FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965773758> ?p ?o ?g. }

• W1965773758 abstract "As Alzheimer's disease (AD) progresses many sufferers experience additional behavioural and psychological symptoms such as psychosis. Psychotic symptoms are reported to affect 30–60% of individuals with AD and are associated with more rapid cognitive and functional decline, more severe cognitive impairment, premature institutionalization, and increased risk for agitated and aggressive behaviour. AD with psychosis (AD+P) shows significant familiality and evidence of linkage to specific chromosomal regions, one of which shows overlap with a region previously implicated in schizophrenia and bipolar affective disorder. We have previously shown association of an individual gene with both schizophrenia and the psychosis subtype of AD and consequently hypothesised that variants identified from a genome wide association (GWA) study of schizophrenia (O'Donovan et al., unpublished data) may influence risk for psychotic symptoms in AD. Our schizophrenia GWA study genotyped 479 cases with the Affymetrix GeneChip® 500K Mapping Array in concert with the Wellcome Trust Case Control Consortium study (WTCCC), allowing us to compare allele frequencies with 2937 controls from that study. We chose the twenty-one most positively associated markers from our schizophrenia GWA study and individually genotyped them in a sample of 1205 Caucasian cases of late onset AD (NINCDS-ADRDA criteria) and 1361 aged matched controls from the UK, using the MassARRAY and iPlex systems (Sequenom, San Diego, CA). Preliminary results indicate two nominally significant associations. One marker shows a significant association with psychosis in AD (P = 0.014), while another polymorphism is significantly associated with AD alone (P = 0.019). Full data will be presented. Initial analysis of variants identified from our GWA study of schizophrenia show some evidence of association in both AD+P and AD. These results could support the existence of common aetiological factors influencing common psychotic symptoms on the background of multiple disorders. Alternatively, our results could indicate a complex relationship of psychosis aetiology across diseases, highlighting factors which may show stronger effect in a more severe/homogenous form of AD." @default.
• W1965773758 created "2016-06-24" @default.
• W1965773758 creator A5002493210 @default.
• W1965773758 creator A5003164142 @default.
• W1965773758 creator A5008236816 @default.
• W1965773758 creator A5008901063 @default.
• W1965773758 creator A5009402007 @default.
• W1965773758 creator A5023752531 @default.
• W1965773758 creator A5028228908 @default.
• W1965773758 creator A5030438682 @default.
• W1965773758 creator A5032293722 @default.
• W1965773758 creator A5033759880 @default.
• W1965773758 creator A5036497300 @default.
• W1965773758 creator A5040508278 @default.
• W1965773758 creator A5040824243 @default.
• W1965773758 creator A5041955176 @default.
• W1965773758 creator A5059458620 @default.
• W1965773758 creator A5065863382 @default.
• W1965773758 creator A5073614894 @default.
• W1965773758 creator A5076728928 @default.
• W1965773758 creator A5077494883 @default.
• W1965773758 creator A5085651175 @default.
• W1965773758 creator A5088279659 @default.
• W1965773758 creator A5090928688 @default.
• W1965773758 date "2008-07-01" @default.
• W1965773758 modified "2023-10-18" @default.
• W1965773758 title "P3-265: Testing for association between Alzheimer's disease with psychosis and variants identified as influencing risk of schizophrenia" @default.
• W1965773758 doi "https://doi.org/10.1016/j.jalz.2008.05.1833" @default.
• W1965773758 hasPublicationYear "2008" @default.
• W1965773758 type Work @default.
• W1965773758 sameAs 1965773758 @default.
• W1965773758 citedByCount "0" @default.
• W1965773758 crossrefType "journal-article" @default.
• W1965773758 hasAuthorship W1965773758A5002493210 @default.
• W1965773758 hasAuthorship W1965773758A5003164142 @default.
• W1965773758 hasAuthorship W1965773758A5008236816 @default.
• W1965773758 hasAuthorship W1965773758A5008901063 @default.
• W1965773758 hasAuthorship W1965773758A5009402007 @default.
