FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965766734> ?p ?o ?g. }

• W1965766734 endingPage "35" @default.
• W1965766734 startingPage "27" @default.
• W1965766734 abstract "Dietary polyunsaturated fatty acids (ω-3 PUFAs) are associated with reduced coronary heart disease (CHD) risk. To define mechanisms, we investigated the vasoactive properties of these fatty acids in a rat model of hypercholesterolaemia (HC) and balloon arterial injury. Mature Wistar Kyoto (WKY) rats were fed a control (C), HC-inducing diet or a HC diet after aortic balloon injury (HC+EI) for 3 weeks. Serum cholesterol (mg/dL) was increased in HC (793±31) and HC+EI (857±36) as compared to C (85±3, p≤0.001). Cumulative concentration-response curves to norepinephrine (NE, 10−9 to 10−5 mol/L) followed by docosahexaenoic (DHA) or eicosapentaenoic (EPA) (1 to 100 μmol/L) were generated in isolated aortic rings (intact and de-endothelialised, E-). Overall, contractions to NE (10−9 to 10−5 mol/L) in intact rings were diminished in HC and HC+EI groups than were apparent in the C group (p≤0.001). De-endothelialised rings exhibited much greater NE contractile responses as compared to intact rings from each of the 3 groups. Endothelium-dependent relaxations to acetylcholine (10−7 to 10−4 mol/L) were significantly decreased in the HC+EI group. Relaxant responses to the ω-3 PUFAs, DHA and EPA (1–100 μmol/L) were similar in intact rings, but enhanced in E- rings among the 3 groups. De-endothelialised ring responses were −8.6 to −35.5% (C), −8.4 to −30.5% (HC), −7.8 to −25.6% (HC+EI) to DHA (1–100 μmol/L) and −6.8 to −339% (C), −4.8 to =t-40.8% (HC), −8.9 to −34.6% (HC+EI) to EPA (1–100 μmol/L). In areas of aortic intimal hyperplasia, lipid deposition quantified spectrophotometrically using oil red O (ORO) was greater in HC+EI (0.539 μmol ORO/mm2 aortic tissue, p<0.001) as compared to C (0.292) and HC (0.315) groups. We conclude that (1) aortic contractile properties to NE are altered in rats with HC and HC+EI, (2) dietary HC after aortic injury leads to intimal hyperplasia/lipid deposition and impaired endothelium-dependent relaxations in WKY rats, and (3) ω-3 PUFAs have vasorelaxant properties in HC and HC+EI rat aorta. These properties may be beneficial in CHD." @default.
• W1965766734 created "2016-06-24" @default.
• W1965766734 creator A5018699553 @default.
• W1965766734 creator A5027067083 @default.
• W1965766734 creator A5056146332 @default.
• W1965766734 creator A5083165548 @default.
• W1965766734 date "1999-05-01" @default.
• W1965766734 modified "2023-09-23" @default.
• W1965766734 title "Effects of the omega-3 fatty acids on vascular tone in hypercholesterolaemia and balloon arterial injury" @default.
• W1965766734 cites W1870633384 @default.
• W1965766734 cites W1910629691 @default.
• W1965766734 cites W1969244298 @default.
• W1965766734 cites W1981485427 @default.
• W1965766734 cites W1985244281 @default.
• W1965766734 cites W1985637499 @default.
• W1965766734 cites W1997359341 @default.
• W1965766734 cites W1999356575 @default.
• W1965766734 cites W2001870404 @default.
• W1965766734 cites W2004872829 @default.
• W1965766734 cites W2005629009 @default.
• W1965766734 cites W2010573884 @default.
• W1965766734 cites W2015669817 @default.
• W1965766734 cites W2026997553 @default.
• W1965766734 cites W2027987470 @default.
• W1965766734 cites W2041017781 @default.
• W1965766734 cites W2044857171 @default.
• W1965766734 cites W2047282670 @default.
