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- W1965740147 abstract "The role of cholesterol in rafts assembly has been demonstrated in both model membranes and living cells. Here, we used AFM-based force mapping to investigate the influence of different cholesterol levels (5-40%) on the rupture of phase-separated multicomponent lipid bilayers consisting of DOPC/sphingomyelin/cholesterol. We report breakthrough forces for the coexisting phases, liquid ordered domains (Lo) and fluid disordered phase (Ld), at various loading rates. Breakthrough forces for both Lo and Ld phases increase with higher loading rate and decrease with increasing cholesterol concentration, consistent with the role of cholesterol in the formation of liquid ordered state. The breakthrough activation energies (30-60 kJ/mol) were calculated following the model for rupture of molecular thin films and compare favourably with reported values for the diffusion of lipid molecules in phosholipid bilayers using other techniques. This work has demonstrated the effective use of AFM-based force mapping to study the influence of cholesterol concentration on the nanomechanical stability of the coexisting phases of model membranes, providing fundamental nanomechanical insights on the role of cholesterol in the formation and stability of sphingolipid/cholesterol-enriched domains or rafts." @default.
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- W1965740147 date "2010-01-01" @default.
- W1965740147 modified "2023-09-27" @default.
- W1965740147 title "Cholesterol-Dependence of the Rupture Activation Energy in Phase-Segregated Multicomponent Lipid Bilayers" @default.
- W1965740147 doi "https://doi.org/10.1016/j.bpj.2009.12.1096" @default.
- W1965740147 hasPublicationYear "2010" @default.
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