FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965893642> ?p ?o ?g. }

• W1965893642 endingPage "215" @default.
• W1965893642 startingPage "204" @default.
• W1965893642 abstract "Following the widespread use of immunosuppressive therapy and broad-spectrum antimycotic prophylaxis, C. glabrata has emerged as an important opportunistic pathogen in the oral mucosa. In the past, studies on the virulence factors and host-pathogen interactions of this organism were scarce, but continued to rise in recent years. Denture-wearing, immunosuppression, antibiotic therapy, and aging are risk factors for oral colonization or infection with C. glabrata. Compared with C. albicans, C. glabrata exhibits lower oral keratinocyte-adherence capacity, but higher denture-surface-adherence ability. The role of extracellular hydrolase production in the virulence of this organism does not appear to be as important as it is in C. albicans pathogenesis. Although traditionally thought of as a non-transforming yeast organism, both phenotypic switching and pseudohyphal formation have recently been identified in C. glabrata, but their role in pathogenesis is not known. With the exception of granulocyte monocyte colony-stimulating factor, C. glabrata triggers a lower proinflammatory cytokine response in oral epithelial cells than does C. albicans, in a strain-dependent manner. C. glabrata is less susceptible to killing by human beta-defensins than is C. albicans and exhibits various degrees of resistance to the antifungal activity of salivary histatins and mucins. In addition, C. glabrata possesses both innate and acquired resistance against antifungal drugs, due to its ability to modify ergosterol biosynthesis, mitochondrial function, or antifungal efflux. This resistance allows for its relative overgrowth over other susceptible species and may contribute to the recent emergence of C. glabrata infections in chronically immunocompromised populations. Further investigations on the virulence and host-pathogen interactions of C. glabrata are needed to better define the pathogenesis of oral C. glabrata infection in susceptible hosts." @default.
• W1965893642 created "2016-06-24" @default.
• W1965893642 creator A5003760816 @default.
• W1965893642 creator A5017105081 @default.
• W1965893642 creator A5091563483 @default.
• W1965893642 date "2007-03-01" @default.
• W1965893642 modified "2023-10-03" @default.
• W1965893642 title "<i>Candida glabrata</i>, an Emerging Oral Opportunistic Pathogen" @default.
• W1965893642 cites W123870293 @default.
• W1965893642 cites W1526536557 @default.
• W1965893642 cites W1558738137 @default.
• W1965893642 cites W1564109607 @default.
• W1965893642 cites W1571292455 @default.
• W1965893642 cites W1828773039 @default.
• W1965893642 cites W1885868886 @default.
• W1965893642 cites W1917218555 @default.
• W1965893642 cites W1921481560 @default.
• W1965893642 cites W1929090722 @default.
• W1965893642 cites W1937941011 @default.
• W1965893642 cites W1946868005 @default.
• W1965893642 cites W1950399079 @default.
• W1965893642 cites W1954009522 @default.
• W1965893642 cites W1959598455 @default.
• W1965893642 cites W1965315429 @default.
• W1965893642 cites W1976926996 @default.
• W1965893642 cites W1977118952 @default.
• W1965893642 cites W1979923902 @default.
• W1965893642 cites W1991458846 @default.
• W1965893642 cites W1996313477 @default.
• W1965893642 cites W1996364851 @default.
• W1965893642 cites W1997373267 @default.
• W1965893642 cites W2005360569 @default.
• W1965893642 cites W2007253594 @default.
• W1965893642 cites W2007947957 @default.
• W1965893642 cites W2010311163 @default.
• W1965893642 cites W2010805110 @default.
• W1965893642 cites W2010999630 @default.
• W1965893642 cites W2011504031 @default.
• W1965893642 cites W2011934816 @default.
• W1965893642 cites W2014225832 @default.
• W1965893642 cites W2014718976 @default.
• W1965893642 cites W2015187221 @default.
• W1965893642 cites W2015859713 @default.
• W1965893642 cites W2016145541 @default.
• W1965893642 cites W2017817339 @default.
• W1965893642 cites W2020137152 @default.
• W1965893642 cites W2021602471 @default.
• W1965893642 cites W2022006512 @default.
• W1965893642 cites W20233804 @default.
• W1965893642 cites W2026321324 @default.
• W1965893642 cites W2026449993 @default.
• W1965893642 cites W2029193776 @default.
• W1965893642 cites W2029994458 @default.
• W1965893642 cites W2033796008 @default.
• W1965893642 cites W2033893274 @default.
• W1965893642 cites W2036466813 @default.
• W1965893642 cites W2046034819 @default.
• W1965893642 cites W2050282039 @default.
• W1965893642 cites W2051586681 @default.
• W1965893642 cites W2052907432 @default.
• W1965893642 cites W2056595547 @default.
• W1965893642 cites W2059692941 @default.
• W1965893642 cites W2060211062 @default.
• W1965893642 cites W2062753943 @default.
• W1965893642 cites W2063475229 @default.
• W1965893642 cites W2064487923 @default.
• W1965893642 cites W2073414803 @default.
• W1965893642 cites W2073792588 @default.
• W1965893642 cites W2075016274 @default.
• W1965893642 cites W2076465259 @default.
• W1965893642 cites W2076738378 @default.
• W1965893642 cites W2081850449 @default.
• W1965893642 cites W2086487601 @default.
• W1965893642 cites W2090042814 @default.
• W1965893642 cites W2091350415 @default.
• W1965893642 cites W2091874747 @default.
• W1965893642 cites W2092448979 @default.
• W1965893642 cites W2095271467 @default.
• W1965893642 cites W2095696028 @default.
• W1965893642 cites W2095854759 @default.
• W1965893642 cites W2098144361 @default.
• W1965893642 cites W2101788869 @default.
• W1965893642 cites W2105204528 @default.
• W1965893642 cites W2106204280 @default.
• W1965893642 cites W2107669345 @default.
• W1965893642 cites W2108792803 @default.
• W1965893642 cites W2111023354 @default.
• W1965893642 cites W2112410790 @default.
• W1965893642 cites W2113068951 @default.
• W1965893642 cites W2113634763 @default.
• W1965893642 cites W2114886872 @default.
• W1965893642 cites W2116848973 @default.
• W1965893642 cites W2117778326 @default.
• W1965893642 cites W2118113765 @default.
• W1965893642 cites W2118488893 @default.
• W1965893642 cites W2118565151 @default.
• W1965893642 cites W2119407979 @default.
• W1965893642 cites W2121025359 @default.

• next