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• W1965726386 abstract "The calcium-dependent adhesion molecules N- and R-cadherins take part in the morphogenesis of the nervous system. The data about their localization in the peripheral nerves postnatum are limited and somewhat controversial. In the present study, a new methodological approach to the immunohistochemical cadherin detection has been applied. The sciatic nerves of 10-day-old rats were immunotested on semi-thin Epon sections by anti-N- and R-cadherins polyclonal antibody and visualized by IgG conjugated to colloidal gold and silver amplification. In the myelinated nerve fibers, an immuno-like activity was associated with the axoplasm and axolemma, the surface of the myelinating Schwann cells and their extracellular matrix. The units of nonmyelinated fibres and their associated glial cells were also intensely immunostained. The myelin sheaths and the glial cytoplasm were immunonegative. The significance of the localization is discussed in regard to the possible role of N- and R-cadherins in the anatomical and functional compartmentation of peripheral nerves." @default.
• W1965726386 created "2016-06-24" @default.
• W1965726386 creator A5027018281 @default.
• W1965726386 creator A5029312907 @default.
• W1965726386 creator A5077427849 @default.
• W1965726386 date "2001-09-01" @default.
• W1965726386 modified "2023-09-27" @default.
• W1965726386 title "N- and R-cadherins expression in the rat sciatic nerve demonstrated by postembedding immunogold method on semi-thin sections" @default.
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• W1965726386 doi "https://doi.org/10.1016/s0940-9602(01)80193-x" @default.
• W1965726386 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11677806" @default.
• W1965726386 hasPublicationYear "2001" @default.
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