• W1965773758 hasAuthorship W1965773758A5023752531 @default.
• W1965773758 hasAuthorship W1965773758A5028228908 @default.
• W1965773758 hasAuthorship W1965773758A5030438682 @default.
• W1965773758 hasAuthorship W1965773758A5032293722 @default.
• W1965773758 hasAuthorship W1965773758A5033759880 @default.
• W1965773758 hasAuthorship W1965773758A5036497300 @default.
• W1965773758 hasAuthorship W1965773758A5040508278 @default.
• W1965773758 hasAuthorship W1965773758A5040824243 @default.
• W1965773758 hasAuthorship W1965773758A5041955176 @default.
• W1965773758 hasAuthorship W1965773758A5059458620 @default.
• W1965773758 hasAuthorship W1965773758A5065863382 @default.
• W1965773758 hasAuthorship W1965773758A5073614894 @default.
• W1965773758 hasAuthorship W1965773758A5076728928 @default.
• W1965773758 hasAuthorship W1965773758A5077494883 @default.
• W1965773758 hasAuthorship W1965773758A5085651175 @default.
• W1965773758 hasAuthorship W1965773758A5088279659 @default.
• W1965773758 hasAuthorship W1965773758A5090928688 @default.
• W1965773758 hasConcept C104317684 @default.
• W1965773758 hasConcept C106208931 @default.
• W1965773758 hasConcept C118552586 @default.
• W1965773758 hasConcept C126322002 @default.
• W1965773758 hasConcept C135763542 @default.
• W1965773758 hasConcept C142853389 @default.
• W1965773758 hasConcept C153209595 @default.
• W1965773758 hasConcept C15744967 @default.
• W1965773758 hasConcept C180754005 @default.
• W1965773758 hasConcept C186413461 @default.
• W1965773758 hasConcept C2776412080 @default.
• W1965773758 hasConcept C2779134260 @default.
• W1965773758 hasConcept C2779727114 @default.
• W1965773758 hasConcept C2984915365 @default.
• W1965773758 hasConcept C542102704 @default.
• W1965773758 hasConcept C54355233 @default.
• W1965773758 hasConcept C70410870 @default.
• W1965773758 hasConcept C71924100 @default.
• W1965773758 hasConcept C86803240 @default.
• W1965773758 hasConceptScore W1965773758C104317684 @default.
• W1965773758 hasConceptScore W1965773758C106208931 @default.
• W1965773758 hasConceptScore W1965773758C118552586 @default.
• W1965773758 hasConceptScore W1965773758C126322002 @default.
• W1965773758 hasConceptScore W1965773758C135763542 @default.
• W1965773758 hasConceptScore W1965773758C142853389 @default.
• W1965773758 hasConceptScore W1965773758C153209595 @default.
• W1965773758 hasConceptScore W1965773758C15744967 @default.
• W1965773758 hasConceptScore W1965773758C180754005 @default.
• W1965773758 hasConceptScore W1965773758C186413461 @default.
• W1965773758 hasConceptScore W1965773758C2776412080 @default.
• W1965773758 hasConceptScore W1965773758C2779134260 @default.
• W1965773758 hasConceptScore W1965773758C2779727114 @default.
• W1965773758 hasConceptScore W1965773758C2984915365 @default.
• W1965773758 hasConceptScore W1965773758C542102704 @default.
• W1965773758 hasConceptScore W1965773758C54355233 @default.
• W1965773758 hasConceptScore W1965773758C70410870 @default.
• W1965773758 hasConceptScore W1965773758C71924100 @default.
• W1965773758 hasConceptScore W1965773758C86803240 @default.
• W1965773758 hasIssue "4S_Part_18" @default.
• W1965773758 hasLocation W19657737581 @default.
• W1965773758 hasOpenAccess W1965773758 @default.
• W1965773758 hasPrimaryLocation W19657737581 @default.
• W1965773758 hasRelatedWork W16196038 @default.
• W1965773758 hasRelatedWork W1976740474 @default.
• W1965773758 hasRelatedWork W1990938045 @default.

• next