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• W1965718556 endingPage "18" @default.
• W1965718556 startingPage "12" @default.
• W1965718556 abstract "Contamination of water by cyanobacteria (blue–green algae) is a serious health problem around the world, largely due to the toxic effects of microcystins, a group of potent hepatotoxins. However, the mechanisms responsible for the cytotoxicity of microcystins have not been fully elucidated. In the present study, oxidative damage caused by lyophilized freshwater cyanobacteria extract was evaluated on primary cultured rat hepatocytes. A time- and dose-dependent increase of lactate dehydrogenase (LDH) leakage was observed in hepatocytes treated with cyanobacteria extract. Lipid peroxidation, a main manifestation of oxidative damage, was also studied and a time- and dose-dependent increase in malondiadehyde was observed. In addition, by using a fluorescent probe, 2′,7′-dichlorofluorescein diacetate, it was found that cyanobacteria extract was able to enhance intracellular production of reactive oxygen species (ROS) in a dose- and time-dependent manner. Moreover, desferrioxamine, a specific iron chelator, could significantly decrease LDH leakage and ROS production caused by cyanobacteria extract treatment. These findings thus provide experimental evidence that oxidative damage is involved in cyanobacteria extract-induced hepatotoxicity. The understanding of this mechanism is believed to be beneficial to the prevention and control of the toxicity of microcystin and cyanobacteria contamination." @default.
• W1965718556 created "2016-06-24" @default.
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• W1965718556 date "1998-07-01" @default.
• W1965718556 modified "2023-10-17" @default.
• W1965718556 title "Studies on Oxidative Damage Induced by Cyanobacteria Extract in Primary Cultured Rat Hepatocytes" @default.
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• W1965718556 doi "https://doi.org/10.1006/enrs.1998.3843" @default.
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• W1965718556 hasPublicationYear "1998" @default.
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