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- W1965804539 abstract "Fez is a zinc-finger gene encoding a transcriptional repressor that is expressed in the olfactory epithelium, hypothalamus, ventrolateral pallium and prethalamus at mid-gestation. To reveal its function, we generated Fez-deficient mice. The Fez-deficient mice showed several abnormalities in the olfactory system: (1) impaired axonal projection of the olfactory sensory neurons; (2) reduced size of the olfactory bulb; (3)abnormal layer formation in the olfactory bulb; and (4) aberrant rostral migration of the interneuron progenitors. Fez was not expressed in the projection neurons, interneurons or interneuron progenitors. Transgene-mediated expression of Fez in olfactory sensory neurons significantly rescued the abnormalities in olfactory axon projection and in the morphogenesis of the olfactory bulb in Fez-knockout mice. Thus, Fez is cell-autonomously required for the axon termination of olfactory sensory neurons, and Fez non-cell-autonomously controls layer formation and interneuron development in the olfactory bulb. These findings suggest that signals from olfactory sensory neurons contribute to the proper formation of the olfactory bulb." @default.
- W1965804539 created "2016-06-24" @default.
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- W1965804539 date "2006-04-15" @default.
- W1965804539 modified "2023-09-23" @default.
- W1965804539 title "Zinc-finger gene<i>Fez</i>in the olfactory sensory neurons regulates development of the olfactory bulb non-cell-autonomously" @default.
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- W1965804539 doi "https://doi.org/10.1242/dev.02329" @default.
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