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• W1965808894 abstract "It is now clearly established that anti-vascular endothelial growth factor (VEGF) drug class induces hypertension and proteinuria sometimes related to thrombotic microangiopathy and/or various glomerulopathies, according to capillary and glomerular VEGF and VEGF-receptor expressions. As reported in the literature, anti-epidermal growth factor receptor (EGFR) therapies seem to be less nephrotoxic. Indeed, many reports of anti-EGFR nephrotoxicity are tubular dependent such as acute tubular necrosis, electrolyte disorders (hypophosphatemia, hypomagnesemia, etc.) or both. This is explained by elective tubular expression of renal EGF/EGFR. In this paper, we focus on electrolyte disorders related to anti-EGFR treatment and discuss the tubular involvement of these drugs based on their renal expression." @default.
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• W1965808894 date "2010-03-01" @default.
• W1965808894 modified "2023-10-18" @default.
• W1965808894 title "Electrolyte disorders related to EGFR-targeting drugs" @default.
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• W1965808894 doi "https://doi.org/10.1016/j.critrevonc.2009.03.012" @default.
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