FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965805135> ?p ?o ?g. }

• W1965805135 endingPage "3155" @default.
• W1965805135 startingPage "3148" @default.
• W1965805135 abstract "The impact of testosterone on cardiac expression of heat-shock protein 72 (HSP72) remains to be elucidated. Male Sprague Dawley rats 10 wk of age (adult) were castrated. Four weeks later, testosterone (10 mg/kg, ip) was administered as a single dose, followed by the application of hyperthermia (HT) (43 C) at 6 h after testosterone administration. Twenty-four hours later, each heart was isolated. Cardiomyocytes were prepared from 3- to 5-d-old Wistar rats and male Sprague Dawley rats 10 wk of age. Testosterone (0.1–10 μm) was added to the medium, followed by the application of HT (42 C). Twenty-four hours later, cells were collected. We observed the following: 1) Exogenous testosterone suppressed HT-induced HSP72 expression, but castration alone had no influence. 2) HT resulted in better reperfusion-induced cardiac performance in castrated rats comparable with sham-operated rats, which was inhibited by testosterone. The number of apoptotic cells after ischemia/reperfusion was also increased by testosterone. 3) HT-induced HSP72 expression in cultured cardiomyocytes was suppressed by testosterone. 4) HT resulted in less damage to cells, including apoptosis, in response to hypoxia/reoxygenation, which was inhibited by testosterone. 5) Flutamide, a testosterone receptor blocker, cancelled the suppressive effects of testosterone on HSP72 expression. 6) The HT-induced increase in heat-shock factor 1 activity to bind to heat-shock element DNA was suppressed by testosterone, and this was reversed by flutamide. Our results indicate that testosterone potentially has inhibitory effects on cardiac HSP72 expression by modulating transcription, through testosterone receptor-mediated genomic mechanisms." @default.
• W1965805135 created "2016-06-24" @default.
• W1965805135 creator A5016896787 @default.
• W1965805135 creator A5022840525 @default.
• W1965805135 creator A5039110613 @default.
• W1965805135 creator A5039385401 @default.
• W1965805135 creator A5041554301 @default.
• W1965805135 creator A5046310953 @default.
• W1965805135 creator A5047375952 @default.
• W1965805135 creator A5054754622 @default.
• W1965805135 creator A5070474200 @default.
• W1965805135 creator A5086686622 @default.
• W1965805135 date "2007-07-01" @default.
• W1965805135 modified "2023-09-26" @default.
• W1965805135 title "Receptor-Mediated Suppression of Cardiac Heat-Shock Protein 72 Expression by Testosterone in Male Rat Heart" @default.
• W1965805135 cites W1598733586 @default.
• W1965805135 cites W1964129966 @default.
• W1965805135 cites W1973799408 @default.
• W1965805135 cites W1978221784 @default.
• W1965805135 cites W1995486984 @default.
• W1965805135 cites W2003666655 @default.
• W1965805135 cites W2007299033 @default.
• W1965805135 cites W2014027548 @default.
• W1965805135 cites W2018368054 @default.
• W1965805135 cites W2022057523 @default.
• W1965805135 cites W2026075137 @default.
• W1965805135 cites W2044945917 @default.
• W1965805135 cites W2072433251 @default.
• W1965805135 cites W2084794120 @default.
• W1965805135 cites W2085231390 @default.
• W1965805135 cites W2102899157 @default.
• W1965805135 cites W2123421042 @default.
• W1965805135 cites W2123878234 @default.
• W1965805135 cites W2125809788 @default.
• W1965805135 cites W2140735579 @default.
• W1965805135 cites W2143797732 @default.
• W1965805135 cites W2151007116 @default.
• W1965805135 cites W2152312364 @default.
• W1965805135 cites W2153469530 @default.
• W1965805135 cites W2161612659 @default.
• W1965805135 cites W2171478415 @default.
• W1965805135 cites W2325814559 @default.
• W1965805135 doi "https://doi.org/10.1210/en.2006-1581" @default.
• W1965805135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17395695" @default.
• W1965805135 hasPublicationYear "2007" @default.
• W1965805135 type Work @default.
• W1965805135 sameAs 1965805135 @default.
• W1965805135 citedByCount "21" @default.
• W1965805135 countsByYear W19658051352012 @default.
• W1965805135 countsByYear W19658051352013 @default.
• W1965805135 countsByYear W19658051352014 @default.
• W1965805135 countsByYear W19658051352018 @default.
• W1965805135 countsByYear W19658051352019 @default.
• W1965805135 countsByYear W19658051352020 @default.
• W1965805135 countsByYear W19658051352021 @default.
• W1965805135 crossrefType "journal-article" @default.
• W1965805135 hasAuthorship W1965805135A5016896787 @default.
• W1965805135 hasAuthorship W1965805135A5022840525 @default.
• W1965805135 hasAuthorship W1965805135A5039110613 @default.
• W1965805135 hasAuthorship W1965805135A5039385401 @default.
• W1965805135 hasAuthorship W1965805135A5041554301 @default.
• W1965805135 hasAuthorship W1965805135A5046310953 @default.
• W1965805135 hasAuthorship W1965805135A5047375952 @default.
• W1965805135 hasAuthorship W1965805135A5054754622 @default.
• W1965805135 hasAuthorship W1965805135A5070474200 @default.
• W1965805135 hasAuthorship W1965805135A5086686622 @default.
• W1965805135 hasBestOaLocation W19658051351 @default.
• W1965805135 hasConcept C104317684 @default.
• W1965805135 hasConcept C121608353 @default.
• W1965805135 hasConcept C126322002 @default.
• W1965805135 hasConcept C134018914 @default.
• W1965805135 hasConcept C170493617 @default.
• W1965805135 hasConcept C185592680 @default.
• W1965805135 hasConcept C205260736 @default.
• W1965805135 hasConcept C2778313021 @default.
• W1965805135 hasConcept C2779256933 @default.
• W1965805135 hasConcept C2779279991 @default.
• W1965805135 hasConcept C2780192828 @default.
• W1965805135 hasConcept C55493867 @default.
• W1965805135 hasConcept C61367390 @default.
• W1965805135 hasConcept C71315377 @default.
• W1965805135 hasConcept C71924100 @default.
• W1965805135 hasConceptScore W1965805135C104317684 @default.
• W1965805135 hasConceptScore W1965805135C121608353 @default.
• W1965805135 hasConceptScore W1965805135C126322002 @default.
• W1965805135 hasConceptScore W1965805135C134018914 @default.
• W1965805135 hasConceptScore W1965805135C170493617 @default.
• W1965805135 hasConceptScore W1965805135C185592680 @default.
• W1965805135 hasConceptScore W1965805135C205260736 @default.
• W1965805135 hasConceptScore W1965805135C2778313021 @default.
• W1965805135 hasConceptScore W1965805135C2779256933 @default.
• W1965805135 hasConceptScore W1965805135C2779279991 @default.
• W1965805135 hasConceptScore W1965805135C2780192828 @default.
• W1965805135 hasConceptScore W1965805135C55493867 @default.
• W1965805135 hasConceptScore W1965805135C61367390 @default.
• W1965805135 hasConceptScore W1965805135C71315377 @default.
• W1965805135 hasConceptScore W1965805135C71924100 @default.
• W1965805135 hasIssue "7" @default.

• next