FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965895754> ?p ?o ?g. }

• W1965895754 endingPage "11375" @default.
• W1965895754 startingPage "11370" @default.
• W1965895754 abstract "We have molecularly characterized a proteolytic cleavage in conserved nuclear pore complex proteins. This cleavage, previously demonstrated to be essential for the biogenesis of two nuclear pore complex proteins in mammals (Nup98 and Nup96) and yeast (Nup145-N and Nup145-C), occurs between Phe and Ser residues within a highly conserved domain in a polyprotein precursor. Here, we show that a protease is not involved in the cleavage event. By using a combination of domain mapping and site-directed mutagenesis, we demonstrate that the human nuclear pore complex protein Nup98 specifically cleaves itself between F863 and S864. A region of Nup98, amino acids 715-920, is able to cleave, whereas a smaller region, amino acids 772-920, does not cleave. In addition, we have generated a Nup98 mutant that cleaves under defined conditions in vitro. Further, the two cleaved fragments of Nup98 form a complex, providing a possible mechanism whereby specific, yet low-affinity, binding between Nup98 and Nup96 is responsible for the nuclear targeting of Nup96. Although apparently unrelated evolutionarily, Nup98 has converged on an autoproteolytic biogenesis mechanism similar to that of hedgehog proteins, the inteins, and the N-terminal nucleophile proteins." @default.
• W1965895754 created "2016-06-24" @default.
• W1965895754 creator A5004261586 @default.
• W1965895754 creator A5081060821 @default.
• W1965895754 date "1999-09-28" @default.
• W1965895754 modified "2023-10-14" @default.
• W1965895754 title "Autoproteolysis in nucleoporin biogenesis" @default.
• W1965895754 cites W125778625 @default.
• W1965895754 cites W175731810 @default.
• W1965895754 cites W1821169949 @default.
• W1965895754 cites W1964361564 @default.
• W1965895754 cites W1967225591 @default.
• W1965895754 cites W1968863167 @default.
• W1965895754 cites W1968872346 @default.
• W1965895754 cites W1969542242 @default.
• W1965895754 cites W1976329458 @default.
• W1965895754 cites W1979074409 @default.
• W1965895754 cites W1980365141 @default.
• W1965895754 cites W1987945169 @default.
• W1965895754 cites W1990210405 @default.
• W1965895754 cites W1995260859 @default.
• W1965895754 cites W2008996638 @default.
• W1965895754 cites W2010119305 @default.
• W1965895754 cites W2014588097 @default.
• W1965895754 cites W2015851068 @default.
• W1965895754 cites W2016865656 @default.
• W1965895754 cites W2026550373 @default.
• W1965895754 cites W2031196013 @default.
• W1965895754 cites W2032951133 @default.
• W1965895754 cites W2033330638 @default.
• W1965895754 cites W2048052722 @default.
• W1965895754 cites W2052595740 @default.
• W1965895754 cites W2054177883 @default.
• W1965895754 cites W2057530446 @default.
• W1965895754 cites W2062049077 @default.
• W1965895754 cites W2065055005 @default.
• W1965895754 cites W2066498161 @default.
• W1965895754 cites W2075715889 @default.
• W1965895754 cites W2077080679 @default.
• W1965895754 cites W2080804130 @default.
• W1965895754 cites W2091748192 @default.
• W1965895754 cites W2095744767 @default.
• W1965895754 cites W2098551607 @default.
• W1965895754 cites W2100747051 @default.
• W1965895754 cites W2151298994 @default.
• W1965895754 cites W2182376660 @default.
• W1965895754 cites W266214044 @default.
• W1965895754 cites W35780613 @default.
• W1965895754 cites W4213262935 @default.
• W1965895754 cites W4247068375 @default.
• W1965895754 cites W68474887 @default.
• W1965895754 doi "https://doi.org/10.1073/pnas.96.20.11370" @default.
• W1965895754 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/18040" @default.
• W1965895754 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10500183" @default.
• W1965895754 hasPublicationYear "1999" @default.
• W1965895754 type Work @default.
• W1965895754 sameAs 1965895754 @default.
• W1965895754 citedByCount "108" @default.
• W1965895754 countsByYear W19658957542012 @default.
• W1965895754 countsByYear W19658957542013 @default.
• W1965895754 countsByYear W19658957542014 @default.
• W1965895754 countsByYear W19658957542015 @default.
• W1965895754 countsByYear W19658957542016 @default.
• W1965895754 countsByYear W19658957542017 @default.
• W1965895754 countsByYear W19658957542018 @default.
• W1965895754 countsByYear W19658957542019 @default.
• W1965895754 countsByYear W19658957542020 @default.
• W1965895754 countsByYear W19658957542021 @default.
• W1965895754 countsByYear W19658957542022 @default.
• W1965895754 countsByYear W19658957542023 @default.
• W1965895754 crossrefType "journal-article" @default.
• W1965895754 hasAuthorship W1965895754A5004261586 @default.
• W1965895754 hasAuthorship W1965895754A5081060821 @default.
• W1965895754 hasBestOaLocation W19658957541 @default.
• W1965895754 hasConcept C104317684 @default.
• W1965895754 hasConcept C126725582 @default.
• W1965895754 hasConcept C131934819 @default.
• W1965895754 hasConcept C143065580 @default.
• W1965895754 hasConcept C151730666 @default.
• W1965895754 hasConcept C16318435 @default.
• W1965895754 hasConcept C167625842 @default.
• W1965895754 hasConcept C175156509 @default.
• W1965895754 hasConcept C185592680 @default.
• W1965895754 hasConcept C190062978 @default.
• W1965895754 hasConcept C2780114586 @default.
• W1965895754 hasConcept C43369102 @default.
• W1965895754 hasConcept C515207424 @default.
• W1965895754 hasConcept C54757728 @default.
• W1965895754 hasConcept C55493867 @default.
• W1965895754 hasConcept C59157529 @default.
• W1965895754 hasConcept C68556195 @default.
• W1965895754 hasConcept C86803240 @default.
• W1965895754 hasConcept C95444343 @default.
• W1965895754 hasConceptScore W1965895754C104317684 @default.
• W1965895754 hasConceptScore W1965895754C126725582 @default.
• W1965895754 hasConceptScore W1965895754C131934819 @default.
• W1965895754 hasConceptScore W1965895754C143065580 @default.
• W1965895754 hasConceptScore W1965895754C151730666 @default.

• next