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• W1965895060 abstract "Summary Mycobacterium tuberculosis lipid antigens produce significant T cell responses in healthy tuberculin reactor [purified protein derivative (PPD-positive] individuals. In the present study, proliferation and interferon (IFN)-γ/interleukin (IL)-4 responses were analysed to M. tuberculosis total lipid antigens in T lymphocytes from 25 patients with multi-drug-resistant tuberculosis (MDR-TB). The obtained results were compared with those of 30 asymptomatic healthy PPD-positive and 30 healthy tuberculin skin test negative (PPD-negative) subjects. Peripheral blood mononuclear cells (PBMCs) and T cells (CD4+ and CD8+) were stimulated using autologous immature dendritic cells. Proliferation responses were assessed using 3–{4,5-dimethylthiazol-2-yl}–2,5 diphenyl tetrazolium bromide (MTT). IFN-γ/IL-4 concentrations in the supernatant of the CD4+ and CD8+T cells were measured by enzyme-linked immunosorbent assay. Proliferation assay showed that the peripheral blood mononuclear cells and CD4+ T cells from the MDR-TB patients responded significantly less to the M. tuberculosis total lipid antigens than to the CD4+ T cells in the PPD-positive subjects. Total lipid antigen-specific proliferative responses in the CD8+ T cells from the MDR-TB patients were minimally detected and the responses were similar to those of the PPD-positive subjects. IFN-γ production by the CD4+ T cells stimulated by total lipid antigens from the MDR-TB patients was decreased significantly compared with the PPD-positive individuals, whereas IL-4 production in the patients was elevated. IFN-γ and IL-4 production in the CD8+ T cells of the MDR-TB patients was similar to those of the PPD-positive subjects. In conclusion, it is suggested that stimulated CD4+ T cells by M. tuberculosis total lipid antigens may be shifted to T helper 2 responses in MDR-TB patients." @default.
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• W1965895060 date "2007-05-09" @default.
• W1965895060 modified "2023-10-15" @default.
• W1965895060 title "Evaluation of T cell immune responses in multi-drug-resistant tuberculosis (MDR-TB) patients to<i>Mycobacterium tuberculosis</i>total lipid antigens" @default.
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• W1965895060 doi "https://doi.org/10.1111/j.1365-2249.2007.03406.x" @default.
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