FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965718603> ?p ?o ?g. }

• W1965718603 endingPage "178" @default.
• W1965718603 startingPage "173" @default.
• W1965718603 abstract "DNA ligase IV (LIG4) and XRCC4 form a complex to ligate two DNA ends at the final step of DNA double-strand break (DSB) repair through non-homologous end-joining (NHEJ). It is not fully understood how these proteins are recruited to DSBs. We recently demonstrated radiation-induced chromatin binding of XRCC4 by biochemical fractionation using detergent Nonidet P-40. In the present study, we examined the role of LIG4 in the recruitment of XRCC4/LIG4 complex to chromatin. The chromatin binding of XRCC4 was dependent on the presence of LIG4. The mutations in two BRCT domains (W725R and W893R, respectively) of LIG4 reduced the chromatin binding of LIG4 and XRCC4. The C-terminal fragment of LIG4 (LIG4-CT) without N-terminal catalytic domains could bind to chromatin with XRCC4. LIG4-CT with W725R or W893R mutation could bind to chromatin but could not support the chromatin binding of XRCC4. The ability of C-terminal region of LIG4 to interact with chromatin might provide us with an insight into the mechanisms of DSB repair through NHEJ." @default.
• W1965718603 created "2016-06-24" @default.
• W1965718603 creator A5003962079 @default.
• W1965718603 creator A5016106257 @default.
• W1965718603 creator A5019366369 @default.
• W1965718603 creator A5037555363 @default.
• W1965718603 creator A5045855449 @default.
• W1965718603 creator A5049514406 @default.
• W1965718603 creator A5071888724 @default.
• W1965718603 date "2013-09-01" @default.
• W1965718603 modified "2023-10-03" @default.
• W1965718603 title "C-terminal region of DNA ligase IV drives XRCC4/DNA ligase IV complex to chromatin" @default.
• W1965718603 cites W1532833901 @default.
• W1965718603 cites W1861478519 @default.
• W1965718603 cites W1963613246 @default.
• W1965718603 cites W1964171776 @default.
• W1965718603 cites W1976336745 @default.
• W1965718603 cites W1978790850 @default.
• W1965718603 cites W1985643620 @default.
• W1965718603 cites W1988268809 @default.
• W1965718603 cites W1996271528 @default.
• W1965718603 cites W2013580891 @default.
• W1965718603 cites W2016949180 @default.
• W1965718603 cites W2024131694 @default.
• W1965718603 cites W2038260399 @default.
• W1965718603 cites W2049123604 @default.
• W1965718603 cites W2059493608 @default.
• W1965718603 cites W2060001445 @default.
• W1965718603 cites W2070369325 @default.
• W1965718603 cites W2071206740 @default.
• W1965718603 cites W2074141956 @default.
• W1965718603 cites W2075351905 @default.
• W1965718603 cites W2079891276 @default.
• W1965718603 cites W2083326500 @default.
• W1965718603 cites W2084919692 @default.
• W1965718603 cites W2088474558 @default.
• W1965718603 cites W2092920840 @default.
• W1965718603 cites W2094471445 @default.
• W1965718603 cites W2102329938 @default.
• W1965718603 cites W2116050965 @default.
• W1965718603 cites W2131235503 @default.
• W1965718603 cites W2135735491 @default.
• W1965718603 cites W2137239016 @default.
• W1965718603 cites W2141431181 @default.
• W1965718603 cites W2147348417 @default.
• W1965718603 cites W2161115929 @default.
• W1965718603 doi "https://doi.org/10.1016/j.bbrc.2013.08.068" @default.
• W1965718603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23994631" @default.
• W1965718603 hasPublicationYear "2013" @default.
• W1965718603 type Work @default.
• W1965718603 sameAs 1965718603 @default.
• W1965718603 citedByCount "11" @default.
• W1965718603 countsByYear W19657186032014 @default.
• W1965718603 countsByYear W19657186032015 @default.
• W1965718603 countsByYear W19657186032017 @default.
• W1965718603 countsByYear W19657186032018 @default.
• W1965718603 crossrefType "journal-article" @default.
• W1965718603 hasAuthorship W1965718603A5003962079 @default.
• W1965718603 hasAuthorship W1965718603A5016106257 @default.
• W1965718603 hasAuthorship W1965718603A5019366369 @default.
• W1965718603 hasAuthorship W1965718603A5037555363 @default.
• W1965718603 hasAuthorship W1965718603A5045855449 @default.
• W1965718603 hasAuthorship W1965718603A5049514406 @default.
• W1965718603 hasAuthorship W1965718603A5071888724 @default.
• W1965718603 hasConcept C104317684 @default.
• W1965718603 hasConcept C134459356 @default.
• W1965718603 hasConcept C134935766 @default.
• W1965718603 hasConcept C145803527 @default.
• W1965718603 hasConcept C153911025 @default.
• W1965718603 hasConcept C175114707 @default.
• W1965718603 hasConcept C25602115 @default.
• W1965718603 hasConcept C552990157 @default.
• W1965718603 hasConcept C55493867 @default.
• W1965718603 hasConcept C60748783 @default.
• W1965718603 hasConcept C83640560 @default.
• W1965718603 hasConcept C86803240 @default.
• W1965718603 hasConcept C95444343 @default.
• W1965718603 hasConceptScore W1965718603C104317684 @default.
• W1965718603 hasConceptScore W1965718603C134459356 @default.
• W1965718603 hasConceptScore W1965718603C134935766 @default.
• W1965718603 hasConceptScore W1965718603C145803527 @default.
• W1965718603 hasConceptScore W1965718603C153911025 @default.
• W1965718603 hasConceptScore W1965718603C175114707 @default.
• W1965718603 hasConceptScore W1965718603C25602115 @default.
• W1965718603 hasConceptScore W1965718603C552990157 @default.
• W1965718603 hasConceptScore W1965718603C55493867 @default.
• W1965718603 hasConceptScore W1965718603C60748783 @default.
• W1965718603 hasConceptScore W1965718603C83640560 @default.
• W1965718603 hasConceptScore W1965718603C86803240 @default.
• W1965718603 hasConceptScore W1965718603C95444343 @default.
• W1965718603 hasFunder F4320320912 @default.
• W1965718603 hasIssue "2" @default.
• W1965718603 hasLocation W19657186031 @default.
• W1965718603 hasLocation W19657186032 @default.
• W1965718603 hasOpenAccess W1965718603 @default.
• W1965718603 hasPrimaryLocation W19657186031 @default.
• W1965718603 hasRelatedWork W1660787335 @default.
• W1965718603 hasRelatedWork W1965718603 @default.

• next