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• W1965764907 abstract "Cognitive and motor deficits have been proposed as markers of abnormal neurodevelopment in schizophrenia and have been associated with genetic liability. In a multicenter study involving 106 subjects, 56 with deficit schizophrenia and 50 with nondeficit schizophrenia, we tested the hypothesis that the catechol-O-methyltransferase (COMT) Val¹⁵⁸Met polymorphism is associated with cognitive and motor deficits either in schizophrenia as a whole or in its deficit subtype. The COMT Val¹⁵⁸Met polymorphism shared 6.6% of the executive/attention dysfunction variance in patients with schizophrenia and 15.6% of the motor impairment variance in patients with deficit schizophrenia. These results support the hypothesis that the COMT Val¹⁵⁸Met polymorphism influences executive functions in schizophrenia and the neuromotor performance in the deficit subtype only." @default.
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• W1965764907 date "2005-01-01" @default.
• W1965764907 modified "2023-10-13" @default.
• W1965764907 title "Catechol-O-Methyltransferase Val¹⁵⁸Met Polymorphism in Schizophrenia: Associations with Cognitive and Motor Impairment" @default.
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• W1965764907 doi "https://doi.org/10.1159/000087096" @default.
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