Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965772734> ?p ?o ?g. }
- W1965772734 endingPage "7695" @default.
- W1965772734 startingPage "7684" @default.
- W1965772734 abstract "Axonal growth cones are responsible for the correct guidance of developing axons and the establishment of functional neural networks. They are highly motile because of fast and continuous rearrangements of their actin-rich cytoskeleton. Here we have used live imaging of axonal growth cones of hippocampal neurons in culture and quantified their motility with a temporal resolution of 2 s. Using novel methods of analysis of growth cone dynamics, we show that transient activation of kainate receptors by bath-applied kainate induced a fast and reversible growth cone stalling. This effect depends on electrical activity and can be mimicked by the transient discharge of action potentials elicited in the neuron by intracellular current injections at the somatic level through a patch pipette. Growth cone stalling induced by electrical stimulation is mediated by calcium entry from the extracellular medium as well as by calcium release from intracellular stores that define spatially restricted microdomains directly affecting cytoskeletal dynamics. We propose that growth cone motility is dynamically controlled by transient bursts of spontaneous electrical activity, which constitutes a prominent feature of developing neural networks in vivo ." @default.
- W1965772734 created "2016-06-24" @default.
- W1965772734 creator A5029470622 @default.
- W1965772734 creator A5040635923 @default.
- W1965772734 creator A5069894225 @default.
- W1965772734 creator A5077824291 @default.
- W1965772734 creator A5087269217 @default.
- W1965772734 date "2007-07-18" @default.
- W1965772734 modified "2023-10-10" @default.
- W1965772734 title "Fast Regulation of Axonal Growth Cone Motility by Electrical Activity" @default.
- W1965772734 cites W1479736082 @default.
- W1965772734 cites W1511814572 @default.
- W1965772734 cites W1557599121 @default.
- W1965772734 cites W1578782149 @default.
- W1965772734 cites W1891766120 @default.
- W1965772734 cites W1964165361 @default.
- W1965772734 cites W1975257159 @default.
- W1965772734 cites W1975720936 @default.
- W1965772734 cites W1976013316 @default.
- W1965772734 cites W1978605718 @default.
- W1965772734 cites W1989244218 @default.
- W1965772734 cites W1991770248 @default.
- W1965772734 cites W1999739054 @default.
- W1965772734 cites W2006541743 @default.
- W1965772734 cites W2011931940 @default.
- W1965772734 cites W2019220811 @default.
- W1965772734 cites W2026351583 @default.
- W1965772734 cites W2026463319 @default.
- W1965772734 cites W2030446659 @default.
- W1965772734 cites W2031489662 @default.
- W1965772734 cites W2041844713 @default.
- W1965772734 cites W2042183685 @default.
- W1965772734 cites W2046046616 @default.
- W1965772734 cites W2060161122 @default.
- W1965772734 cites W2061207726 @default.
- W1965772734 cites W2062061647 @default.
- W1965772734 cites W2066129669 @default.
- W1965772734 cites W2068242052 @default.
- W1965772734 cites W2078047724 @default.
- W1965772734 cites W2081831423 @default.
- W1965772734 cites W2082089816 @default.
- W1965772734 cites W2082692141 @default.
- W1965772734 cites W2085287004 @default.
- W1965772734 cites W2089695334 @default.
- W1965772734 cites W2096471419 @default.
- W1965772734 cites W2104175189 @default.
- W1965772734 cites W2106820442 @default.
- W1965772734 cites W2122054000 @default.
- W1965772734 cites W2134230622 @default.
- W1965772734 cites W2136197879 @default.
- W1965772734 cites W2136706395 @default.
- W1965772734 cites W2141062015 @default.
- W1965772734 cites W2152678528 @default.
- W1965772734 cites W2160834780 @default.
- W1965772734 cites W2161496609 @default.
- W1965772734 cites W2169800968 @default.
- W1965772734 cites W2471454750 @default.
- W1965772734 cites W3189173254 @default.
- W1965772734 cites W68973889 @default.
- W1965772734 doi "https://doi.org/10.1523/jneurosci.1070-07.2007" @default.
- W1965772734 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6672867" @default.
- W1965772734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17634363" @default.
- W1965772734 hasPublicationYear "2007" @default.
- W1965772734 type Work @default.
- W1965772734 sameAs 1965772734 @default.
- W1965772734 citedByCount "45" @default.
- W1965772734 countsByYear W19657727342012 @default.
- W1965772734 countsByYear W19657727342013 @default.
- W1965772734 countsByYear W19657727342014 @default.
- W1965772734 countsByYear W19657727342015 @default.
- W1965772734 countsByYear W19657727342016 @default.
- W1965772734 countsByYear W19657727342017 @default.
- W1965772734 countsByYear W19657727342018 @default.
- W1965772734 countsByYear W19657727342019 @default.
- W1965772734 countsByYear W19657727342020 @default.
- W1965772734 countsByYear W19657727342021 @default.
- W1965772734 countsByYear W19657727342022 @default.
- W1965772734 crossrefType "journal-article" @default.
- W1965772734 hasAuthorship W1965772734A5029470622 @default.
- W1965772734 hasAuthorship W1965772734A5040635923 @default.
- W1965772734 hasAuthorship W1965772734A5069894225 @default.
- W1965772734 hasAuthorship W1965772734A5077824291 @default.
- W1965772734 hasAuthorship W1965772734A5087269217 @default.
- W1965772734 hasBestOaLocation W19657727341 @default.
- W1965772734 hasConcept C12554922 @default.
- W1965772734 hasConcept C135903288 @default.
- W1965772734 hasConcept C142669718 @default.
- W1965772734 hasConcept C148762608 @default.
- W1965772734 hasConcept C1491633281 @default.
- W1965772734 hasConcept C160268369 @default.
- W1965772734 hasConcept C169760540 @default.
- W1965772734 hasConcept C170493617 @default.
- W1965772734 hasConcept C181080969 @default.
- W1965772734 hasConcept C189184402 @default.
- W1965772734 hasConcept C2779530196 @default.
- W1965772734 hasConcept C55493867 @default.
- W1965772734 hasConcept C58207958 @default.
- W1965772734 hasConcept C67018056 @default.