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• W1965734739 abstract "The present study reports the isolation of three complementary DNA (cDNA) clones encoding distinct subtypes of CRF receptors from the diploid catfish (cf) species, Ameiurus nebulosus. The first clone encodes a 446-amino acid protein (cfCRF-R1) that is highly homologous to mouse (m) CRF-R1 (93% identical). The cfCRF-R1 messenger RNA is highly expressed in the brain, and its distribution pattern correlates well with that of mammalian CRF-R1, except for weak expression in the pituitary. When transiently expressed in COS-7 cells, cfCRF-R1 bound CRF, urotensin I, and sauvagine with similar affinities. The second full-length cDNA, which was cloned from catfish heart, encodes a 406-amino acid protein that showed homology to murine CRF-R2 (88%) and when expressed in COS-7 cells preferentially bound sauvagine. The highest level of cfCRF-R2 expression was observed in the heart. The third full-length cDNA clone, which encodes a 428-amino acid protein, is structurally closer to cfCRF-R1 (85%) than to cfCRF-R2 (80%). This novel CRF receptor (cfCRF-R3) bound CRF with a 5-fold higher affinity than urotensin I and sauvagine and was expressed in the pituitary gland, urophysis, and brain. The presence of three different CRF receptors, each with distinct tissue distribution and ligand binding properties, suggests a complex CRF/urotensin I system." @default.
• W1965734739 created "2016-06-24" @default.
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• W1965734739 creator A5045869496 @default.
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• W1965734739 date "2001-01-01" @default.
• W1965734739 modified "2023-10-04" @default.
• W1965734739 title "Characterization of Three Corticotropin-Releasing Factor Receptors in Catfish: A Novel Third Receptor Is Predominantly Expressed in Pituitary and Urophysis*†*The nucleotide sequences reported in this paper have been submitted to the GenBank database with accession numbers cfCRF-R1, AF229359; cfCRF-R2, AF229360; and cfCRF-R3, AF229361.†This work was supported by NIDDK Grant 45020–04A1 from the NIH." @default.
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• W1965734739 doi "https://doi.org/10.1210/endo.142.1.7879" @default.
• W1965734739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11145609" @default.
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