FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965839780> ?p ?o ?g. }

• W1965839780 endingPage "965" @default.
• W1965839780 startingPage "958" @default.
• W1965839780 abstract "Interleukin-6 (IL-6) is a major growth factor in multiple myeloma. We investigated the effect of mouse anti-human IL-6 receptor monoclonal antibody (anti-IL-6R mAb) on the in vitro proliferation of freshly isolated myeloma cells from 21 patients to evaluate the therapeutic potential. The addition of anti-IL-6R mAb inhibited more than 30% of the spontaneous proliferation of myeloma cells in 9 of 21 cases in a dose- (0.1 to 20 /μ/ml) and time-dependent manner. The inhibitory effects of anti-IL-6R mAb did not differ significantly from that of anti-IL-6 mAb, and were correlated with the extent of the response of myeloma cells to IL-6. Flow cytometric analysis showed that all myeloma cells expressed IL-6R, whose intensity was not correlated with either the extent of response of myeloma cells to IL-6 or the inhibitory effects of anti-IL-6R mAb on proliferation of myeloma cells. Although our study showed heterogeneity in the proliferative responses of myeloma cells to IL-6 and anti-IL-6R mAb, these observations suggest the possibility of using anti-IL-6R mAbs for treating some patients with multiple myeloma whose growth depends on IL-6." @default.
• W1965839780 created "2016-06-24" @default.
• W1965839780 creator A5013826509 @default.
• W1965839780 creator A5024085053 @default.
• W1965839780 creator A5028550766 @default.
• W1965839780 creator A5031781312 @default.
• W1965839780 creator A5035512198 @default.
• W1965839780 creator A5047706524 @default.
• W1965839780 creator A5055948716 @default.
• W1965839780 creator A5056018649 @default.
• W1965839780 creator A5057544635 @default.
• W1965839780 creator A5071371446 @default.
• W1965839780 creator A5081363686 @default.
• W1965839780 creator A5082139165 @default.
• W1965839780 date "1994-09-01" @default.
• W1965839780 modified "2023-09-27" @default.
• W1965839780 title "Mouse Anti-human Interleukin-6 Receptor Monoclonal Antibody Inhibits Proliferation of Fresh Human Myeloma Cells in vitro" @default.
• W1965839780 cites W134083461 @default.
• W1965839780 cites W136672989 @default.
• W1965839780 cites W1903887594 @default.
• W1965839780 cites W1957537518 @default.
• W1965839780 cites W1973965625 @default.
• W1965839780 cites W1983224547 @default.
• W1965839780 cites W1985170347 @default.
• W1965839780 cites W1991891818 @default.
• W1965839780 cites W1996548067 @default.
• W1965839780 cites W2002076761 @default.
• W1965839780 cites W2006382315 @default.
• W1965839780 cites W2007000374 @default.
• W1965839780 cites W2009975215 @default.
• W1965839780 cites W2018597546 @default.
• W1965839780 cites W2021949777 @default.
• W1965839780 cites W2049652135 @default.
• W1965839780 cites W2073345009 @default.
• W1965839780 cites W2079920409 @default.
• W1965839780 cites W2081259327 @default.
• W1965839780 cites W2084746077 @default.
• W1965839780 cites W2091228530 @default.
• W1965839780 cites W2094793402 @default.
• W1965839780 cites W2097593324 @default.
• W1965839780 cites W2112916314 @default.
• W1965839780 cites W2116344911 @default.
• W1965839780 cites W2151195343 @default.
• W1965839780 cites W2153853625 @default.
• W1965839780 cites W2158946057 @default.
• W1965839780 cites W2203165193 @default.
• W1965839780 cites W2258341156 @default.
• W1965839780 cites W2415225650 @default.
• W1965839780 cites W2464030180 @default.
• W1965839780 cites W342350979 @default.
• W1965839780 cites W4243006259 @default.
• W1965839780 doi "https://doi.org/10.1111/j.1349-7006.1994.tb02975.x" @default.
• W1965839780 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5919586" @default.
• W1965839780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7961126" @default.
• W1965839780 hasPublicationYear "1994" @default.
• W1965839780 type Work @default.
• W1965839780 sameAs 1965839780 @default.
• W1965839780 citedByCount "6" @default.
• W1965839780 crossrefType "journal-article" @default.
• W1965839780 hasAuthorship W1965839780A5013826509 @default.
• W1965839780 hasAuthorship W1965839780A5024085053 @default.
• W1965839780 hasAuthorship W1965839780A5028550766 @default.
• W1965839780 hasAuthorship W1965839780A5031781312 @default.
• W1965839780 hasAuthorship W1965839780A5035512198 @default.
• W1965839780 hasAuthorship W1965839780A5047706524 @default.
• W1965839780 hasAuthorship W1965839780A5055948716 @default.
• W1965839780 hasAuthorship W1965839780A5056018649 @default.
• W1965839780 hasAuthorship W1965839780A5057544635 @default.
• W1965839780 hasAuthorship W1965839780A5071371446 @default.
• W1965839780 hasAuthorship W1965839780A5081363686 @default.
• W1965839780 hasAuthorship W1965839780A5082139165 @default.
• W1965839780 hasBestOaLocation W19658397801 @default.
• W1965839780 hasConcept C153911025 @default.
• W1965839780 hasConcept C159654299 @default.
• W1965839780 hasConcept C163864487 @default.
• W1965839780 hasConcept C200155923 @default.
• W1965839780 hasConcept C202751555 @default.
• W1965839780 hasConcept C203014093 @default.
• W1965839780 hasConcept C2776364478 @default.
• W1965839780 hasConcept C2778690821 @default.
• W1965839780 hasConcept C502942594 @default.
• W1965839780 hasConcept C542903549 @default.
• W1965839780 hasConcept C55493867 @default.
• W1965839780 hasConcept C74172505 @default.
• W1965839780 hasConcept C86803240 @default.
• W1965839780 hasConceptScore W1965839780C153911025 @default.
• W1965839780 hasConceptScore W1965839780C159654299 @default.
• W1965839780 hasConceptScore W1965839780C163864487 @default.
• W1965839780 hasConceptScore W1965839780C200155923 @default.
• W1965839780 hasConceptScore W1965839780C202751555 @default.
• W1965839780 hasConceptScore W1965839780C203014093 @default.
• W1965839780 hasConceptScore W1965839780C2776364478 @default.
• W1965839780 hasConceptScore W1965839780C2778690821 @default.
• W1965839780 hasConceptScore W1965839780C502942594 @default.
• W1965839780 hasConceptScore W1965839780C542903549 @default.
• W1965839780 hasConceptScore W1965839780C55493867 @default.
• W1965839780 hasConceptScore W1965839780C74172505 @default.
• W1965839780 hasConceptScore W1965839780C86803240 @default.

• next