• W1965766734 cites W2055176991 @default.
• W1965766734 cites W2059052527 @default.
• W1965766734 cites W2082228289 @default.
• W1965766734 cites W2083312867 @default.
• W1965766734 cites W2102430452 @default.
• W1965766734 cites W2105300548 @default.
• W1965766734 cites W2109942226 @default.
• W1965766734 cites W2123841491 @default.
• W1965766734 cites W2124459505 @default.
• W1965766734 cites W2137931278 @default.
• W1965766734 cites W2140647574 @default.
• W1965766734 cites W2151009828 @default.
• W1965766734 cites W2166154572 @default.
• W1965766734 cites W2315618879 @default.
• W1965766734 cites W2327897994 @default.
• W1965766734 cites W2341398312 @default.
• W1965766734 cites W2472201763 @default.
• W1965766734 cites W4236017105 @default.
• W1965766734 cites W4242697860 @default.
• W1965766734 cites W4243144783 @default.
• W1965766734 doi "https://doi.org/10.1016/s1328-0163(99)90006-4" @default.
• W1965766734 hasPublicationYear "1999" @default.
• W1965766734 type Work @default.
• W1965766734 sameAs 1965766734 @default.
• W1965766734 citedByCount "6" @default.
• W1965766734 crossrefType "journal-article" @default.
• W1965766734 hasAuthorship W1965766734A5018699553 @default.
• W1965766734 hasAuthorship W1965766734A5027067083 @default.
• W1965766734 hasAuthorship W1965766734A5056146332 @default.
• W1965766734 hasAuthorship W1965766734A5083165548 @default.
• W1965766734 hasConcept C120770815 @default.
• W1965766734 hasConcept C126322002 @default.
• W1965766734 hasConcept C134018914 @default.
• W1965766734 hasConcept C185592680 @default.
• W1965766734 hasConcept C19038510 @default.
• W1965766734 hasConcept C2776091944 @default.
• W1965766734 hasConcept C2777171753 @default.
• W1965766734 hasConcept C543025807 @default.
• W1965766734 hasConcept C55493867 @default.
• W1965766734 hasConcept C71924100 @default.
• W1965766734 hasConceptScore W1965766734C120770815 @default.
• W1965766734 hasConceptScore W1965766734C126322002 @default.
• W1965766734 hasConceptScore W1965766734C134018914 @default.
• W1965766734 hasConceptScore W1965766734C185592680 @default.
• W1965766734 hasConceptScore W1965766734C19038510 @default.
• W1965766734 hasConceptScore W1965766734C2776091944 @default.
• W1965766734 hasConceptScore W1965766734C2777171753 @default.
• W1965766734 hasConceptScore W1965766734C543025807 @default.
• W1965766734 hasConceptScore W1965766734C55493867 @default.
• W1965766734 hasConceptScore W1965766734C71924100 @default.
• W1965766734 hasIssue "1" @default.
• W1965766734 hasLocation W19657667341 @default.
• W1965766734 hasOpenAccess W1965766734 @default.
• W1965766734 hasPrimaryLocation W19657667341 @default.
• W1965766734 hasRelatedWork W1969244298 @default.
• W1965766734 hasRelatedWork W1984929305 @default.
• W1965766734 hasRelatedWork W1990478119 @default.
• W1965766734 hasRelatedWork W2056651897 @default.
• W1965766734 hasRelatedWork W2110419883 @default.
• W1965766734 hasRelatedWork W2748952813 @default.
• W1965766734 hasRelatedWork W2946715403 @default.
• W1965766734 hasRelatedWork W2980417694 @default.
• W1965766734 hasRelatedWork W4254513601 @default.
• W1965766734 hasRelatedWork W4293585428 @default.
• W1965766734 hasVolume "8" @default.
• W1965766734 isParatext "false" @default.
• W1965766734 isRetracted "false" @default.
• W1965766734 magId "1965766734" @default.
• W1965766734 workType "article" @default.