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- W1965827688 abstract "Abstract Previous studies carried out with a limited number of human lymphoblastoid cell lines of B-cell origin concluded that B cells were relatively insensitive to cell killing by vesicular stomatitis virus (VSV) (Nowakowski et al., J. Virol. 12, 1272–1278, 1973; Creager et al., Virology 111, 211–222, 1981). The B-cell lines employed in those studies all contained endogenous Epstein-Barr virus (EBV). The present investigation was carried out using additional B-cell lines with and without endogenous EBV genomes. It was found that the presence of EBV in human B-lymphoblastoid cells has a marked influence on the outcome of infection by VSV. In the EBV-negative B-cell lines, few, if any, cells survived VSV infection. The EBV-positive B-cell lines responded quite differently: much less cytopathology occurred, and persistent infections invariably were established. These findings suggest that EBV may play a critical role in the response of human B-lymphoblastoid cell lines to VSV infection, especially in regard to cell killing and the establishment of VSV persistence. Although there was a striking difference in the ability of VSV to kill EBV-positive and EBV-negative B-cell lines, there was no correlation between cell destruction and the amount of viral RNA or progeny virus synthesized." @default.
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- W1965827688 date "1982-09-01" @default.
- W1965827688 modified "2023-09-27" @default.
- W1965827688 title "Varied responses of human B-lymphoblastoid cell lines to infection with vesicular stomatitis virus" @default.
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- W1965827688 doi "https://doi.org/10.1016/0042-6822(82)90179-9" @default.
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