FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965718349> ?p ?o ?g. }

• W1965718349 endingPage "1488" @default.
• W1965718349 startingPage "1479" @default.
• W1965718349 abstract "Migrating cells can sustain a relatively constant direction of lamellipodial protrusion and locomotion over timescales ranging from minutes to hours. However, individual waves of lamellipodial extension occur over much shorter characteristic times. Little understanding exists regarding how cells might integrate biophysical processes across these disparate timescales to control the directional persistence of locomotion. We address this issue by examining the effects of epidermal growth factor (EGF) stimulation on long-timescale directional persistence and short-timescale lamellipodial dynamics of EGF receptor-transfected Chinese hamster ovary cells migrating on fibronectin-coated substrata. Addition of EGF increased persistence, with the magnitude of increase correlating with fibronectin coating concentration. Kymographic analysis of EGF-stimulated lamellipodial dynamics revealed that the temporal stability of lamellipodial protrusions similarly increased with fibronectin concentration. A soluble RGD peptide competitor reduced both the persistence of long-timescale cell paths and the stability of short-timescale membrane protrusions, indicating that cell-substratum adhesion concomitantly influences lamellipodial dynamics and directional persistence. These results reveal the importance of adhesion strength in regulating the directional motility of cells and suggest that the short-timescale kinetics of adhesion complex formation may play a key role in modulating directional persistence over much longer timescales." @default.
• W1965718349 created "2016-06-24" @default.
• W1965718349 creator A5015443816 @default.
• W1965718349 creator A5033761148 @default.
• W1965718349 creator A5036523877 @default.
• W1965718349 creator A5060106170 @default.
• W1965718349 date "2005-02-01" @default.
• W1965718349 modified "2023-10-12" @default.
• W1965718349 title "Directional Persistence of EGF-Induced Cell Migration Is Associated with Stabilization of Lamellipodial Protrusions" @default.
• W1965718349 cites W1604088022 @default.
• W1965718349 cites W179937664 @default.
• W1965718349 cites W1910650341 @default.
• W1965718349 cites W1967265143 @default.
• W1965718349 cites W1969753756 @default.
• W1965718349 cites W1969754919 @default.
• W1965718349 cites W1969781490 @default.
• W1965718349 cites W1970979847 @default.
• W1965718349 cites W1983838379 @default.
• W1965718349 cites W1983878009 @default.
• W1965718349 cites W1989021197 @default.
• W1965718349 cites W1990164386 @default.
• W1965718349 cites W1993199560 @default.
• W1965718349 cites W1993312924 @default.
• W1965718349 cites W2010632072 @default.
• W1965718349 cites W2012874302 @default.
• W1965718349 cites W2023054504 @default.
• W1965718349 cites W2032504743 @default.
• W1965718349 cites W2035912195 @default.
• W1965718349 cites W2036145275 @default.
• W1965718349 cites W2043911313 @default.
• W1965718349 cites W2048609835 @default.
• W1965718349 cites W2053431375 @default.
• W1965718349 cites W2055798867 @default.
• W1965718349 cites W2056563854 @default.
• W1965718349 cites W2060043235 @default.
• W1965718349 cites W2061680971 @default.
• W1965718349 cites W2066108081 @default.
• W1965718349 cites W2066655424 @default.
• W1965718349 cites W2067635861 @default.
• W1965718349 cites W2068092779 @default.
• W1965718349 cites W2070995184 @default.
• W1965718349 cites W2073891485 @default.
• W1965718349 cites W2080289648 @default.
• W1965718349 cites W2083963458 @default.
• W1965718349 cites W2089323578 @default.
• W1965718349 cites W2091555830 @default.
• W1965718349 cites W2092191773 @default.
• W1965718349 cites W2093288486 @default.
• W1965718349 cites W2093770224 @default.
• W1965718349 cites W2097672376 @default.
• W1965718349 cites W2098414179 @default.
• W1965718349 cites W2099158550 @default.
• W1965718349 cites W2099253537 @default.
• W1965718349 cites W2099322968 @default.
• W1965718349 cites W2105848821 @default.
• W1965718349 cites W2110981204 @default.
• W1965718349 cites W2129968928 @default.
• W1965718349 cites W2136989953 @default.
• W1965718349 cites W2138231208 @default.
• W1965718349 cites W2158973316 @default.
• W1965718349 cites W2167158173 @default.
• W1965718349 cites W2167956058 @default.
• W1965718349 cites W2409220685 @default.
• W1965718349 doi "https://doi.org/10.1529/biophysj.104.047365" @default.
• W1965718349 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1305149" @default.
• W1965718349 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15713602" @default.
• W1965718349 hasPublicationYear "2005" @default.
• W1965718349 type Work @default.
• W1965718349 sameAs 1965718349 @default.
• W1965718349 citedByCount "114" @default.
• W1965718349 countsByYear W19657183492012 @default.
• W1965718349 countsByYear W19657183492013 @default.
• W1965718349 countsByYear W19657183492014 @default.
• W1965718349 countsByYear W19657183492015 @default.
• W1965718349 countsByYear W19657183492016 @default.
• W1965718349 countsByYear W19657183492017 @default.
• W1965718349 countsByYear W19657183492018 @default.
• W1965718349 countsByYear W19657183492019 @default.
• W1965718349 countsByYear W19657183492020 @default.
• W1965718349 countsByYear W19657183492021 @default.
• W1965718349 countsByYear W19657183492022 @default.
• W1965718349 countsByYear W19657183492023 @default.
• W1965718349 crossrefType "journal-article" @default.
• W1965718349 hasAuthorship W1965718349A5015443816 @default.
• W1965718349 hasAuthorship W1965718349A5033761148 @default.
• W1965718349 hasAuthorship W1965718349A5036523877 @default.
• W1965718349 hasAuthorship W1965718349A5060106170 @default.
• W1965718349 hasBestOaLocation W19657183491 @default.
• W1965718349 hasConcept C12554922 @default.
• W1965718349 hasConcept C125705527 @default.
• W1965718349 hasConcept C127313418 @default.
• W1965718349 hasConcept C135903288 @default.
• W1965718349 hasConcept C137738243 @default.
• W1965718349 hasConcept C1491633281 @default.
• W1965718349 hasConcept C170493617 @default.
• W1965718349 hasConcept C178790620 @default.
• W1965718349 hasConcept C185592680 @default.
• W1965718349 hasConcept C187320778 @default.

• next