 cites W2081200884 @default.
• W1965718105 cites W2081911212 @default.
• W1965718105 cites W2085478334 @default.
• W1965718105 cites W2098625990 @default.
• W1965718105 cites W2100067355 @default.
• W1965718105 cites W2108779766 @default.
• W1965718105 cites W2116014786 @default.
• W1965718105 cites W2123750058 @default.
• W1965718105 cites W2125297918 @default.
• W1965718105 cites W2130200446 @default.
• W1965718105 cites W2134313753 @default.
• W1965718105 cites W2146187278 @default.
• W1965718105 cites W2150514496 @default.
• W1965718105 cites W2167922967 @default.
• W1965718105 cites W2265891106 @default.
• W1965718105 cites W2398721998 @default.
• W1965718105 cites W2414075451 @default.
• W1965718105 doi "https://doi.org/10.1084/jem.187.3.403" @default.
• W1965718105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2212119" @default.
• W1965718105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9449720" @default.
• W1965718105 hasPublicationYear "1998" @default.
• W1965718105 type Work @default.
• W1965718105 sameAs 1965718105 @default.
• W1965718105 citedByCount "131" @default.
• W1965718105 countsByYear W19657181052012 @default.
• W1965718105 countsByYear W19657181052013 @default.
• W1965718105 countsByYear W19657181052015 @default.
• W1965718105 countsByYear W19657181052017 @default.
• W1965718105 countsByYear W19657181052018 @default.
• W1965718105 countsByYear W19657181052019 @default.
• W1965718105 countsByYear W19657181052020 @default.
• W1965718105 countsByYear W19657181052021 @default.
• W1965718105 countsByYear W19657181052022 @default.
• W1965718105 crossrefType "journal-article" @default.
• W1965718105 hasAuthorship W1965718105A5009678390 @default.
• W1965718105 hasAuthorship W1965718105A5012511355 @default.
• W1965718105 hasAuthorship W1965718105A5021070443 @default.
• W1965718105 hasAuthorship W1965718105A5030668753 @default.
• W1965718105 hasAuthorship W1965718105A5030856289 @default.
• W1965718105 hasAuthorship W1965718105A5041355970 @default.
• W1965718105 hasAuthorship W1965718105A5041689745 @default.

• next