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- W1965777729 endingPage "323" @default.
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- W1965777729 abstract "The product of a proto-oncogene, the c-Met protein is a transmembrane receptor tyrosine kinase. Its only known ligand, hepatocyte growth factor/scatter factor, regulates cell growth, motility, migration, invasion, proliferation, and angiogenesis. Dysregulation of c-Met and hepatocyte growth factor have been observed in both clear cell and non–clear cell renal cell carcinomas (RCCs), although only papillary RCCs harbor activating mutations in the MET gene. In clear cell RCC, there is evidence of a direct link between loss of von Hippel–Lindau and up-regulation of c-Met. As in other cancers, high expression of c-Met correlates with worse outcomes in RCC. In vitro and in vivo preclinical RCC models demonstrate cancer control with small molecule and antibodies against c-Met. Given these findings, the c-Met pathway is a logical therapeutic target in RCC, and several agents are in clinical testing with early signs of efficacy." @default.
- W1965777729 created "2016-06-24" @default.
- W1965777729 creator A5052504518 @default.
- W1965777729 creator A5055738663 @default.
- W1965777729 date "2013-07-01" @default.
- W1965777729 modified "2023-10-18" @default.
- W1965777729 title "Targeting the Hepatocyte Growth Factor/c-Met Signaling Pathway in Renal Cell Carcinoma" @default.
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- W1965777729 doi "https://doi.org/10.1097/ppo.0b013e31829e3c9a" @default.
- W1965777729 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23867513" @default.
- W1965777729 hasPublicationYear "2013" @default.
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