FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965798892> ?p ?o ?g. }

• W1965798892 endingPage "3696" @default.
• W1965798892 startingPage "3691" @default.
• W1965798892 abstract "Phytoestrogens (PE) including isoflavones and lignans, are a group of substances of plant origin which can act as estrogen agonists or antagonists. While the immunomodulatory effects of isoflavones have been studied, little is known about the impact of lignans and other PE metabolites on the immune system. The aim of the present study was to assess whether PE and their metabolites modulate human leukocyte functions in vitro. We investigated the effects of genistein, daidzein, matairesinol, and secoisolariciresinol, including metabolites such as equol, O-desmethylangolensin, enterodiol, and enterolactone on natural killer cell activity, proliferation, cytokine secretion, as well as apoptotic and necrotic rate of human leukocytes. Genistein, daidzein, and its metabolite equol were the most potent inhibitors of leukocyte functions. Ten micromolars of genistein decreased proliferation, lytic activity of natural killer cells, and cytokine secretions. The latter proved to be the most sensitive marker of immune functions. Lignans and their metabolites had minor effects on the immune system. The antiestrogens Tamoxifen and Fulvestrant did not block the inhibition of cytokine secretion by genistein and equol. In conclusion, while physiological concentrations of isoflavones have minor effects on cytokine secretion, lignans including their major metabolites do not modulate human leukocyte functions in vitro." @default.
• W1965798892 created "2016-06-24" @default.
• W1965798892 creator A5007932890 @default.
• W1965798892 creator A5016835889 @default.
• W1965798892 creator A5052300069 @default.
• W1965798892 creator A5072185631 @default.
• W1965798892 date "2008-12-01" @default.
• W1965798892 modified "2023-09-24" @default.
• W1965798892 title "Phytoestrogens and phytoestrogen metabolites differentially modulate immune parameters in human leukocytes" @default.
• W1965798892 cites W1693873790 @default.
• W1965798892 cites W1937331953 @default.
• W1965798892 cites W1964535481 @default.
• W1965798892 cites W1968630327 @default.
• W1965798892 cites W1968814123 @default.
• W1965798892 cites W1980743395 @default.
• W1965798892 cites W1984536165 @default.
• W1965798892 cites W1985389505 @default.
• W1965798892 cites W1994998746 @default.
• W1965798892 cites W2009527950 @default.
• W1965798892 cites W2011036671 @default.
• W1965798892 cites W2018056834 @default.
• W1965798892 cites W2023157569 @default.
• W1965798892 cites W2027836418 @default.
• W1965798892 cites W2029104340 @default.
• W1965798892 cites W2031951919 @default.
• W1965798892 cites W2032853997 @default.
• W1965798892 cites W2033987141 @default.
• W1965798892 cites W2034359758 @default.
• W1965798892 cites W2036843530 @default.
• W1965798892 cites W2046698026 @default.
• W1965798892 cites W2051185023 @default.
• W1965798892 cites W2054614576 @default.
• W1965798892 cites W2059294789 @default.
• W1965798892 cites W2067283379 @default.
• W1965798892 cites W2071369173 @default.
• W1965798892 cites W2073200876 @default.
• W1965798892 cites W2085387078 @default.
• W1965798892 cites W2135214844 @default.
• W1965798892 cites W2139259865 @default.
• W1965798892 cites W2147235488 @default.
• W1965798892 cites W2148220584 @default.
• W1965798892 cites W2151040483 @default.
• W1965798892 cites W2151837338 @default.
• W1965798892 cites W2165730820 @default.
• W1965798892 cites W2246091553 @default.
• W1965798892 cites W2325595519 @default.
• W1965798892 cites W3144493907 @default.
• W1965798892 doi "https://doi.org/10.1016/j.fct.2008.09.047" @default.
• W1965798892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18929616" @default.
• W1965798892 hasPublicationYear "2008" @default.
• W1965798892 type Work @default.
• W1965798892 sameAs 1965798892 @default.
• W1965798892 citedByCount "20" @default.
• W1965798892 countsByYear W19657988922012 @default.
• W1965798892 countsByYear W19657988922013 @default.
• W1965798892 countsByYear W19657988922014 @default.
• W1965798892 countsByYear W19657988922015 @default.
• W1965798892 countsByYear W19657988922016 @default.
• W1965798892 countsByYear W19657988922018 @default.
• W1965798892 countsByYear W19657988922019 @default.
• W1965798892 countsByYear W19657988922021 @default.
• W1965798892 countsByYear W19657988922022 @default.
• W1965798892 crossrefType "journal-article" @default.
• W1965798892 hasAuthorship W1965798892A5007932890 @default.
• W1965798892 hasAuthorship W1965798892A5016835889 @default.
• W1965798892 hasAuthorship W1965798892A5052300069 @default.
• W1965798892 hasAuthorship W1965798892A5072185631 @default.
• W1965798892 hasConcept C126322002 @default.
• W1965798892 hasConcept C134018914 @default.
• W1965798892 hasConcept C185592680 @default.
• W1965798892 hasConcept C203014093 @default.
• W1965798892 hasConcept C2777164284 @default.
• W1965798892 hasConcept C2777477808 @default.
• W1965798892 hasConcept C2777927066 @default.
• W1965798892 hasConcept C2778270713 @default.
• W1965798892 hasConcept C2778298627 @default.
• W1965798892 hasConcept C2778690821 @default.
• W1965798892 hasConcept C2778821405 @default.
• W1965798892 hasConcept C2779705811 @default.
• W1965798892 hasConcept C2780955279 @default.
• W1965798892 hasConcept C2781262405 @default.
• W1965798892 hasConcept C71924100 @default.
• W1965798892 hasConcept C86803240 @default.
• W1965798892 hasConcept C8891405 @default.
• W1965798892 hasConcept C98274493 @default.
• W1965798892 hasConceptScore W1965798892C126322002 @default.
• W1965798892 hasConceptScore W1965798892C134018914 @default.
• W1965798892 hasConceptScore W1965798892C185592680 @default.
• W1965798892 hasConceptScore W1965798892C203014093 @default.
• W1965798892 hasConceptScore W1965798892C2777164284 @default.
• W1965798892 hasConceptScore W1965798892C2777477808 @default.
• W1965798892 hasConceptScore W1965798892C2777927066 @default.
• W1965798892 hasConceptScore W1965798892C2778270713 @default.
• W1965798892 hasConceptScore W1965798892C2778298627 @default.
• W1965798892 hasConceptScore W1965798892C2778690821 @default.
• W1965798892 hasConceptScore W1965798892C2778821405 @default.
• W1965798892 hasConceptScore W1965798892C2779705811 @default.
• W1965798892 hasConceptScore W1965798892C2780955279 @default.

• next