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- W1965823522 abstract "Future MicrobiologyVol. 6, No. 6 EditorialAre nonlethal targets useful for developing novel antimicrobials?José L Martínez, Fernando Rojo & Jordi VilaJosé L Martínez† Author for correspondenceDepartamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, CSIC, Darwin 3, Cantoblanco, 28049 Madrid, Spain. Search for more papers by this authorEmail the corresponding author at jlmtnez@cnb.csic.es, Fernando RojoDepartamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, CSIC, Darwin 3, Cantoblanco, 28049 Madrid, Spain. Search for more papers by this authorEmail the corresponding author at jlmtnez@cnb.csic.es & Jordi VilaDepartamento de Microbiología Clínica, Centro de Diagnóstico Biomédico, Hospital Clínic, CRESIB/IDIBAPS, Facultad de Medicina, Universidad de Barcelona, Barcelona, SpainSearch for more papers by this authorPublished Online:27 Jun 2011https://doi.org/10.2217/fmb.11.47AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: antivirulence antibioticsinhibitor of antibiotic resistanceMDRmultidrug resistancequorum sensingtype three secretionBibliography1 Lange RP, Locher HH, Wyss PC, Then RL: The targets of currently used antibacterial agents: lessons for drug discovery. Curr. Pharm. Des.13(30),3140–3154 (2007).Crossref, Medline, CAS, Google Scholar2 Reading C, Cole M: Clavulanic acid: a β-lactamase-inhibiting β-lactam from Streptomyces clavuligerus. 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Agents30(Suppl. 2),S139–S141 (2007).Crossref, Medline, CAS, Google Scholar7 Tan Q, Ogawa AM, Painter RE, Park YW, Young K, DiNinno FP: 4,7-dichloro benzothien-2-yl sulfonylaminomethyl boronic acid: first boronic acid-derived β-lactamase inhibitor with class A, C, and D activity. Bioorg. Med. Chem. Lett.20(8),2622–2624 (2010).Crossref, Medline, CAS, Google Scholar8 Kiener PA, Waley SG: Reversible inhibitors of penicillinases. Biochem. J.169(1),197–204 (1978).Crossref, Medline, CAS, Google Scholar9 Vila J, Martinez JL: Clinical impact of the over-expression of efflux pump in nonfermentative gram-negative bacilli, development of efflux pump inhibitors. Curr. Drug Targets9(9),797–807 (2008).Crossref, Medline, CAS, Google Scholar10 Lomovskaya O, Warren MS, Lee A et al.: Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy. Antimicrob. Agents Chemother.45(1),105–116 (2001).Crossref, Medline, CAS, Google Scholar11 Rasko DA, Sperandio V: Anti-virulence strategies to combat bacteria-mediated disease. Nat. Rev.9(2),117–128 (2010).Crossref, CAS, Google Scholar12 Hu Y, Xie GH, Chen QX, Fang XM: Small molecules in treatment of sepsis. Curr. Drug Targets12(2),256–262 (2011).Crossref, Medline, CAS, Google Scholar13 Rasko DA, Moreira CG, Li de R et al.: Targeting QseC signaling and virulence for antibiotic development. Science321(5892),1078–1080 (2008).Crossref, Medline, CAS, Google Scholar14 Fajardo A, Martinez-Martin N, Mercadillo M et al.: The neglected intrinsic resistome of bacterial pathogens. PLoS One3(2),e1619 (2008).Crossref, Medline, Google Scholar15 Tamae C, Liu A, Kim K et al.: Determination of antibiotic hypersensitivity among 4,000 single-gene-knockout mutants of Escherichia coli. J. Bacteriol.190(17),5981–5988 (2008).Crossref, Medline, CAS, Google Scholar16 Alvarez-Ortega C, Wiegand I, Olivares J, Hancock RE, Martinez JL: Genetic determinants involved in the susceptibility of Pseudomonas aeruginosa to β-lactam antibiotics. Antimicrob. Agents Chemother.54(10),4159–4167 (2010).Crossref, Medline, CAS, Google Scholar17 Linares JF, Moreno R, Fajardo A et al.: The global regulator Crc modulates metabolism, susceptibility to antibiotics and virulence in Pseudomonas aeruginosa. Environ. Microbiol.12,3196–3212 (2010).Crossref, Medline, CAS, Google Scholar18 Martinez JL, Fajardo A, Garmendia L et al.: A global view of antibiotic resistance. FEMS Microbiol. Rev.33(1),44–65 (2009).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetailsCited BySynergy based Extracts of Medicinal Plants: Future Antimicrobials to Combat Multidrug ResistanceCurrent Pharmaceutical Biotechnology, Vol. 23, No. 13Antibacterial Activity Prediction of Plant Secondary Metabolites Based on a Combined Approach of Graph Clustering and Deep Neural Network28 January 2022 | Molecular Informatics, Vol. 41, No. 7Phylogenetic Analysis of Origanum vulgare and Its Antioxidant and Antimicrobial Activity1 June 2021 | Gazi University Journal of Science, Vol. 34, No. 2L-lysine potentiates aminoglycosides against Acinetobacter baumannii via regulation of proton motive force and antibiotics uptake20 March 2020 | Emerging Microbes & Infections, Vol. 9, No. 1Endemic and indigenous plants from Mauritius as sources of novel antimicrobialsSouth African Journal of Botany, Vol. 126Antibiotics: Pharmacokinetics, toxicity, resistance and multidrug efflux pumpsBiochemical Pharmacology, Vol. 133Phenotypic Resistance to Antibiotics18 April 2013 | Antibiotics, Vol. 2, No. 2Plant-derived antimicrobial compounds: alternatives to antibioticsDianella Savoia23 August 2012 | Future Microbiology, Vol. 7, No. 8The antibiotic resistome: challenge and opportunity for therapeutic interventionFuture Medicinal Chemistry, Vol. 4, No. 3Acinetobacter baumannii resistant to everything: what should we do?Clinical Microbiology and Infection, Vol. 17, No. 7Antimicrobial drug discoveryAlan Fairlamb & Stewart Cole27 June 2011 | Future Microbiology, Vol. 6, No. 6 Vol. 6, No. 6 STAY CONNECTED Metrics Downloaded 305 times History Published online 27 June 2011 Published in print June 2011 Information© Future Medicine LtdKeywordsantivirulence antibioticsinhibitor of antibiotic resistanceMDRmultidrug resistancequorum sensingtype three secretionFinancial & competing interests disclosureThe authors’ laboratories are supported by grants BIO2008–00090 and BFU2009–07009/BMC from the Spanish Ministry of Science and Innovation, Spanish Network for the Research in Infectious Diseases, REIPI RD06/0008 from the Instituto de Salud Carlos III, KBBE-227258 (BIOHYPO) and HEALTH-F3–2010–241476 (PAR) from the European Union. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download" @default.
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