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- W1965794328 abstract "In spite of the long established clinical relevance of neurogenic dysphagia, clarification of the central control of deglutition is the object of ongoing research. While central swallowing pattern generators in the brainstem control the involuntary swallowing reflex, the cerebral cortex plays a decisive role in the voluntary initiation of deglutition. Physiological deglutition is processed bilaterally in the sensorimotor cortex and in several additional cortical and subcortical brain regions. Clinical observations in stroke patients and recent imaging studies suggest hemispheric specialisations for the different phases of deglutition. Predominantly left lateralised processing of the oral phase and right hemispheric lateralisation of the pharyngeal phase are assumed. Adaptation and compensation mechanisms have moreover been shown for pathological and iatrogenic changes. Lesions of the upper motor neuron result in a decrease of swallowing-related cortical activation. In the case of unilateral affection as in stroke, reorganisation processes can be observed parallel to clinical recovery. Lesions beyond the upper motor neuron, e.g., bulbospinal muscle atrophy, typically result in an increase of the cortical representation of swallowing. We assume that the hitherto existing results will be of value for the development of new therapies and their evaluation." @default.
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- W1965794328 date "2009-09-01" @default.
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- W1965794328 title "Kortikale Repräsentation des Schluckaktes – Neues zur Physiologie und Pathophysiologie des Schluckens" @default.
- W1965794328 doi "https://doi.org/10.1055/s-0029-1202780" @default.
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