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• W1965730282 abstract "Increased or decreased hepatic lipase (HL) activity has been associated with coronary artery disease (CAD). This is consistent with the findings that gene variants that influence HL activity were associated with increased CAD risk in some population studies but not in others. In this review, we will explain the conditions that influence the effects of HL on CAD. Increased HL is associated with smaller and denser LDL (sdLDL) and HDL (HDL3) particles, while decreased HL is associated with larger and more buoyant LDL and HDL particles. The effect of HL activity on CAD risk is dependent on the underlying lipoprotein phenotype or disorder. Central obesity with hypertriglyceridemia (HTG) is associated with high HL activity that leads to the formation of sdLDL that is pro-atherogenic. In the absence of HTG, where large buoyant cholesteryl ester-enriched LDL is prominent, elevation of HL does not raise the risk for CAD. In HTG patients, drug therapy that decreases HL activity selectively decreases sdLDL particles, an anti-atherogenic effect. Drug therapy that raises HDL2 cholesterol has not decreased the risk for CAD. In trials where inhibition of cholesterol ester transfer protein (CETP) or HL occurs, the increase in HDL2 most likely is due to inhibition of catabolism of HDL2 and impairment of reverse cholesterol transport (RCT). In patients with isolated hypercholesterolemia, but with normal triglyceride levels and big-buoyant LDL particles, an increase in HL activity is beneficial; possibly because it increases RCT. Drugs that lower HL activity might decrease the risk for CAD only in hypertriglyceridemic patients with sdLDL by selectively clearing sdLDL particles from plasma, which would override the potentially pro-atherogenic effect on RCT. This article is part of a Special Issue entitled Advances in High Density Lipoprotein Formation and Metabolism: A Tribute to John F. Oram (1945–2010)." @default.
• W1965730282 created "2016-06-24" @default.
• W1965730282 creator A5039991924 @default.
• W1965730282 creator A5076756862 @default.
• W1965730282 creator A5082757276 @default.
• W1965730282 date "2012-03-01" @default.
• W1965730282 modified "2023-09-26" @default.
• W1965730282 title "The effect of hepatic lipase on coronary artery disease in humans is influenced by the underlying lipoprotein phenotype" @default.
• W1965730282 cites W1721811405 @default.
• W1965730282 cites W1859162852 @default.
• W1965730282 cites W1893505981 @default.
• W1965730282 cites W1945042007 @default.
• W1965730282 cites W1966628044 @default.
• W1965730282 cites W1966820548 @default.
• W1965730282 cites W1969070167 @default.
• W1965730282 cites W1969427823 @default.
• W1965730282 cites W1981670728 @default.
• W1965730282 cites W1983741676 @default.
• W1965730282 cites W1991251155 @default.
• W1965730282 cites W1991576489 @default.
• W1965730282 cites W1999551921 @default.
• W1965730282 cites W2002584924 @default.
• W1965730282 cites W2004823906 @default.
• W1965730282 cites W2012272510 @default.
• W1965730282 cites W2019863077 @default.
• W1965730282 cites W2029115254 @default.
• W1965730282 cites W2031070957 @default.
• W1965730282 cites W2034252035 @default.
• W1965730282 cites W2034881859 @default.
• W1965730282 cites W2035365435 @default.
• W1965730282 cites W2039479403 @default.
• W1965730282 cites W2042631829 @default.
• W1965730282 cites W2043847224 @default.
• W1965730282 cites W2045113865 @default.
• W1965730282 cites W2045353633 @default.
• W1965730282 cites W2045997860 @default.
• W1965730282 cites W2046991199 @default.
• W1965730282 cites W2048760408 @default.
• W1965730282 cites W2050856591 @default.
• W1965730282 cites W2052765319 @default.
• W1965730282 cites W2057821480 @default.
• W1965730282 cites W2063678266 @default.
• W1965730282 cites W2069210540 @default.
• W1965730282 cites W2071143966 @default.
• W1965730282 cites W2075367810 @default.
• W1965730282 cites W2075422170 @default.
• W1965730282 cites W2077942032 @default.
• W1965730282 cites W2080036080 @default.
• W1965730282 cites W2091126023 @default.
• W1965730282 cites W2095920347 @default.
• W1965730282 cites W2101414627 @default.
• W1965730282 cites W2101573428 @default.
• W1965730282 cites W2102979586 @default.
• W1965730282 cites W2103094551 @default.
• W1965730282 cites W2108475045 @default.
• W1965730282 cites W2110437194 @default.
• W1965730282 cites W2112848098 @default.
• W1965730282 cites W2114989554 @default.
• W1965730282 cites W2115801316 @default.
• W1965730282 cites W2127367710 @default.
• W1965730282 cites W2128709367 @default.
• W1965730282 cites W2128832145 @default.
• W1965730282 cites W2130189155 @default.
• W1965730282 cites W2130650926 @default.
• W1965730282 cites W2131491353 @default.
• W1965730282 cites W2134668632 @default.
• W1965730282 cites W2140479040 @default.
• W1965730282 cites W2143359916 @default.
• W1965730282 cites W2146720277 @default.
• W1965730282 cites W2149432688 @default.
• W1965730282 cites W2150172449 @default.
• W1965730282 cites W2150487049 @default.
• W1965730282 cites W2152086330 @default.
• W1965730282 cites W2155121555 @default.
• W1965730282 cites W2161527180 @default.
• W1965730282 cites W2162259781 @default.
• W1965730282 cites W2163802092 @default.
• W1965730282 cites W2164216188 @default.
• W1965730282 cites W2167121458 @default.
• W1965730282 cites W2169466388 @default.
• W1965730282 cites W2170397513 @default.
• W1965730282 cites W2291505933 @default.
• W1965730282 cites W2324712847 @default.
• W1965730282 cites W2347117299 @default.
• W1965730282 cites W4232807629 @default.
• W1965730282 cites W4236845029 @default.
• W1965730282 cites W4240273323 @default.
• W1965730282 cites W4241422218 @default.
• W1965730282 cites W4248443489 @default.
• W1965730282 cites W54812017 @default.
• W1965730282 doi "https://doi.org/10.1016/j.bbalip.2011.09.008" @default.
• W1965730282 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3288605" @default.
• W1965730282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21986251" @default.
• W1965730282 hasPublicationYear "2012" @default.
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