Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965842905> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W1965842905 endingPage "S207" @default.
- W1965842905 startingPage "S207" @default.
- W1965842905 abstract "Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant disease with a very poor prognosis. To date patient outcomes have not improved principally due to the limited number of patients suitable for surgical resections and the radiation and chemotherapy resistance of these tumours. In the last decade, a failure of conventional therapies has forced researchers to re-examine the environment of PDAC. The tumour environment has been demonstrated to consist of an abundance of stroma containing many cells but predominantly pancreatic stellate cells (PSCs). Recent research has focused on understanding the interaction between PSCs and PDAC cells in vitro and in vivo. It is believed that the interaction between these cells is responsible for supporting tumour growth, invasion and metastasis and creating the barrier to delivery of chemotherapeutics. Novel approaches which focus on the interactions between PDAC and PSCs which sustain the tumour microenvironment may achieve significant patient benefits. This manuscript reviews the current evidence regarding PSCs, their interaction with PDAC cells and the potential implication this may have for future therapies.A PubMed search was carried out for the terms ‘pancreas cancer’ OR ‘pancreatic cancer’, AND ‘pancreatic stellate cells’, NOT ‘hepatic stellate cells’. All studies were screened and assessed for their eligibility and manuscripts exploring the relationship between PSCs and PDAC were included. The studies were subdivided into in vitro and in vivo groups.One hundred and sixty-six manuscripts were identified and reduced to seventy-three in vitro and in vivo studies for review. The manuscripts showed that PDAC cells and PSCs interact with each other to enhance proliferation, reduce apoptosis and increase migration and invasion of cancer cells. The pathways through which they facilitate these actions provide potential targets for future novel therapies.There is accumulating evidence supporting the multiple roles of PSCs in establishing the tumour microenvironment and supporting the survival of PDAC. To further validate these findings there is a need for greater use of physiologically relevant models of pancreatic cancer in vitro such as three dimensional co-cultures and the use of orthotopic and genetically engineered murine (GEM) models in vivo." @default.
- W1965842905 created "2016-06-24" @default.
- W1965842905 creator A5055766682 @default.
- W1965842905 date "2011-09-01" @default.
- W1965842905 modified "2023-09-26" @default.
- W1965842905 title "S.14.01 Neuronal dysfunction and degeneration following brain insults: the role of the blood–brain barrier and blood–brain (dis)communication" @default.
- W1965842905 doi "https://doi.org/10.1016/s0924-977x(11)70293-0" @default.
- W1965842905 hasPublicationYear "2011" @default.
- W1965842905 type Work @default.
- W1965842905 sameAs 1965842905 @default.
- W1965842905 citedByCount "0" @default.
- W1965842905 crossrefType "journal-article" @default.
- W1965842905 hasAuthorship W1965842905A5055766682 @default.
- W1965842905 hasConcept C121608353 @default.
- W1965842905 hasConcept C126322002 @default.
- W1965842905 hasConcept C142724271 @default.
- W1965842905 hasConcept C150903083 @default.
- W1965842905 hasConcept C176891718 @default.
- W1965842905 hasConcept C202751555 @default.
- W1965842905 hasConcept C204232928 @default.
- W1965842905 hasConcept C207001950 @default.
- W1965842905 hasConcept C2778402981 @default.
- W1965842905 hasConcept C2778764654 @default.
- W1965842905 hasConcept C2779013556 @default.
- W1965842905 hasConcept C2780210213 @default.
- W1965842905 hasConcept C502942594 @default.
- W1965842905 hasConcept C52124034 @default.
- W1965842905 hasConcept C529278444 @default.
- W1965842905 hasConcept C55493867 @default.
- W1965842905 hasConcept C71924100 @default.
- W1965842905 hasConcept C86803240 @default.
- W1965842905 hasConcept C96232424 @default.
- W1965842905 hasConceptScore W1965842905C121608353 @default.
- W1965842905 hasConceptScore W1965842905C126322002 @default.
- W1965842905 hasConceptScore W1965842905C142724271 @default.
- W1965842905 hasConceptScore W1965842905C150903083 @default.
- W1965842905 hasConceptScore W1965842905C176891718 @default.
- W1965842905 hasConceptScore W1965842905C202751555 @default.
- W1965842905 hasConceptScore W1965842905C204232928 @default.
- W1965842905 hasConceptScore W1965842905C207001950 @default.
- W1965842905 hasConceptScore W1965842905C2778402981 @default.
- W1965842905 hasConceptScore W1965842905C2778764654 @default.
- W1965842905 hasConceptScore W1965842905C2779013556 @default.
- W1965842905 hasConceptScore W1965842905C2780210213 @default.
- W1965842905 hasConceptScore W1965842905C502942594 @default.
- W1965842905 hasConceptScore W1965842905C52124034 @default.
- W1965842905 hasConceptScore W1965842905C529278444 @default.
- W1965842905 hasConceptScore W1965842905C55493867 @default.
- W1965842905 hasConceptScore W1965842905C71924100 @default.
- W1965842905 hasConceptScore W1965842905C86803240 @default.
- W1965842905 hasConceptScore W1965842905C96232424 @default.
- W1965842905 hasLocation W19658429051 @default.
- W1965842905 hasOpenAccess W1965842905 @default.
- W1965842905 hasPrimaryLocation W19658429051 @default.
- W1965842905 hasRelatedWork W2050601193 @default.
- W1965842905 hasRelatedWork W2056761337 @default.
- W1965842905 hasRelatedWork W2084177191 @default.
- W1965842905 hasRelatedWork W2220916195 @default.
- W1965842905 hasRelatedWork W2582912872 @default.
- W1965842905 hasRelatedWork W2600123923 @default.
- W1965842905 hasRelatedWork W2796269683 @default.
- W1965842905 hasRelatedWork W2995878851 @default.
- W1965842905 hasRelatedWork W2999717614 @default.
- W1965842905 hasRelatedWork W4304116770 @default.
- W1965842905 hasVolume "21" @default.
- W1965842905 isParatext "false" @default.
- W1965842905 isRetracted "false" @default.
- W1965842905 magId "1965842905" @default.
- W1965842905 workType "article" @default.