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• W1965735815 abstract "The impact of hypothermia on reperfusion-associated oxidative stress in postischemic skeletal muscle was evaluated in a small animal model of high-grade partial ischemia. The infrarenal aorta of heparinized Sprague-Dawley rats was clamped for 90 min, declamped, and then reperfused for 60 min. Previous characterization of this model with 51Cr-tagged microspheres revealed that hindlimb perfusion during aortic clamping continued at 16.6% of baseline values. Resting transmembrane potential difference (Em) and tissue malondialdehyde (MDA), lactate and high-energy phosphate content were determined in hindlimb skeletal muscle at baseline, during ischemia, and upon reperfusion. Four experimental groups (N = 7 in each group) were studied: control animals underwent aortic clamping and declamping; hypothermia animals underwent topical cooling of hindlimbs prior to aortic clamping, with muscle temperatures maintained between 5 and 15°C during ischemia; sham animals underwent midline laparotomy only; and hypothermia-sham animals underwent cooling and midline laparotomy only. During ischemia, resting Em(−mV) was significantly depolarized (P < 0.05 versus baseline) in control (74.9 ± 0.8 from 91.0 ± 0.1), hypothermia (64.4 ± 1.1 from 90.9 ± 0.3), and hypothermia-sham (67.2 ± 1.4 from 90.9 ± 0.4) animals. Upon reperfusion, resting Em remained depolarized in control animals (74.7 ± 1.6), while repolarization occurred in hypothermia (74.7 ± 1.6), while repolarization occurred in hypothermia (88.8 ± 1.1) and hypothermia-sham (90.7 ± 0.3) animals. Tissue MDA content (nmol/g wet tissue), a marker of phospholipid peroxidation, was markedly elevated (P < 0.05 versus baseline) during ischemia in control (121.5 ± 18.4 from 67.1 ± 7.2) and hypothermia (118.5 ± 18.7 from 66.8 ± 7.5) animals, and continued to increase upon reperfusion in control animals (190.5 ± 14.0; P < 0.05 versus ischemia), while returning to baseline values in hypothermia animals (77.0 ± 12.8; P = NS versus baseline). These data indicate that high-grade partial ischemia in skeletal muscle is accompanied by significant phospholipid peroxidation, and that antecedent regional hypothermia markedly attenuates subsequent and further reperfusion-associated oxidative injury." @default.
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• W1965735815 date "1992-10-01" @default.
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• W1965735815 title "Hypothermia relieves oxidative stress in reperfused skeletal muscle following partial ischemia" @default.
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• W1965735815 doi "https://doi.org/10.1016/0022-4804(92)90069-c" @default.
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