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- W1965886931 abstract "Plasma growth hormone responses to insulin-induced hypoglycemia, orally administered glucose, and the intravenous infusion of arginine were normal in 4 children with growth retardation secondary to prolonged treatment with glucocorticoids. The short-term administration of growth hormone to 3 of these subjects resulted in nitrogen retention comparable to that observed in a patient with hypopituitarism who was treated similarly. Transient acceleration of linear growth rate was observed when somatotropin was administered to each patient for 6 months. Two of the four patients developed serum gamma globulins capable of binding growth hormone. It has been concluded that glucocorticoids do not suppress growth by inhibition of growth hormone release, but rather by peripheral antagonism to the long-term growth-promoting activities of somatotropin. Plasma growth hormone responses to insulin-induced hypoglycemia, orally administered glucose, and the intravenous infusion of arginine were normal in 4 children with growth retardation secondary to prolonged treatment with glucocorticoids. The short-term administration of growth hormone to 3 of these subjects resulted in nitrogen retention comparable to that observed in a patient with hypopituitarism who was treated similarly. Transient acceleration of linear growth rate was observed when somatotropin was administered to each patient for 6 months. Two of the four patients developed serum gamma globulins capable of binding growth hormone. It has been concluded that glucocorticoids do not suppress growth by inhibition of growth hormone release, but rather by peripheral antagonism to the long-term growth-promoting activities of somatotropin." @default.
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- W1965886931 date "1969-11-01" @default.
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- W1965886931 title "Studies of the secretion and metabolic effects of human growth hormone in children with glucocorticoid-induced growth retardation" @default.
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- W1965886931 doi "https://doi.org/10.1016/s0022-3476(69)80306-9" @default.
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