Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965735440> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1965735440 endingPage "20" @default.
- W1965735440 startingPage "15" @default.
- W1965735440 abstract "<h2>Abstract</h2> In patients with chronic cardiac failure, improvement in ventricular function is observed after the administration of enoximone, a phosphodiesterase inhibitor with inotropic and vasodilator properties. The relative contributions of positive inotropy and vasodilation to the improvement in pump performance, however, remain uncertain. Therefore, findings from a series of dog experiments designed to resolve this issue are reviewed. Also, our current understanding of the physiologic response to enoximone in patients with cardiac failure, including the responses of myocardial oxygen consumption and efficiency, are considered. It is concluded that, enoximone produces a substantial (66 ± 2% in dogs) increase in contractility, a relatively minor increase in heart rate (0 to 12%) and a decrease in systemic vascular resistance (−28 to −49%). These are the ranges of average responses based on review of published findings. These physiologic responses lead to an improvement in the pumping function of the failing heart; cardiac output (23 to 83%) and stroke work index (17 to 88%) are increased, and pulmonary capillary wedge pressure (−19 to −59%) and right atrial pressure (−29 to −60%) are decreased. The influence of enoximone on myocardial oxygen consumption is less consistent (−18 to +33%). Nevertheless, enoximone improves the efficiency of the failing heart." @default.
- W1965735440 created "2016-06-24" @default.
- W1965735440 creator A5018410389 @default.
- W1965735440 creator A5054937974 @default.
- W1965735440 creator A5062981450 @default.
- W1965735440 date "1987-08-01" @default.
- W1965735440 modified "2023-09-24" @default.
- W1965735440 title "Physiologic response to the inotropic and vasodilator properties of enoximone" @default.
- W1965735440 cites W181049634 @default.
- W1965735440 cites W1970205478 @default.
- W1965735440 cites W1972918094 @default.
- W1965735440 cites W1973163757 @default.
- W1965735440 cites W1989524686 @default.
- W1965735440 cites W1996450444 @default.
- W1965735440 cites W2003999298 @default.
- W1965735440 cites W2005611290 @default.
- W1965735440 cites W2012273576 @default.
- W1965735440 cites W2024386613 @default.
- W1965735440 cites W2035377210 @default.
- W1965735440 cites W2039943805 @default.
- W1965735440 cites W2055872444 @default.
- W1965735440 cites W2062252786 @default.
- W1965735440 cites W2075876428 @default.
- W1965735440 cites W2076723747 @default.
- W1965735440 cites W2077417808 @default.
- W1965735440 cites W2083847661 @default.
- W1965735440 cites W2086342360 @default.
- W1965735440 cites W2119229486 @default.
- W1965735440 cites W2145950740 @default.
- W1965735440 cites W2172332868 @default.
- W1965735440 cites W2234131177 @default.
- W1965735440 cites W2279247657 @default.
- W1965735440 cites W2337579201 @default.
- W1965735440 cites W2439939196 @default.
- W1965735440 doi "https://doi.org/10.1016/0002-9149(87)90519-4" @default.
- W1965735440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2956862" @default.
- W1965735440 hasPublicationYear "1987" @default.
- W1965735440 type Work @default.
- W1965735440 sameAs 1965735440 @default.
- W1965735440 citedByCount "23" @default.
- W1965735440 crossrefType "journal-article" @default.
- W1965735440 hasAuthorship W1965735440A5018410389 @default.
- W1965735440 hasAuthorship W1965735440A5054937974 @default.
- W1965735440 hasAuthorship W1965735440A5062981450 @default.
- W1965735440 hasConcept C120770815 @default.
- W1965735440 hasConcept C126322002 @default.
- W1965735440 hasConcept C139940330 @default.
- W1965735440 hasConcept C146556889 @default.
- W1965735440 hasConcept C155710745 @default.
- W1965735440 hasConcept C164705383 @default.
- W1965735440 hasConcept C178853913 @default.
- W1965735440 hasConcept C2778198053 @default.
- W1965735440 hasConcept C2780529135 @default.
- W1965735440 hasConcept C39133596 @default.
- W1965735440 hasConcept C71924100 @default.
- W1965735440 hasConceptScore W1965735440C120770815 @default.
- W1965735440 hasConceptScore W1965735440C126322002 @default.
- W1965735440 hasConceptScore W1965735440C139940330 @default.
- W1965735440 hasConceptScore W1965735440C146556889 @default.
- W1965735440 hasConceptScore W1965735440C155710745 @default.
- W1965735440 hasConceptScore W1965735440C164705383 @default.
- W1965735440 hasConceptScore W1965735440C178853913 @default.
- W1965735440 hasConceptScore W1965735440C2778198053 @default.
- W1965735440 hasConceptScore W1965735440C2780529135 @default.
- W1965735440 hasConceptScore W1965735440C39133596 @default.
- W1965735440 hasConceptScore W1965735440C71924100 @default.
- W1965735440 hasIssue "5" @default.
- W1965735440 hasLocation W19657354401 @default.
- W1965735440 hasLocation W19657354402 @default.
- W1965735440 hasOpenAccess W1965735440 @default.
- W1965735440 hasPrimaryLocation W19657354401 @default.
- W1965735440 hasRelatedWork W154973431 @default.
- W1965735440 hasRelatedWork W1972950907 @default.
- W1965735440 hasRelatedWork W1992885869 @default.
- W1965735440 hasRelatedWork W1999953644 @default.
- W1965735440 hasRelatedWork W2003178526 @default.
- W1965735440 hasRelatedWork W2072650593 @default.
- W1965735440 hasRelatedWork W2110329221 @default.
- W1965735440 hasRelatedWork W2169190460 @default.
- W1965735440 hasRelatedWork W2396116373 @default.
- W1965735440 hasRelatedWork W2412409856 @default.
- W1965735440 hasVolume "60" @default.
- W1965735440 isParatext "false" @default.
- W1965735440 isRetracted "false" @default.
- W1965735440 magId "1965735440" @default.
- W1965735440 workType "article" @default.